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Biomedical subjects

H Zattara

Publications and source records attributed to H Zattara.

7 recordsLinked to original sources
PubMed1992

[Laser therapy in the prevention and treatment of mucositis caused by anticancer chemotherapy].

The appearance of mucositis is a frequent and painful secondary effect of anticancer chemotherapy. Patients who develop oral toxicity during the first course of treatment will almost assuredly show identical side effects during each subsequent course unless the drugs are changed or the doses are lowered. In the absence of an efficacious antidote or preventive prophylaxis for such lesions to date, this report presents the results of a preliminary retrospective non-randomized study of the effect of soft-laser treatments on mucositis in cancer patients receiving combination chemotherapy, including 5-fluorouracil. Iatrogenic mucositis was observed during 43% of 53 chemotherapy cycles in the case control population. Curative laser therapy reduced the time to repair lesions and the rate of therapeutic modifications. For patients who received soft-laser therapy as a preventive measure, the incidence of oral complications was reduced to 6% during 101 cycles of chemotherapy. All of these patients, even those who have encountered mucositis before receiving preventive laser therapy, terminated their cancer therapy as originally scheduled. Well designed and carefully controlled trials will be necessary to define the place of helium-neon laser therapy in the repair and prevention of oral complications due to cancer chemotherapy.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1979

[Recent advances in the therapy of osteoradionecrosis of the maxillomandibular bones (author's transl)].

In spite of the considerable technical progress made over the last few years, no type of irradiation used at the present time for treating malignant tumors in the maxillofacial region can protect the patient from the always dreaded appearance of a secondary osteoradionecrosis of the maxillomandibular bones. Extablished osteoradionecrosis is not a "true" necrosis of these bones but a particularly severe osteitis which evolves in bone, which is pathological because it has been irradiated, and is surrounded by tissues which are also pathological for the same reason. Very high doses of antibiotics, comparable to those used in the treatment of osteomyelitis, mandibular resection by the endobuccal route, and the possibility of treating perimaxillomandibular tissues by reconstructive surgery, have completely transformed the prognosis of this dreaded affection, which is being increasingly prevented by daily fluoride applications applied locally.

Anti-Bacterial Agents↗