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Biomedical subjects

H Zimmermann

Publications and source records attributed to H Zimmermann.

At least 271 records · Page 15Linked to original sources
PubMed1980

[The course of treated chronic obstructive lung disease].

Retrospective analysis of the influence of therapy on the course of chronic obstructive lung disease in 71 patients over 3 years showed that cessation of smoking, long-term therapy with corticosteroids and IPPB-therapy did not significantly alter the functional deterioration. The average annual FEV decline of 68 ml ((initial FEV 1.28 +/- 0.661) is comparable with the results of other authors. The importance of controlled, prospective therapeutic trials is stressed.

Adrenal Cortex Hormones↗
PubMed1980

Mitochondrial release of Ca2+ during sustained nerve activity in the electric organ of Torpedo marmorata.

The calcium content of mitochondria isolated from the Torpedo electric organ was determined by atomic absorption spectroscopy. The mitochondrial fraction was found to contain 830 ng-atom Ca/mg protein. For comparison a fraction of isolated nerve endings contained 250 ng-atom Ca/mg protein. When tissue was continuously stimulated at a frequency of 5 Hz via the electromotor nerves, the Ca content of the mitochondrial fraction which is likely to contain both pre- and postsynaptic mitochondria was reduced proportionally to the decrease in transmitter content of the isolated nerve terminal fraction. After 5,000 pulses, the mitochondrial fraction had lost 80% of its Ca contents. When tissue was stimulated after previous perfusion with d-tubocurarine and blockade of electrical response the same number of pulses caused only a loss of 20--40% in the Ca content of the mitochondrial fraction. Release of transmitter was not affected by d-tubocurarine. The results suggest that repetitive stimulation in the absence of postsynaptic receptor blockade causes loss of Ca from both nerve terminal mitochondria and mitochondria of the myotube-derived electrocytes. In the presence of d-tubocurarine Ca is lost from presynaptic mitochondria only.

Acetylcholine↗
PubMed1980

Preferential calcium staining of mitochondria in stimulated cholinergic nerve endings.

The fine structure of the Torpedo electric organ was investigated during different functional states using fixation media with elevated calcium concentrations. When electric tissue was stimulated (5,000 pulses, 5 Hz) and subsequently fixed in an s-collidine buffered aldehyde fixative containing 5 mM CaCl2 mitochondria in both nerve terminals and postsynaptic electroplaque cells showed electron-dense deposits. When tissue blocks were stimulated in the presence of d-tubocurarine (250 microM) which blocked electrical response deposits were restricted to presynaptic mitochondria. Electron-dense deposits were never observed in unstimulated tissue. The observations suggest that after stimulation mitochondria have an increased calcium binding capacity. In conjunction with previous biochemical findings (Schmidt and Zimmermann, 1980), we suggest that this increased binding capacity is due to a previous stimulation induced loss of calcium from activated mitochondria.

Animals↗
PubMed1980

Posterior urethral duplication and triplication in the male.

This is a report of a case of urethral triplication in a male baby with two accessory urethral channels terminating at the perineum and a normally situated but partially strictured urethra. Classification of urethral duplications is discussed and an embryologic explanation of type III urethral duplications proposed.

Humans↗
PubMed1980

Pharmacological evidence that stimulation of central serotonergic pathways increases renin secretion.

To determine if serotonin plays a role in the regulation of renin secretion, pentobarbital-anesthetized dogs were injected intravenously with drugs which modify serotonin metabolism. Renal perfusion pressure was kept constant by a clamp on the aorta proximal to the renal arteries. 5-Hydroxytryptophan (5-HTP) caused a significant increase (p less than 0.05) in arterial plasma renin activity (pra) that was abolished when peripheral and central aromatic amino acid decarboxylase activities were inhibited by administration of benserazide, but not reduced when only the peripheral decarboxylase activities were inhibited by administration of carbidopa. The serotonin receptor blocking drug metergoline also abolished the renin response to 5-HTP. L-Tryptophan in two different doses increased PRA. This increase was not reduced by carbidopa but was reduced or abolished by benserazide, metergoline, and renal denervation. The increase in PRA produced by 5-HTP and L-Tryptophan occurred without any change in blood pressure. 5-HTP had no effect on heart rate but L-Tryptophan reduced heart rate. These data indicate that 5-HTP and L-Tryptophan act on the central nervous system to produce an increase in renin secretion that is mediated via the renal nerves and occurs without a concomitant increase in sympathetic output to the heart or blood vessels. The increase appears to be due to the release of serotonin within the central nervous system.

5-Hydroxytryptophan↗
PubMed1980

[Reproduction of Brucella titers in swine using experimental infection with Yersinia enterocolitica, serotypes 0:9 and 0:6].

Measurable Brucella titres were produced by slow agglutination, slow agglutination at 57 degrees C (heat test), and complement fixation reaction with Brucella antigen in infection experiments with gilts in which Yersinia enterocolitica Serotypes 0:9 and 0:6 were used. Slow agglutination gave brucellosis titres up to 1:1280 and titres against Yersinia enterocolitica, Serotype 0:9, up to 1:20480. The antibody titres stayed persistent throughout the 80 days of the experiment. Yersinia enterocolitica infection was found to be transmissible between the animals. Aspects relating to the development and course of the infection as well as to pathogen detection are discussed.

Animals↗
PubMed1980

[X-ray differential diagnosis of unilateral pulmonary emphysematous expansion in newborn and babies (author's transl)].

The article discusses the x-ray signs seen in 14 babies with unilateral emphysematous expansion. 7 of these infants had a lobar emphysema without any defect of the bronchial cartilage, whereas two had pulmonary cysts, one suffered from a congenital cystic adenomatoid pulmonary malformation, and one infant had been suffering from lymphangiectasy; in all cases, successful lobectomy had been performed. One patient with pneumatocele, one with a left-side agenesia of the upper lobe and one with a transient obstruction of the bronchi by a mucous plug, were given conservative treatment. The article discusses the x-ray differentiation of the following disturbances: pneumothorax, diaphragmatic hernia, compensatory and obstructive emphysematous expansion of a pulmonary lobe, cystic changes in the lung, and lobar emphysema, although this does not offer any possibility of discovering the reason for its occurrence. Attention is drawn to the diagnostic value of bronchoscopy and bronchography, as well as angiography, especially in case of suspected vascular malformation.

Cysts↗
PubMed1980

[Postoperative complications following the Gross-procedure for hypospadias (author's transl)].

One of the major aims of hypospadias correction to the urethral meatus should be at the tip of the glans. This can be achieved with the two-stage procedure described by Gross. However even this procedure has a high fistula-rate. A modification is therefore suggested originally described by Mathieus which we now utilise during the second-stage procedure. This modification appears to reduce the fistula rate.

Adolescent↗
PubMed1979

5'-triphosphate recycles independently of acetylcholine in cholinergic synaptic vesicles.

The effect of hemicholinium-3 (HC-3) on vesicular contents in acetylcholine (ACh) and 5-triphosphate (ATP) and the vesicular incorporation of 14C-label derived from [14C]choline ,nd 3H-label derived from [3H]adenosine was investigated after low frequency stimulation (with a subsequent rest period) of the Torpedo electric organ. HC-3 (100 microM) caused an increased depletion of vesicular ACh and blocked the incorporation of 14C-label whereas contents in vesicular ATP and 3H-incorporation were identical with and without HC-3. HC-3 also blocked the recovery of electrical response of the tissue after stimulation but did not cause a change in vesicle numbers. The result suggest that synaptic vesicles continue to recycle ATP in the absence of recycling of ACh and that vesicular uptake and storage of the two components are not coupled to each other.

Acetylcholine↗
PubMed1978

[Obesity and cardiovascular risk].

Epidemiological studies on the relationship of obesity, morbidity and mortality revealed the following results: In life insurance studies, excess mortality of obese people was found with more than 30 percent overweight. Mortality was caused by cardiovascular disease and diabetes mellitus. Obesity at issue of the policy in younger age was a greater risk than in the older age group. In prospective studies with long follow-up periods (greater than 16 years) it could be shown that obesity alone was a risk factor for coronary heart disease, the risk being greatest for men and middle aged women. However, the prevalence of accepted risk factors in an obese population is so high that the question whether obesity alone is a risk factor for coronary heart disease is of little interest. The correlations between obesity and risk factors were of minor magnitude; therefore other factors, such as age or HDL-cholesterol, should be considered in the elucidation of the relationship between obesity and coronary heart disease. HDL-cholesterol appears to be a powerful independent protective factor which is diminished in obesity. Despite the fact that studies proving a prolongation of life by treating obesity are not available, the treatment of obesity may be beneficial for the patient by diminishing risk factors.

Adult↗