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Biomedical subjects

H Yajima

Publications and source records attributed to H Yajima.

At least 271 records · Page 15Linked to original sources
PubMed1982

Immunohistochemical studies on enteric substance P of extrinsic origin in the cat.

The origin of substance P (SP)-like immunoreactivity in the Auerbach's plexuses of the esophagus, stomach duodenum was examined in the cat. The intensity of the fluorescence and the area of distribution of SP-like immunoreactivity in the Auerbach's plexuses of the cardiac part of the esophagus and the corpus of the stomach were markedly reduced by bilateral ligation of the abdominal vagus nerve, while little change occurred in the antrum of the stomach and the duodenum. After splanchnic nerve ligation or celiac ganglionectomy, the SP-like immunoreactivity in the Auerbach's plexuses of the antrum of the stomach and the duodenum was markedly reduced, whereas that in the esophagus and the corpus of the stomach was only slightly attenuated. Intense SP-like immunoreactivity was observed in the portions of the abdominal vagus and splanchnic nerve cranial to the ligation. This the Auerbach's plexuses of the esophagus, stomach and duodenum were considered to contain SP transported through the vagus and splanchnic nerve. It was also indicated experimentally that the SP-like immunoreactive fibers in the auerbach's plexus arose from the nodose and spinal ganglia as well as from the dorsal vagus nucleus in the medulla oblongata.

Animals↗
PubMed1982

Kassinin: stimulation of insulin and glucagon secretion in the rat.

The effect of the newly discovered tachykinin dodecapeptide kassinin on endocrine pancreatic function was examined in the rat and compared to that of substance P, a neuropeptide which is structurally closely related to kassinin. Kassinin, injected iv in graded doses 10, 20, and 30 min before blood collection, significantly increased both plasma insulin and plasma glucagon in a dose-related fashion. The largest dose examined (10 micrograms) increased plasma insulin by 275% and plasma glucagon by 77%. In contrast, iv injections of equimolar doses of substance P did not affect either hormone. However, both kassinin and substance P increased plasma glucose levels in a dose-dependent fashion. Kassinin appears to have biological actions on the endocrine pancreas which clearly can be distinguished from those of substance P. Should kassinin be present in mammalian tissue and show a distribution similar to that of other neuropeptides, it may play a role in the physiological regulation of carbohydrate metabolism.

Animals↗
PubMed1982

Growth hormone, prolactin and FSH release by the tachykinin dodecapeptide kassinin in the rat.

The effect of equimolar doses of kassinin, a newly discovered tachykinin dodecapeptide, and substance P on serum growth hormone, prolactin and FSH was examined in adult male Fischer 344 rats. The two peptides were injected intravenously 10 or 30 min prior to blood collection by decapitation. Kassinin in concentrations of 0.3 and 3.0 micrograms/100 g B.W., potently stimulated release of growth hormone. Both kassinin and substance P decreased prolactin at the lowest dose. An increase of serum prolactin above control values by both peptides was observed at the highest dose administered. However, this increase with the highest dose depended on the time of blood collection. Serum FSH was increased only by injection of the highest dose of kassinin or substance P. These results demonstrate that kassinin and substance P have similar effects on the secretion of these hormones. The findings provide further evidence for an involvement of peptidergic neurons in the regulation of pituitary function. Kassinin, if present in central and peripheral neurons of the mammalian central and autonomic nervous system and in the cells of the diffuse neuroendocrine system, could function as a neuropeptide.

Animals↗