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Biomedical subjects

H Zeidler

Publications and source records attributed to H Zeidler.

At least 145 records · Page 8Linked to original sources
PubMed1994

Complicated Cogan's syndrome with aortic insufficiency and coronary stenosis.

We describe a case of Cogan's syndrome in a 19-year-old woman with tinnitus, deafness, interstitial keratitis, and complicating aortic insufficiency and coronary stenosis. Serological testing revealed IgG and IgA antibodies against Chlamydia trachomatis. In spite of very high antibody titers there was no direct evidence for C. trachomatis in her urogenital smears or in biopsies of her aortic adventitia, and therefore these findings are of uncertain significance. Reconstruction of the aortic valve and bypass surgery for an ostial stenosis of the left coronary artery were necessary. Ten months after starting cyclosporine treatment her course was stable and cochlear implant surgery was successfully performed.

Adult↗
PubMed1993

Drug-related lupus in a patient with rheumatoid arthritis under sulfasalazine treatment.

The induction of lupus-like syndromes with the appearance of single-stranded DNA antibodies is a well-known complication of drug therapy. In this report we present a patient with an erosive seropositive rheumatoid arthritis developing the clinical and serological features of systemic lupus erythematosus including the occurrence of double-stranded DNA antibodies under sulfasalazine treatment.

Adult↗
PubMed1993

Intracellular persistence of chlamydial major outer-membrane protein, lipopolysaccharide and ribosomal RNA after non-productive infection of human monocytes with Chlamydia trachomatis serovar K.

The replication of Chlamydia trachomatis serovar K was studied in human peripheral blood monocytes (PBMo). The intracellular fate of the bacteria was examined by determining the presence of chlamydial major outer-membrane protein (MOMP), lipopolysaccharide (LPS) and ribosomal RNA (rRNA). In-vitro infection of PBMo with C. trachomatis serovar K was not productive. However, chlamydial MOMP antigen, demonstrated by immunofluorescence, was present in PBMo for up to 14 days. Infected monocytes also contained chlamydial rRNA, measured by in-vitro hybridisation, and LPS, measured by enzyme immunoassay, for up to 14 days. These data are compatible with the hypothesis that the infection of PBMo with C. trachomatis may play a role in the systemic distribution of chlamydial antigens, leading to systemic manifestations of urogenital chlamydial infection.

Bacterial Outer Membrane Proteins↗
PubMed1993

Follow-up of patients with double stranded DNA antibodies induced by sulfasalazine during the treatment of inflammatory rheumatic diseases.

Twenty-four patients with chronic inflammatory joint diseases developed double stranded DNA (dsDNA) antibodies during sulfasalazine (SAS) therapy and 20 of these 24 patients could be followed over a mean period of 11 months. Only one of the patients showed clinical symptoms of systemic lupus erythematosus (SLE). DsDNA antibodies were transient in two thirds of the patients discontinuing SAS treatment and in the same proportion of the individuals who did not interrupt this medication.

Adult↗
PubMed1992

Epidemiology and economics of NSAID-induced gastropathy.

Nonsteroidal anti-inflammatory drug (NSAID) use and gastrointestinal (GI) injury and symptoms are associated in clinical practice, but the importance of this injury is debatable. Most rheumatologists and general practitioners view NSAIDs as extremely valuable and generally well-tolerated first-line agents in the treatment of arthritis and musculoskeletal disorders. Generally, gastroenterologists and surgeons, on the other hand, insist that NSAIDs are dangerous and potentially lethal irritants to the GI mucosa. More frequent NSAID-induced gastropathy may be related to general epidemiological trends in NSAID-using populations: longer life expectancy, multiple risk co-factors for peptic ulcer disease (ie, smoking, alcohol, diet, comedication), and the increased availability of endoscopic examinations. Based on endoscopic studies, the prevalence of NSAID-induced adverse GI events has been documented in published reports. The frequency of bleeding is related to dose and duration of NSAID therapy. Overall, the prevalence of ulcer complications is higher in patients who consume NSAIDs. Cost-benefit analyses indicate that preventing potential GI damage with agents such as misoprostol may reduce the expense of treating the GI side effects associated with NSAID therapy.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1992

Undifferentiated spondyloarthropathies.

The term undifferentiated spondyloarthropathy (uSpA) refers to patients with clinical and roentgenographic features suggestive of spondyloarthropathies but not fulfilling the diagnostic or classification criteria for any of the currently established disease categories. The frequency and clinical spectrum of uSpA have been ignored in previous epidemiologic and clinical studies. A generally accepted nosologic concept and definition of uSpA may be needed to overcome this issue. So far the recently developed ESSG criteria have the broadest basis of consent, at least for several European centers. With the use of the ESSG classification criteria the real prevalence may be better defined in the future and the early classification of such patients in clinical practice should be advanced. Nevertheless, the diagnosis of uSpA is only a working label with the implicit demand to solve the clinical conundra by follow-up or even better by identifying the causative or triggering infectious agents.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1991

[Systemic lupus erythematosus (SLE) with panniculitis and rhabdomyolysis].

In systemic lupus erythematosus as a multi-system disease the involvement of skeletal muscle has been described as a rather mild polymyositis, myopathy or inclusion-body myositis. Here we present a patient with a severe lupus presenting with a fulminant myositis with rhabdomyolysis and panniculitis.

Adult↗
PubMed1991

Epidemiology and NSAID induced gastropathy.

Population based epidemiologic studies of gastropathy associated with the use of non-steroidal antiinflammatory drugs (NSAID) have shown that NSAID users are at increased risk of adverse gastrointestinal (GI) events and ulcer complications, that the risk of NSAID induced gastropathy is increased among older persons, and that such factors as alcohol use, anticoagulant use and prior GI disorders contribute to the risk of adverse GI events. Clinical epidemiologic studies have shown that ulcer and other mucosal damage is present in a large proportion of NSAID users and that such damage is largely asymptomatic. Overall, evidence indicates that NSAID induced gastropathy is responsible for a significant proportion of serious ulcer complications and associated mortality. More data are needed to establish multivariate risk profiles permitting optimal management of patients receiving chronic NSAID therapy.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1990

[Nosologic concept and new developments in the etiopathogenesis of reactive arthritis].

Reactive inflammatory arthritis is caused by extraarticular infection with different arthritogenic microorganisms. The causative bacteria can not be cultured from synovial specimens, but bacterial antigens have been demonstrated in cells of synovial fluid and synovial membrane, respectively. Thus, latent intraarticular infection may be the cause of reactive arthritis. A model of the etiopathogenesis of reactive arthritis is described on the basis of recent immunological and microbiological findings.

Antibodies, Bacterial↗
PubMed1990

[Chlamydia-induced arthritis: diagnosis--follow-up--therapy].

Chlamydia-induced arthritis (CIA) is an inflammatory reactive arthritis caused by extraarticular infection with Chlamydia trachomatis. CIA presents as peripheral arthritis or spondylarthropathy. Extraarticular manifestations are present in most but not all cases, Reiter's syndrome occurs only in a minority of patients. Detection of Chlamydia trachomatis in genitourinary smears and demonstration of serum-antibodies against chlamydial antigens lead to diagnosis. Analysis of synovial fluid reveals nonpurulent inflammatory synovitis and, in some cases, chlamydial antigen has been demonstrated in synovial specimens. The therapy of CIA combines physical medicine, NSAID and shortterm antibiotic treatment of the genitourinary infection. Whether longterm antibiotic therapy or-in chronic cases--DMARDs are successful, needs further investigation.

Arthritis, Infectious↗
PubMed1990

[Yersinia-induced arthritis: new knowledge of pathogenesis, diagnosis and therapy].

Yersinia infections have been identified in rising incidence as the cause of acute or subacute intestinal or extraintestinal diseases in the past two decades. Immunopathological manifestations of Yersinia infections, e.g. Yersinia-induced arthritis, have evoked special interest among clinicians and microbiologists. Beneath epidemiological and clinical characteristics this review focuses on recent progress in pathogenesis and serological and immunohistological diagnosis of Yersiniosis. Possible consequences for newly therapeutical approaches in chronic Yersinia-induced arthritis and spondarthritis were discussed.

Antibodies, Bacterial↗
PubMed1990

[Mycoplasmas and arthritis].

Since 1898 Mycoplasmas are known triggers of different diseases in various animal species. In man they can cause among others non-gonococcal urethritis. In addition they are discussed as triggering agents of arthritis. Besides septic arthritides in immunocompromised patients with hypogammaglobulinemia, they might be causative agents in sexually acquired reactive arthritis, as in Reiter's syndrome. Various diagnostic tests are available. Antibiotic therapy is derived from experience with urogenital infections, proved investigations are pending.

Agammaglobulinemia↗