Search PubMed⌕ Search

Biomedical subjects

H Zimmer

Publications and source records attributed to H Zimmer.

At least 37 records · Page 2Linked to original sources
PubMed1989

[Anticipatory and event related changes in heart rate as indicators of attention processes].

The present study was concerned with the question of whether phasic event-related heart rate (HR) changes under easy intake conditions account for the association between anticipatory HR deceleration and task performance in a choice reaction time (RT) task with a fixed foreperiod. The task employed differed from simple RT tasks especially with regard to processing and attention demands. Subjects were required to determine as quickly and accurately as possible whether a probe, presented for 80 ms, was identical or not to one of two distinct memory items, presented at the onset of each trial. Reaction times as well as accuracy of responses were determined. The results of the present study were indicative of a reliable anticipatory HR deceleration which was related to latency of responses to the probe stimulus. Subjects with stronger decelerations reacted faster than subjects with diminished or missing decelerations. Furthermore a relation was found between this association and the heart rate changes to repeated presentations of a non-signal auditory stimulus under habituation conditions. Results were discussed in terms of differences in the regulation or control of attentional processes.

Adult↗
PubMed1981

Immunologic effects of hydralazine in hypertensive patients.

Twenty-seven hypertensive patients (23 blacks, 4 whites) treated with hydralazine had frequent serologic evidence of autoimmunity. However, only 1 patient developed a lupus syndrome. Acetylator phenotype influenced the autoimmune response; slow acetylators had a higher incidence and titers of autoantibodies. The lupus patient not only had high titers of autoantibodies but they were predominantly IgG in contrast to the predominant IgM antibodies found in other slow acetylators. Hydralazine treatment did not alter cell-mediated immune responses and hydralazine antibodies were not detected. However, half the patients tested who received hydralazine had positive lymphoproliferative responses to the drug.

Acetylation↗
PubMed1981

Prospective study of immunologic effects of hydralazine in hypertensive patients.

Twenty-seven hypertensive patients (23 of whom were black) were treated with hydralazine as their major antihypertensive drug and were followed for evidence of autoimmunity and clinical systemic lupus erythematosus (SLE). Only one patient developed SLE but many, although asymptomatic, had serologic evidence of autoimmunity: antibodies to single- and double-stranded ribonucleic acid (RNA), single-stranded deoxyribonucleic acid (DNA), histones, and lymphocytes. Acetylation phenotype profoundly influenced this response; slow acetylators had a higher incidence and larger amounts of autoantibodies. Antibodies to both types of RNA were a more sensitive index of autoimmunity than antinuclear antibodies. Hydralazine treatment did not alter cell-mediated immune responses. The hydralazine SLE patient had large amounts of autoantibodies that were predominantly IgG, while in the others IgM autoantibodies were predominant. No antibodies, but positive lymphoproliferative responses to hydralazine, were found in half the patients tested.

Acetylation↗
PubMed1977

Acetylator phenotype in systemic lupus erythematosus.

The acetylation rate of sulfamethazine was studied in 25 patients with systemic lupus erythematosus (SLE). Seventeen of 25SLE patients, 68%, were slow acetylators compared to the reported incidence of 52% in the general population. There was no correlation between the acetylator phenotype in SLE patients and the various clinical manifestations or the activity of the disease. Lupus patients who were slow acetylators had a lower lymphocyte response to phytomitogens compared to rapid acetylators.

Acetylation↗
PubMed1977

[Radiological interpretation of bone regeneration after cystectomy of odontogenic cysts].

38 patients who had undergone surgical intervention (Partsch II) for odontogenic cysts were examined radiographically as well as clinically. The extent of bone regeneration was estimated according to age, sex, location of the cyst in the jaw, cyst size, length of time elapsed after operation and function. To facilitate the interpretation of the results obtained, the patients were subdivided into five age groups. Bone regeneration was most frequent up to the age of 20 (85.7%). It occurred more often in women (in 11 of 16 patients = 68.75%) than in men (in 14 of 22 patients = 63.6%). Bone healing was most favourable in the anterior region of the mandible less, favourable in the posterior region of the maxillae and least favourable in the anterior region of the upper jaw. With increasing size of the cyst, the regenerative power of the bone decreased. An increase in regeneration was observed up to 3 years after surgical intervention.

Adolescent↗
PubMed1975

3-Hydroxymethyl-s-triazolo[3,4-a]phthalazine, a novel urinary hydralazine metabolite in man.

The elucidation of the structure of a new major metabolic product of hydralazine, 3-hydroxymethyl-s-triazolo[3,4-a]-phthalazine, is described. The structures of several other previously described metabolites of the drug, phthalazone, s-triazolo[3,4-a]phthalazine, and 3-methyl-s-triazolo[3,4-a]phthalazine, are confirmed. A metabolic pathway of hydralazine is also proposed.

Humans↗
PubMed1975

Induction of antibodies to nuclear antigens in rabbits by immunization with hydralazine-human serum albumin conjugates.

The antihypertensive drug hydralazine can induce in man a syndrome similar to spontaneous systemic lupus erythematosus (SLE). The pathogenesis of this drug-induced syndrome is not understood. In this investigation, five groups of rabbits were studied: group I, 10 rabbits hyperimmunized with hydralazine conjugated to human serum albumin (HSA) in complete Freund's adjuvant (CFA); group II, four rabbits with HSA in CFA; group III, four rabbits with CFA alone; group IV, five rabbits with hydralazine conjugated to rabbit serum albumin (RSA); and group V, four rabbits with a major metabolite of hydralazine conjugated to HSA. The rabbits immunized with hydralazine-HSA developed rising titers of antibodies to hydralazine and progressively increasing amounts of antibodies to both single-stranded and native DNA. The antibodies to DNA were cross-reactive with hydralazine as determined by inhibition of DNA binding and DNA hemagglutination tests. Similar results were obtained in rabbits immunized with the metabolite-HSA compound except the major hapten antibody response was to the metabolite. The DNA antibodies in this group were also capable of being absorbed by metabolite-HSA as well as hydralazine-HSA, indicative of the cross-reactivity between hydralazine and its metabolite. Immunization with hydralazine-RSA caused rabbits to produce antibodies to hydralazine but not to DNA, indicating the requirement for an immune response to the carrier protein in order for antibodies reactive with DNA to be produced. Thus, hyperimmunization of rabbits with hydralazine-protein conjugates may provide a useful animal model of SLE. The data suggests that an immune response to hydralazine may be important in human hydralazine-induced SLE.

Animals↗
PubMed1975

Associated diagnoses which complicate rehabilitation of the patient with bilateral lower extremity amputations.

Cardiopulmonary problems were the most common limiting factor in the rehabilitation of 42 bilateral lower limb amputees. Diabetes mellitus and local stump problems, most common in below knee amputees, delayed rehabilitation but, subsequently, obtained the highest goals. Thirty of the 42 amputees finally were self sufficient; the average time required was 30 weeks to maximum benefit.

Adult↗
PubMed1975

Rehabilitation after bilateral lower extremity amputation.

Fourty-four men (average age, 61.5 years) who had undergone amputation of both lower extremities were studied at a Veterans Administration hospital. Vascular insufficiency was the most frequent reason for amputation. In 26 of the patients bilateral below-knee amputations had been performed. Although diabetes mellitus was present in 26 of the patients, it severely hampered rehabilitation in only four. Twenty-nine (nearly 65%) of the 44 patients became totally independent in daily functions. However, the average time required for maximum rehabilitation was almost 30 weeks.

Aged↗
PubMed1975

What influence does age have on rehabilitation of amputees?

A study of 194 male lower extremity amputees, with an average age of 56.8 years, showed that vascular disease is the most common cause of limb loss at all ages. Increasing age was correlated with an increasing incidence of bilateral amputation and arteriosclerotic and pulmonary problems, lower goals and levels of achievement, increased mortality during therapy, fewer amputees who were able to return home, an increased number of aids (cane, crutches, wheelchair), and a longer rehabilitation period. Many patients over age 65 required nearly a year of rehabilitation to achieve maximum benefit.

Adult↗