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Biomedical subjects

Hal Smith

Publications and source records attributed to Hal Smith.

8 recordsLinked to original sources

A resource-based model of microbial quiescence.

To analyze the ecological features of microbial quiescence, a model is proposed that involves "wake-up" rate and "sleep" rate at which the population transitions from a quiescent to an active state and back, respectively. These rates depend continuously on the resources and turn on and off at resource thresholds which may not coincide. The usual dichotomy is observed: the population is washed out under environmental stress and a single "survival" steady state exists otherwise. Proportional nutrient enrichment is used to explore analytically as well as numerically the nature of the steady state which bifurcates from the washout state.

Adaptation, Physiological↗

Biofilms and the plasmid maintenance question.

Can a conjugative plasmid encoding enhanced biofilm forming abilities for its bacterial host facilitate the persistence of the plasmid in a bacterial population despite conferring diminished growth rate and segregative plasmid loss on its bearers? We construct a mathematical model in a chemostat and in a plug flow environment to answer this question. Explicit conditions for an affirmative answer are derived. Numerical simulations support the conclusion.

Bacterial Physiological Phenomena↗

Transfers to civil psychiatric inpatient services from a maximum security forensic hospital.

OBJECTIVE: To examine inpatients discharged from a forensic psychiatric hospital to a civil hospital at the completion of their correctional sentence. METHOD: Extract information from a patient database. RESULTS: About 20% of the discharges from the New York State forensic hospital that serves mentally ill state prison inmates, Central New York Psychiatric Center (CNYPC), are transferred to a civil psychiatric hospital; the remainder are returned to a correctional setting. Although their diagnoses, Global Assessment of Functioning scores, and number of prior inpatient admissions are similar, CNYPC transfers stay 1(1/2) times as long in their civil hospital admission as other civil hospital admissions. If total inpatient hospitalization before release to the community at large is considered (CNYPC plus the subsequent civil hospital), the stay is about 2(1/2) times as long. Fifty-two percent of the CNYPC transfers had been incarcerated for violent offenses and 28% are re-hospitalized within 12 months after release from the civil hospital. DISCUSSION: Longer lengths of stay in the civil hospital for these CNYPC transfers do not seem to be related to psychiatric functioning. Instead, it may be related to being harder to place in a community setting. All these CNYPC transfers have prison histories, many have a violent offense history, and all have been geographically remote from their home communities for a long time periods. As a result, the social support networks of CNYPC transfers may be weaker than those of other civil inpatients. The families and neighborhood agencies of CNYPC transfers are probably less willing to accept them on their return than those of other civil patients.Enhanced discharge planning and support services targeted specially for correctional transfers to a civil psychiatric inpatient environment should be considered. These type of service may reduce inpatient length of stay and thereby allow the inpatient resources to be used by other patients.

Forensic Psychiatry↗

Correctional mental health services in New York: then and now.

This article chronicles the legislation, litigation, and the agency initiatives which have shaped the New York State correctional mental health system into what it is today. An historical perspective provides a context and framework for the examination of the current and future salient issues and challenges in providing a comprehensive range of mental health services in a correctional setting. The Central New York Psychiatric Center organization, which is comprised of a 206 bed maximum-security forensic hospital and a community support network of 23 prison-based mental health units was established in 1977. This article takes an in-depth look at the organization's 25-year growth and development, the implementation and outcome of some innovative treatment programs, and the unique partnership between the New York State Office of Mental Health (OMH) and the New York State Department of Correctional Services (DOCS).

Forensic Psychiatry↗

The Freter model: a simple model of biofilm formation.

A simple, conceptual model of biofilm formation, due to R. Freter et al. (1983), is studied analytically and numerically in both CSTR and PFR. Two steady state regimes are identified, namely, the complete washout of the microbes from the reactor and the successful colonization of both the wall and bulk fluid. One of these is stable for any particular set of parameter values and sharp and explicit conditions are given for the stability of each. The effects of adding an anti-microbial agent to the CSTR are examined.

Algorithms↗

Feedback control for chemostat models.

It is shown that a chemostat with two organisms can be made coexistent by means of feedback control of the dilution rate. Remaining freedom in the feedback law can be used to guarantee robustness or improve particular performance indices. Unfortunately a topological property prevents coexistence by feedback control for chemostats with more than two organisms. We apply our results to control bioreactors aimed at producing commercial products through genetically altered organisms. In all our results the coexistence takes its simplest form: a global asymptotically stable equilibrium point in the interior of the non-negative orthant.

Bacteria↗

Central New York Psychiatric Center: an approach to the treatment of co-occurring disorders in the New York State correctional mental health system.

Central New York Psychiatric Center operates a maximum security inpatient treatment hospital and outpatient mental health services for all of the 72 New York State prisons. In this article prevalence data, patient characteristics, and interventions offered to inmates diagnosed with co-occurring mental illness and substance abuse disorders in the New York State prison system are reviewed and discussed. Available interventions have resulted from the close collaboration of the State Department of Correctional Services and State Office of Mental Health. Aspects of current programs and plans for future service developments are discussed along with implications for the treatment of an offender population diagnosed with a co-occurring disorder.

Adult↗

Personality disorders in prison: aren't they all antisocial?

The provision of mental health services in the correctional system is challenging at best for various clinical, administrative, and structural reasons. Among the complicating factors is the assessment and management of character pathology which either confounds the treatment of more "serious" mental illnesses, e.g. Axis I disorders, and/or presents itself as the primary focus for intervention. In this paper we review the prevalence of personality disorders on the prison mental health services caseload in New York State. We compare inpatient and out-patient rates among the various disorders documented in the prison system, as well as look at these rates within the context of the rates of personality disorder in the state mental health system generally. Assessment of personality disorder will be addressed with particular attention to the confounding influence of the prison environment. Finally, treatment options will be discussed, including discussion of new initiatives that attempt to address inmates with serious mental illness and personality traits that lead to disciplinary housing.

Adult↗