Biomedical subjects
Publications and source records attributed to H Wojciechowska.
Syntheses of the peptides with sequences postulated for active and inactive isomer of edeine D were carried out. The peptides obtained were identical with natural product in regard to chromatographic and electrophoretic properties. Biological data for synthesized compounds confirmed that in active and inactive isomer isoserine is linked with the alpha- or beta-amino group of alpha, beta-diaminopropionic acid, respectively.
The peptide antibiotic edeine F produced by Bacillus brevis Vm4, one of the components of edeine antibiotics complex, was isolated from a fermentation broth and was also obtained by amidination of edeine D. Edeine F is composed of amino acids: (S)-beta-phenyl-beta-alanine, (S)-isoserine, (S)-2,3-diaminopropionic acid, (2R,6S)-diamino-(7R)-hydroxyazelaic acid, glycine and a polyamine guanidylspermidine. Enzymatic degradation of antibiotic with carboxypeptidase B, dinitrophenylation of edeine and of its enzymatic degradation products and synthesis of edeine F from edeine D of known structure permitted to postulate the chemical structure for edeine F.
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A study aimed at evaluating an effect of amrinone of blood circulation dynamics (cardiac output), using impedance ++rheography. The study involved patients with acute, congestive cardiac failure (NYHA III-IV degrees). Cardiac output was measured prior to and 3 and 24 hours following amrinone administration. A favourable effect of a 24-hour i.v. infusion of amrinone on blood circulation dynamics was confirmed. The drug proved to be proarrhythmic.