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Biomedical subjects

H Zöller

Publications and source records attributed to H Zöller.

At least 19 recordsLinked to original sources
PubMed1986

Clotting properties in diverse valve prostheses.

With regard to both hemolysis and thrombophilia the St. Jude Medical prosthesis shows only minor alterations in comparison to normals. The most significant alterations concerning platelets and hemolysis have been found in patients with Starr-Edwards prostheses. Even in tissue valves, major alterations of the clotting system and chronic intravascular hemolysis were found. For long-term anticoagulation in mechanical prostheses--even with sinus rhythm--vitamin K antagonists should be preferred. During the first months of gravidity only heparin can be recommended. In St. Jude Medical valves anticoagulation with dicumarolum must be recommended; whether antiaggregation drugs can be recommended is not yet proved. Anticoagulation may be discontinued three months after tissue valve implantation if there are no additional risk factors. Diminishing platelet adhesivity in tissue valves may support these conclusions.

Bioprosthesis↗
PubMed1984

Diclofenac sodium: blood concentration of the slow-release form and influence on the metabolism of kallikrein.

The blood concentration of the slow-release formulation of diclofenac sodium (Voltaren) has been determined in 10 patients at various intervals over a period of 22 days. In parallel, the influence of diclofenac on the kallikrein-kinin system was investigated since important interactions between the prostaglandins and kallikrein are known. The peak concentration of the slow-release formulation was significantly decreased compared with data of the standard formulation from other studies and the peak was observed later. The areas under the concentration curves were, however, similar. No signs of drug cumulation were observed during the treatment. The kallikrein concentration decreased after one week in plasma and after two weeks in urine. The plasma concentration of kallikrein reaches control level again after two weeks. Its urine excretion was increased to control levels after the third week. These changes in the kallikrein-kinin system did not reach the level of significance. It is concluded that diclofenac sodium has only a short-term influence on the kallikrein-kinin system.

Adult↗
PubMed1981

[How strongly does heavy work in the heat affect metabolism?].

The study covered 39 acclimatised workers of a ball-bearing forge, aged 39,03 +/- 9,95 years. Temperature of the air, relative humidity and air speed were measured immediately at work. Additionally electrocardiogram, heart rate and temperature of the skin were continuously transmitted by telemetry. Before and at the end of the shift analysis of blood pressure, heart rate, electrocardiogram, blood cells and coagulation, serum acidity and a great number of other metabolic parameters was performed. The netto calories were calculated as 3250 kcal/8 hours (= 13585 kJ/8 hours). Hematological analysis demonstrated a tendency to increase of leucocytes favouring neutrophil granulocytes. The main alterations comprised decrease of actual pH, base excess and standard bicarbonate. Furthermore serum lactate and triglycerides increased, creatinine attained the upper limit of the normal range, mineralogram remained unchanged by drinking ad libitum. The so called "liver enzymes" remained stable. As to circulatory parameters systolic blood pressure slightly declined whilst heart rate increased.

Acid-Base Equilibrium↗
PubMed1979

[Hemorrhagic diathesis in patients with malignant neoplasms (author's transl)].

Clotting analysis in 30 patients with bleeding complications in malignant hematological diseases revealed the following troubles: The global tests, Quick's index and partial thromboplastin time markedly differed from normal. Activity of clotting factors revealed hypo- or hyperfibrinogenemia, disturbances of the prothrombin complex (factors II, VII, IX and X), decrease of factors V, VIII, XII. Factor XI (= PTA) was not diminished in any case. Regarding the fibrin-stabilizing factor (factor XIII), its activity was significantly decreased in 30 patients with solid tumors and in 30 patients with hemoblastoses. Faulty clotting balance was characterized by hyperfibrinolysis or disseminated intravascular coagulation (DIC) accompanied by reactive hyperfibrinolysis. About one quarter of the patients with malignant disturbances of the hematopoetic system demonstrated (mostly amegacaryocyte) thrombocytopenia. Finally, treatment of bleeding complications in malignant neoplastic diseases is pointed out.

Blood Coagulation Tests↗
PubMed1978

[Coagulation and fibrinolytic system in the vascular risks diabetes mellitus and hyperlipoproteinemia (author's transl)].

42 patients with minifest diabetes mellitus and 42 patients with primary hyperlipoproteinemia type II, IV or V (Fredickson) underwent analysis of cholesterol, triglycerides and agar-agarosegel-lipoprotein electrophoresis. Simultaneously clotting factors I--XIII, platelet count and aggregability, fibrinolytic activity and antithrombins were determined. The most accentuated disturbances were seen in hyperlipoproteinemia type II and in diabetes mellitus comprising increase of fibrinogen content, platelet reduction and enhanced platelet aggregability, hypofibrinolysis. Only minor differences of certain clotting factors could be detected comparing diabetes mellitus and hyperlipoproteinemia type II. Diabetes mellitus being complicated by micro- or macroangiopathia revealed additional significant alterations such as more pronounced increase of fibrinogen, further platelet reduction and aggregability. Increase of fibrinogen, platelt disturbances, hypofibrinolysis and alterations of antithrombin activity in connection with metabolic diseases may be regarded as additional risk to vascular complications.

Adult↗
PubMed1976

[Plasma fibrinogen activity in diabetes mellitus, hyperlipoproteinemia and hyperuricemia (author's transl)].

Plasma fibrinogen content was measured in 20 normal subjects, 20 patients with diabetes mellitus, 20 patients with hyperlipoproteinemia type II or IV (Fredrickson) and 10 patients with hyperuricemia. These vascular risks were accompanied by significant increase of plasma fibrinogen in comparison with the normal collective. The highest fibrinogen concentrations were found in diabetics, followed by hyperuricemias and hyperlipoproteinemias. The importance of coagulation disturbances is discussed in regard of angiopathogenesis.

Adult↗