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Biomedical subjects

H Yoshihara

Publications and source records attributed to H Yoshihara.

144 records · Page 8Linked to original sources
PubMed1975

Medial forebrain bundle projections to the nucleus of the diagonal band of Broca.

The electrophysiological characteristics of the medical forebrain bundle (MFB) projections to the nucleus of the diagonal band of Broca (nDBB) were studied in acutely prepared cats. MFB stimulation evoked field potentials which consisted of a large negative wave followed by a shallow positivity. Extracellular unitary discharges appeared out of the negativity. In addition, intracellularly recorded EPSPs showed no significant shift in the latency to onset with changes in stimulus intensity. These observations indicate that at least some of the MFB projections to the nDBB are excitatory with respect to their target cells.

Action Potentials↗
PubMedDate not supplied

Hepatic hemodynamics in alcoholic liver injuries assessed by reflectance spectrophotometry.

We have investigated the hepatic hemodynamics by reflectance spectrophotometry in patients with alcoholic liver disease. The analysis of 32 cases has shown that the estimated regional hepatic tissue blood hemoglobin concentration, expressed as a difference in absorbance between 569 and 650 nm (delta Er569-650), decreased significantly with progress of fibrosis in the liver, suggesting the relative compression of the vascular compartment due to the progress of alcoholic liver disease. The estimated hepatic oxygen consumption also decreased with progress of fibrosis in the liver. The estimated hepatic oxygen consumption correlated positively with prothrombin time and serum albumin level, and negatively with the fifteen minute retention rate of indocyanine green. Thus, it is concluded that the imbalance between supply and utilization of oxygen in the liver may have an important role in the progress of alcoholic liver disease.

Adult↗
PubMedDate not supplied

Effect of alcohol ingestion on portal venous blood flow in healthy volunteers: comparison between the subjects with and without ALDH I isozyme.

Effect of alcohol ingestion (25 g ethanol) on portal venous blood flow was investigated in healthy subjects using an ultrasonic pulsed doppler method. It was found that; (1) portal blood flow increased by 24% at 30 minutes and returned to the basal level at 60 minutes after alcohol ingestion; (2) there was no significant difference in the effect of alcohol ingestion on portal blood flow between the subjects with and without ALDH I isozyme; (3) blood ethanol levels correlated with portal blood flow at 30 minutes after alcohol ingestion, while this correlation was not observed at 60 minutes thereafter; and (4) blood acetaldehyde levels did not correlate with portal blood flow either at 30 minutes or at 60 minutes following alcohol ingestion. In conclusion, the portal blood flow increases following alcohol ingestion which is not associated with the increase in the blood acetaldehyde level.

Acetaldehyde↗
PubMedDate not supplied

Detection of total assist and sucking points based on pulsatility of a continuous flow artificial heart: in vitro evaluation.

We investigated the basic characteristics of the pulsatility of motor current with an in vitro mock circuit that consists of a sac-type pulsatile pump (simulating the natural left ventricle), three reservoirs, and our mixed flow pump (MFP). There are three alternatives at the inlet of the MFP: 1) the left atrium (LA), 2) the left ventricle (LV), and 3) both (LALV). The motor current waveform was monitored. The pump speed of the MFP was changed from 0 to 7,000 rpm. We calculated the index of motor current amplitude (ICA), which was obtained from the amplitude of the motor current waveform divided by the simultaneous mean value. The ICA plotted against the pump speed had a peak point (t-point) that highly corresponded with the turning point from partial to total left heart assistance. The ICA also had a second specific point (s-point) that corresponded with the beginning of severe sucking. In LV and LALV aortic bypass, t- and s-points could clearly be detected. In LA aortic bypass, however, early and severe sucking occurred, and t- and s-points were not manifest. These data suggest that the assist status of continuous flow artificial heart can be estimated by detecting the t- and s-points.

Blood Flow Velocity↗
PubMedDate not supplied

[Chemotherapy in hemodialysis patient with metastatic testicular cancer; pharmacokinetics of etoposide and cisplatin].

The pharmacokinetics of intravenously administrated cisplatin and etoposide were studied in a patient with seminoma (stage IIIA) receiving hemodialysis for chronic renal failure. The treatment schedule was as follows: 7 mg/m2 of cisplatin at day 1, 3, 5; 14 mg/m2 of cisplatin at day 2, 4; 70 mg/m2 of etoposide at day 1-5; hemodialysis at day 2, 4. After the treatment myelosuppression was very strong. So the patient were received another treatment of smaller doses of cisplatin and etoposide in three courses. The other schedule was as follows: 14 mg/m2 of cisplatin at day 1, 3, 5; 35 mg/m2 of etoposide at day 1-5; hemodialysis at day 1, 3, 5. The area under the blood concentration-time curve (AUC) of free-cisplatin was 6.82 micrograms.hr/ml in first course, 4.07 micrograms.hr/ml in second course. The peak concentration of peripheral blood free-cisplatin was 0.58 microgram/ml in first course, 0.43 microgram/ml in second course. The AUC of etoposide was 241.9 micrograms.hr/ml in first course, 216.9 micrograms.hr/ml in second course. After treatment CR was observed and there was no recurrence for five years. In conclusion, it was considered that cisplatin and etoposide could be given to the patient receiving hemodialysis for chronic renal failure and smaller doses should be given to prevent side effects.

Adult↗