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Biomedical subjects

Hüseyin Seven

Publications and source records attributed to Hüseyin Seven.

4 recordsLinked to original sources
PubMed2004

Investigation of Helicobacter pylori colonization in laryngeal neoplasia.

Helicobacter pylori has been investigated in several other organ systems and localizations such as the oral cavity, but has not been investigated extensively in squamous cell carcinoma of the larynx, a region that could be directly exposed to the bacterium by the oral route or gastro-esophageal reflux. Only serological studies are available regarding the relation between H. pylori and laryngeal cancer, yielding conflicting results. To our knowledge, there is no study investigating the presence of H. pylori in laryngeal squamous cell carcinoma tissue. The purpose of this study was to investigate the presence of H. pylori in laryngeal squamous cell carcinoma tissue and to investigate the possible role of this organism in the etiopathogenesis of laryngeal cancer. Specimens from 50 patients with laryngeal cancer who underwent total or partial laryngectomy between March 1999 and December 2002 were examined by histopathological and immunohistochemical methods to detect H. pylori. The presence of H. pylori was also investigated histopathologically in 50 benign laryngeal biopsy specimens. In our study, we demonstrated that H. pylori was not present in laryngeal squamous cell carcinoma tissue or in the benign lesions. We could not find any evidence indicating that H. pylori played a role at the tissue level in the pathogenesis of laryngeal carcinoma.

Adult↗
PubMed2003

Pulmonary thromboembolism following total laryngectomy and neck dissection: a case report.

A fifty-five-year-old male patient underwent total laryngectomy, bilateral modified radical neck dissection, and primary voice restoration for squamous cell carcinoma of the supraglottic larynx. During surgery the left internal jugular vein was found to be thrombosed and, therefore, ligated and resected. In the early postoperative period, pulmonary thromboembolism was suspected and confirmed by lung perfusion scintigraphy which showed bilateral segmental and subsegmental perfusion defects. The patient was successfully treated by anticoagulant therapy. It may be advisable to consider thromboprophylaxis in head and neck surgery in patients with clinically suspected pulmonary thromboembolism, if no contraindication exists.

Anticoagulants↗
PubMed2003

[The topographical anatomy of the external branch of the superior laryngeal nerve and its importance in thyroid surgery: a cadaver study].

OBJECTIVES: We investigated topographical anatomic features of the external branch of the superior laryngeal nerve (SLN) in relation to the superior thyroid artery (STA) and its vulnerability to injury in individuals with a normal thyroid size. STUDY DESIGN: Thirty fresh cadavers (18 females, 12 males; age range 20 to 50 years) with a normal thyroid size and no signs of abnormality in the neck were studied. The external branch of the SLN was identified and classified according to the system proposed by Cernea et al. RESULTS: The topographical relationship between the external branch of the SLN, the STA, and the upper pole of the thyroid gland was identified in 54 thyroid lobes (90%). Identification was not possible in six lobes because of bleeding or injury. The location of the external branch of the SLN was consistent with type 1 in 28 lobes (51.8%) and type 2 in 26 lobes (48.2%; type 2a in 37.1% and type 2b in 11.1%). No significant relationships existed between the type of the nerve, gender, and age, nor was there any symmetry with regard to the location of the external branch of the SLN in the same subject. CONCLUSION: Nearly half of the Turkish population with a normal thyroid gland size present high surgical risks during thyroid surgery because of the course of the external branch of the SLN.

Adult↗