Biomedical subjects

H Ziegler

Publications and source records attributed to H Ziegler.

At least 127 records · Page 7Linked to original sources

PubMed1975

[Central action of WA-335-BS, a substance with peripheral antiserotonin and antihistaminic activity].

In rats and mice the serotonin and histamine antagonistic drug 9,10-dihydro-10-(1-methyl-4-piperidylidene)-9-anthrol (WA 335-BS) caused stronger central sedative effects than did cyproheptadine. WA 335-BS also displayed stronger activity against reserpine- and central tremorine-induced effects than did cyproheptadine and it slightly enhanced d-amphetamine-induced effects: therefore it may have antidepressant properties. WA 335-BS proved to be very effective against isolation-induced aggression in male mice. The comparatively small anxiolytic effects may have been caused in part by the central antiserotonin properties. Like cyproheptadine, WA 335-BS increased food consumption in cats. In EEG-experiments in the conscious rabbit the serotonin-antagonistic drugs WA 335-BS and cyproheptadine exerted stronger depressant activity on the arousal reactions than did the neuroleptic chlorpromazine. The results of our animal studies suggest WA 335-BS to be an antidepressant with sedative properties.

Aggression↗

PubMed1975

[Xenon exhalation measurements in the diagnosis of bladder diseases].

Using an exhalameter radioactive marked Xenon, absorbed following bladder instillation, was determined in the expired air of 111 patients. In 65 of these patients the usual criteria in the diagnosis of bladder diseases were simultaneously ascertained. The functional disturbances of the epithelium of the bladder obtained through 133Xenon exhalation measurements did not correlate with the morphological changes. Especially in the so-called "Reizblase" (irritable bladder) functional disturbances were found without a morphological equivalent. Compared with the low Xenon exhalation found in patients with healthy urinary bladders there is a marked Xenon exhalation increase (10-15 times) in inflammation of the urinary bladder. In our opinion Xenon exhalation measurements is at the present time the most sensitive method for determining inflammatory diseases of the urinary bladder.

Air↗

PubMed1975

[A new model for reflux prevention following distal and total stomach resection].

By means of a short isoperistaltic invagination of a small bowel segment a valve mechanism has been developed experimentally. After complete or partial gastric resection (B II) reflux of alkaline intestinal secretion could be prevented. Even under extreme pathological conditions like head down position and external compression normal valve function has been achieved.

Animals↗

PubMed1975