Search PubMed⌕ Search

Biomedical subjects

H Wiseman

Publications and source records attributed to H Wiseman.

71 records · Page 4Linked to original sources
PubMed1991

The antioxidant action of ketoconazole and related azoles: comparison with tamoxifen and cholesterol.

The azole antifungal drug ketoconazole was found to inhibit Fe(III)-ascorbate dependent lipid peroxidation using either rat liver microsomes or ox-brain phospholipid liposomes as the substrate. It also inhibited microsomal peroxidation induced by the Fe(III)-ADP/NADPH system. The related azoles, miconazole and clotrimazole, were much weaker inhibitors than ketoconazole. Ketoconazole was approximately equipotent with the triphenylethylene anticancer drug tamoxifen in the microsomal system and was almost as effective as 4-hydroxytamoxifen in the liposomal system. Ketoconazole introduced into phospholipid liposomes during their preparation inhibited Fe(III)-ascorbate induced lipid peroxidation to a greater extent than similarly introduced cholesterol, ergosterol or tamoxifen. Miconazole and clotrimazole were again poor inhibitors of lipid peroxidation in this system. These antioxidant effects of ketoconazole may be due to membrane stabilization in the systems used. The implications of our findings for the clinical applications of these drugs are discussed.

Animals↗
PubMed1990

Mechanism of inhibition of lipid peroxidation by tamoxifen and 4-hydroxytamoxifen introduced into liposomes. Similarity to cholesterol and ergosterol.

The anticancer drug tamoxifen when introduced into phospholipid liposomes during their preparation inhibited Fe(III)-ascorbate induced lipid peroxidation to a greater extent than similarly introduced cholesterol. Ergosterol was equipotent with tamoxifen, but much less effective than 4-hydroxytamoxifen. Possible mechanisms underlying these effects are discussed in relation to structural mimicry of the sterols by these triphenylethylene drugs as membrane stabilizers against lipid peroxidation.

Cholesterol↗
PubMed1989

Sequential analyses of therapist-client interaction during change events: a task-focused approach.

In this article, we describe a task-focused approach that uses sequential analyses as deductive techniques for studying therapist-client interactions in the context of clinical microtheories of change events. The methodology is demonstrated in a study of a class of change events in client-centered therapy referred to as the resolution of problematic reactions. Logit-loglinear analysis and binomial z scores were used to test the effects of therapist behavior, assessed by therapist vocal quality and by the therapist task-relevant system, on client process assessed by client vocal quality and by the Experiencing Scale. The results indicated (a) that therapist productive voice facilitated a shift from poor to productive client voice and a shift from low to intermediate experiencing and (b) that therapist task-specific interventions directed toward resolution facilitated shifts to high experiencing. This task-focused approach to sequential analyses has the potential to yield clinically and theoretically relevant findings.

Adaptation, Psychological↗
PubMed1986

Trend associations of smoking with maternal, fetal, and neonatal morbidity.

Smoking habits, prenatal health, and pregnancy outcome were surveyed among 1700 nulliparous women. During pregnancy, increases in levels of hemoglobin and hematocrit and the frequency of women reporting bleeding and decreases in diastolic pressure and frequency of toxemia were observed with increased maternal smoking. A higher frequency of fetal bradycardia was detected among women smoking greater than or equal to one-half pack per day. With increased smoking there was an increased frequency of abnormal placentas. Mean birth weight and crown-heel length decreased with increased smoking, and neonates born to women smoking greater than or equal to one-half pack per day had a higher frequency of jaundice. The association between smoking and reduced birth weight and crown-heel length persisted after controlling for gestational age, maternal weight gain, prenatal visits, and other confounding variables.

Birth Weight↗
PubMedDate not supplied

The effects of chronic childhood illness on families.

Chronic illness in childhood has massive physical, social and psychological effects on families who, in addition to fulfilling their usual duties, roles and obligations, are expected to meet the needs arising from the child's illness. This constitutes a severe disruption to the ordinary continuity of family life. This paper and examines the effect of cystic fibrosis on families. It gives a brief overview of the physiological nature of cystic fibrosis, examines the effect of diagnosis on other members of the family and the process of adjustment they go through to accept the condition. Although CF has been chosen specifically, the effects on the family resemble those of most chronic conditions.

Adaptation, Psychological↗