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Biomedical subjects

H Zauberman

Publications and source records attributed to H Zauberman.

At least 37 records · Page 2Linked to original sources
PubMed1986

Use of infant and child corneas for grafting.

Six corneal transplants, for which donor material was taken from infants or children, were grafted in adults with different types of corneal pathology. Acceptable mean keratometric readings of 45.8 diopters were obtained 6 months after surgery, very similar to those of grafted corneas taken from adults. After 3 years of follow-up, we found complications similar to those of corneas taken from adult donors. No technical problems were encountered while using infants' or children's donor material. We suggest that this type of donor be considered for corneal transplantation in countries where sufficient adult corneas are not available.

Adult↗
PubMed1985

Effects of systemic administration of Chlorambucil and topical application of Cyclosporin A on corneal graft survival in rabbits.

The effects of topically administered Cyclosporin A (Sandoz, Switzerland) and of systemically administered Chlorambucil (Burroughs Wellcome, UK) (2 mg/kg per day) were studied for 6 weeks in 32 rabbits that underwent penetrating corneal graft in one eye, followed 2 weeks later by a skin graft from the donor animal. Nine rabbits were topically treated with 1% Cyclosporin A solution five times daily for 6 weeks. Of these, three eyes showed no rejection; four eyes Grade 1-2 rejection; one eye Grade 3 rejection; and one eye Grade 4 rejection. Of the seven eyes systemically treated with Chlorambucil, three eyes showed no rejection; three eyes Grade 1-2 rejection; and one eye Grade 3 rejection. No animal showed total rejection (Grade 4). The results indicate that both compounds have a beneficial effect on corneal grafts challenged by a second-set rejection.

Administration, Topical↗
PubMed1985

Disappearance of keratic precipitates after intraocular surgery.

Two patients presenting with signs of anterior uveitis and keratic precipitates underwent intraocular surgery. When the bandages were changed, one day after surgery, it was observed that all the keratic precipitates had disappeared. The KPs did not reappear, and the eyes remained free of inflammation in the anterior segment during a six-month follow-up.

Adult↗
PubMed1985

Controlled retrobulbar anesthesia for ECCE and IOL implantation.

A method of controlled retrobulbar anesthesia was used in 20 patients undergoing extracapsular cataract extraction with intraocular lens implantation. The method includes: leaving the pupil undilated before anesthesia; applying topical anesthetic to the conjunctiva; injecting about 0.25 ml of anesthesia through the non-sensitive conjunctiva into the muscle cone, then waiting until the pupil becomes dilated before injecting an additional 1.5 ml; injecting 0.25 ml anesthesia under the conjunctiva and into the tendon of the superior rectus muscle; and applying short-acting mydriatics after the injection. This method is almost painless and does not result in increased intraocular pressure after injection. Massage or compression to soften the eye is not required, and there is excellent anesthesia and akinesia.

Adult↗
PubMed1984

Perfusion of occluded retinal veins in the cat's eye.

The organisation and adherence of a clot induced experimentally in the retinal vein of a cat was studied in vitro. For this purpose a retinal vein was treated in vivo with argon laser photocoagulation in 31 eyes, and each eye was removed at periods of time varying between 3 hours and 7 days after treatment. The freshly enucleated eye was then placed in a perfusion chamber with the cornea under a contact lens, and the retinal vessels were perfused under direct microscopic visualisation. It appears that the hydrostatic pressure and flow needed to perfuse the obstructed vein has to be increased with elapsing time, and that 7 days after laser treatment the retinal vessel becomes permanently occluded.

Animals↗
PubMed1984

Topical indomethacin effect on neovascularisation of the cornea and on prostaglandin E2 levels.

The effect of indomethacin 1% drops against a placebo (NaCl 0.9% solution) was tested in rabbits' corneas injured by a standardized chemical burn. The corneas treated with indomethacin 1% had less neovascularisation and a much smaller increase in the PGE2 levels as compared with the control fellow eyes treated with a placebo. It appears that indomethacin 1% drops have a clear effect on the inflammatory response of the cornea and deserve a clinical trial in selected patients suffering from corneal inflammatory changes.

Administration, Topical↗
PubMed1984

Association between drusen and some of the risk factors for coronary artery disease.

The possible association between coronary artery disease risk factors and drusen was examined in 149 Jewish adults, of both sexes and from different ethnic origins, aged 55 years and above. Areas of drusen were examined 5 degrees and 25 degrees around the macula. Risk factors were examined according to standard procedure used by Lipid Research Clinics. Statistical analysis, including comparison of groups with and without drusen by Student's t test, Pearson's correlation coefficient and step-wise multiple regression analysis, showed similar associations. The multiple regression showed a significant association between drusen and diastolic blood pressure in both males and females and association with glucose only in females.

Blood Pressure↗
PubMed1984

Corneal graft transparency: is 100% an achievable goal?

In a series of 56 patients who underwent penetrating keratoplasty in 86 eyes, 96% of the grafted corneas achieved clarity during a follow-up period of 6 months to 6 years. The reason for this high success rate was the very strict patient selection, which almost entirely excluded cases with dry eye syndrome, active inflammation of the eye and elevated intraocular pressure. Donor material was also very carefully selected.

Acetazolamide↗
PubMed1983

Association between corneal arcus and some of the risk factors for coronary artery disease.

The relationships between coronary artery disease risk factors and corneal arcus were examined in 150 adults aged 55 years and above of both sexes and from different ethnic origins. The width of the corneal arcus was measured accurately by a digitiser, and the risk factors for coronary artery disease were examined according to the standard procedure used by the Lipid Research Clinics. The results show that the corneal arcus is more frequent in males; the frequency and size of corneal arcus are positively associated with age; there is a positive correlation between the size of corneal arcus and the levels of cholesterol and low-density lipoprotein in males; and that there is negative correlation between corneal arcus and diastolic blood pressure in both sexes. No associations were found between corneal arcus and other coronary artery disease risk factors such as triglyceride, high-density lipoprotein, very low-density lipoprotein, weight, Quetelet's ratio, glucose, and smoking.

Age Factors↗
PubMed1982

Expulsive choroidal haemorrhage: an experimental study.

The closure of 2 or more vortex veins in rabbits' eyes results in a persistent rise in intraocular pressure. In these circumstances a small opening into the anterior chamber at the corneoscleral limbus resulted in an iris prolapse, while a larger limbal wound was immediately followed by a massive choroidal expulsive haemorrhage. It appears from this experimental study that a definite and persistent rise in intraocular pressure could be a sign of impaired venous outflow and that the occurrence of an iris prolapse after small limbal opening into the anterior chamber should prompt us to examine the fundus of the eye and look for a choroidal complication. It is possible that the present set of experiments is relevant to the mechanism of expulsive haemorrhage in man.

Animals↗
PubMed1981

Experimental vascular occlusion in hypercholesterolemic rabbits.

Rabbits fed a diet rich in cholesterol developed hypercholesterolemia and atheromas in the cornea, sclera, iris, ciliary body, and choroid, and a few synchysis scintillans in the vitreous. The fellow eye of these rabbits, in which one nasal vortex vein was occluded, developed far more severe changes in all the above-mentioned eye tissues, especially over the sector of the eye drained by the occluded vein. In hypercholesterolemic rabbits in which a short posterior ciliary artery was occluded, the ischemic area of the choroid was gradually seem to become infiltrated with large crystalline particles. The combination of abnormal blood flow and hypercholesterolemia gives rise to an exaggerated deposition of extravascular lipid material. This experimental model is probably relevant to such human conditions as drusen and lipoid deposition in the choroid and cornea and the formation of asteroid hyalosis.

Animals↗
PubMed1980

Corneal transplantation following prolonged storage in M-K medium.

A successful penetrating keratoplasty was performed on a 25-year-old keratoconus patient inadvertently using a 79-year-old donor cornea which had been stored for 32 days at 4 degrees C in M-K medium. A thin, clear graft ten months postoperatively suggested either recovery of the original donor endothelium or possible host endothelial cell migration. The clinical advantages of prolonged M-K storage beyond seven days versus the increased risks of endothelial decompensation and secondary infection are reviewed.

Adult↗
PubMed1979

Oculographic automatic perimetry in glaucoma visual field screening: a clinical study--preliminary results in glaucoma patients.

An automatic method for visual field screening using oculographic potentials have been evaluated on 12 eyes of 65 glaucoma patients. The oculographic perimeter records, plotting the central 22 degrees of the visual field, have been compared with Armaly's manual selective perimetry performed by the Goldman Perimeter. In spite of different testing standards of both methods, equivalent pathological field defects were demonstrated in 72% of the eyes following the first examination. Successive plottings with the automatic method improved the results considerably. The method has proved to be a reliable objective automatic test. Further development is suggested through which the procedure might be useful for glaucoma screening in the future.

Adolescent↗
PubMed1979

Diurnal changes of the intraocular pressure of patients with angle-closure glaucoma.

The diurnal curves of 21 patients (40 eyes) with angle-closure glaucoma and of 21 normotensive subjects (42 eyes) were studied. The patients with angle-closure glaucoma had a V-shaped diurnal curve that was completely different from the diurnal curve of the normotensive subjects. Most of the eyes of the patients with angle-closure glaucoma had a diurnal change of the intraocular pressure of 8 mmHg or more, while in the normotensive subjects only 1 eye had a diurnal change as large as 8 mmHg.

Adult↗
PubMed1977

Automatic testing of the visual field using electro-oculographic potentials.

The central visual field is tested using static perimetry on a tangent screen located 1 m from the patient. During the test electro-oculographic (EOG) potentials, associated with eye movements, are recorded. For this purpose two pairs of electrodes are placed in such a way that one pair records the vertical and the other the horizontal component of the EOG potential. The EOG signals that are produced when the tested eye moves toward the light target on the screen are digitized and fed into a computer programmed to relate each pair of signals to the specific lamp on the tangent screen. The results of the test appear on a computer-printed chart that shows the distribution of the lamps on the testing board together with the information whether the lamp was seen by the subject. This method of visual field testing is both objective and automatic.

Automation↗