Cloning and expression of the adenine phosphoribosyltransferase gene from Leishmania donovani.
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Adenine Phosphoribosyltransferase↗
Biomedical subjects
H Y Hwang
Publications and source records attributed to H Y Hwang.
SolI, a novel isoschizomer of BamHI isolated from Streptoverticillium olivoverticillatum.
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Actinomycetales↗
Calcified gastric carcinoma: CT findings.
The computed tomographic (CT) findings of 13 cases of calcified gastric carcinoma were analyzed retrospectively. Eleven cases were confirmed as a mucinous adenocarcinoma by surgery (three cases), or endoscopic biopsy (eight cases). Two cases were diagnosed as adenocarcinoma by endoscopic biopsy. In all cases the calcifications were of the punctate or miliary shape and the size varied from 1-3 mm in diameter. The calcifications were located in the thickened gastric wall in all cases, and were seen in metastatic lesions such as lymph nodes and the liver in two cases. In 10 cases, some tumor portions showed lower attenuation number than that of the muscle on CT scans, and corresponded to mucin pool in tumor portions histologically. Twelve cases were in inoperable advanced stage.
Adenocarcinoma, Mucinous↗
Uterine metastasis from stomach cancer: radiological findings.
The uterus is an unusual site for metastasis from an extrapelvic neoplasm. We report a case of uterine metastasis with extensive calcification. Plain radiography, ultrasonography and CT showed diffuse calcification within the uterine wall and T2-weighted MR images showed abnormally high signal intensity of the entire myometrium.
Adenocarcinoma↗
Nutrient reabsorption of intestine in vitro: effects of ethanol and caffeine.
We studied the effect of ethanol and caffeine on the intestinal reabsorption (jejunum from SD rats) of glucose (Glu) and amino acids. Since most of the studies on the effect of ethanol utilized high concentration, we first characterized the effect of 8% (approximately 1.4 M) ethanol on the activity of Na(+)-coupled nutrient transport. Consistent with previous reports, ethanol (greater than 1 M) was found to inhibit the uptake rates of glucose and its non-metabolizable analogue 3-O-methyl-glucose (3-OMG) by 30%, while leucine (Leu) uptake was inhibited by 60%. Phloridzin, a specific inhibitor for Na(+)-coupled sugar transport, at 1 mM concentration could inhibit Glu and 3-OMG uptake by more than 60% without affecting Leu uptake. We then compared the effects of various concentrations of ethanol on about 20 intestinal segments taken from the same animal. We consistently observed transport inhibition at high concentration of ethanol but at low concentrations (up to 200 mM), there was no consistent effect, while phloridzin or low-Na media (86% of Na replaced by choline) significantly reduced the rate of nutrient uptake in the same experiment. Thus, it appeared that low concentrations of ethanol had no significant effect on Na(+)-coupled nutrient uptake. We also determined the effect of caffeine on intestinal 3-OMG uptake. At concentration of 0.05 mM, caffeine inhibited 3-OMG uptake by about 15% (p less than 0.05). The level of inhibition was not significantly different at 0.5 mM, but a slightly higher level of inhibition (20%) was reached at 5 mM. The action of caffeine could be mimicked by dibutyryl cAMP (1 mM).
3-O-Methylglucose↗
Methods of vascular pedicle coverage.
Based on our clinical experience, various methods of donor or recipient vascular pedicle coverage for an arterialized or free flap are reported. The vascular pedicle may be placed in the subcutaneous space either by incising the skin along the full length of the vascular route or by passing it through a subcutaneous tunnel. It has been our experience that the vascular pedicle can also be covered by either a local flap or a free skin graft. On rare occasions, a narrow skin flap strip including the vascular pedicle can be lifted en bloc and rotated toward the base of the area transferred.
Adult↗
Portal vein aneurysm of the umbilical portion: imaging features and the relationship with portal vein anomalies.
BACKGROUND: We evaluated the imaging features of portal vein aneurysm occurring at the umbilical portion and the relation between portal vein aneurysm of the umbilical portion and portal vein anomaly. METHODS: Retrograde analysis was performed in 18 patients with portal vein aneurysm of the umbilical portion of the portal vein. We analyzed the size, shape, and imaging findings of portal vein aneurysm. In addition, we evaluated associated portal vein anomalies, specifically, the branching pattern of the intrahepatic portal vein and the position of the umbilical portion of the left portal vein. RESULTS: The diameter of the portal vein aneurysm ranged from 1.5 to 2.2 cm and the shape of the portal vein aneurysm was saccular (n = 14) or fusiform (n = 4). Imaging findings of the portal vein aneurysm of the umbilical portion were typical for its vascular nature. Portal vein anomalies were seen in eight of 18 patients (44%): the right anterior segmental portal vein (n = 7) or the right anterior and posterior segmental portal veins (n = 1) originating from the umbilical portion of the left portal vein and a rightward deviation of the umbilical portion of the left portal vein (n = 4). CONCLUSION: Due to its vascular nature, noninvasive diagnostic modalities can enable the detection of portal vein aneurysm of the umbilical portion, and there is a close relation between portal vein aneurysm of the umbilical portion and portal vein anomaly.
Adult↗
Standardization of 125I and 238Pu.
A simple distance-variable detection table on which two detectors can be mounted and moved back and forth facing each other centred on a sample source has been constructed for photon-photon and alpha-photon coincidence counting for 125I and 238Pu, respectively. Two NaI(Tl) detectors were used for the standardization of 125I. A Si detector and an NaI(Tl) detector were employed for the standardization of 238Pu. The NaI(Tl) detectors have a very thin aluminium window for measuring low-energy photons from 125I and 238Pu while the Si-detector is a usable-in-air ion-implanted detector for alpha particles from 238Pu. A thin collodion film was used for 238Pu samples, whereas a thick polyester film was used for 125I samples to prevent 125I from leaking from the sample. The key comparison result of 125I showed good agreement, and the result of 238Pu was also compared with that of liquid scintillation counting.
Algorithms↗
Development of MCTS technique for 3-PM liquid scintillation counting.
We have developed a multi-channel time scaling method that is suitable for activity measurement of beta emitting nuclides by means of 3-PM Liquid Scintillation Counting, using non-extending dead times and linear amplifiers. Since it enables to obtain the accidental coincidences directly, the true values for both double and triple coincidences are determined by simply taking into account the correction due to dead times. The advantages of the method are demonstrated by studying the activity of 204Tl and 14C. The measured results were compared with those derived by using the mathematical formulae.
Journal Article↗