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Biomedical subjects

H Wilms

Publications and source records attributed to H Wilms.

At least 55 records · Page 3Linked to original sources
PubMed1987

Successful transplantation of adult and fetal mouse pancreas islet cells using anti-class II antibodies.

Fetal pancreas islet tissue of mice is able to proliferate in cell culture. The insulin production after 14 days is sufficient to reverse diabetes mellitus. The immunogenicity is reduced by tissue culture. By using monoclonal antibodies it could be shown that the expression of class II antigens on the surface of the cells is lower after tissue culture than before. Together with complement, the positive cells could be lysed, and transplantation even in completely different mice stems was successful.

Animals↗
PubMed1987

[Aspects of splenic surgery].

OPSI (overwhelming postsplenectomy infection) after traumatic or accidental splenectomy is a very rare but mostly deleterious complication. Conservation of the spleen is preferable to autologous transplantation into the greater omentum. The results at this moment are not clear and emphasize the need for further research.

Humans↗
PubMed1986

[Terminal renal failure in aniridia-Wilms syndrome].

Missing iris combined with debility and incidence of Wilms' tumor seem to be a complex syndrome which appears in 1:100,000 people. It is caused by an interstitial deletion on the short arm of chromosome no. 11. We refer to a patient who developed end-stage renal failure caused by a focal-segmental nephrosclerosis. He underwent renal transplantation because chronic hemodialysis was impossible due to his lack of compliance. The deletion of chromosome 11 could be recognized by chromosomal analysis after transplantation. An aniridia-Wilms' tumor association (AWTA) with following focal segmental nephrosclerosis could be diagnosed.

Adult↗
PubMed1986

Therapy motivation in anorexia nervosa: theory and first empirical results.

Anorexia nervosa patients are considered to be unmotivated for psychotherapy of eating disorders, because they present a lack of understanding and feeling for their disease. In order to objectify this lack of therapy motivation we formulated two questionnaires for patients and therapists. The items were obtained from 15 theoretically determined fields of both intra- and interpersonal subsets of motivation, and a 'motivation profile' was gained. In a first clinical application these profiles are obtained from an anorexia sample at the beginning and at the end of an inpatient treatment and combined with the corresponding therapist ratings. The results are compared with two control groups (preattended psychosomatics and somatic patients). Results collected hereby are used for the improvement of our questionnaires and for suggestions concerning further studies.

Adult↗
PubMed1986

[Sclerosing peritonitis following continuous ambulatory peritoneal dialysis].

Sclerosing peritonitis is a severe complication after CAPD treatment. The visceral peritoneum is thickened and interenteric adhesive parts are found. Myofibroblasts are proliferated and the collageneous tissue is hyperplastic. The mean clinical symptom is the mechanical obstruction of the small bowel. We observed this illness in three out of sixty patients under CAPD. These patients had higher incidence of bacterial peritonitis. In the ascites high concentrations of PG E2 and Thromboxan B2 were observed. After treatment of the infection the concentrations fell down to normal values. Electronoptical observations from peritoneal biopsies showed a proliferation of myofibroblasts and extracellular lysosomes. It is known from these lysosomes that they are able to set free proteasis. These lead to degredation of fibrin and fibrinogen. These splits are mitogen to myofibroblasts. release from HIT cells could also be evoked by the sulphonylureas glibenclamide and tolbutamide and by an increase in concentration of extracellular K+ to 40 mmol/l. The content of cyclic AMP in HIT cells was increased modestly by glucose but not by an increase in extracellular K+. Forskolin elicited a 4-fold increase in cyclic AMP content. We conclude that HIT cells retain the essential features of the insulin secretory response of normal B cells and represent an important tool for further biochemical characterisation of the secretory system.

Adult↗
PubMed1986

[Effect of the angiotensin II analog saralasin before donor nephrectomy on primary transplant function].

Cadaver kidney donors were treated with Angiotensin II-Analogon-Saralasin before nephrectomy in order to reduce the rate of acute renal failure. Eighteen (64.3%) of the recipients of the 30 donor kidneys pretreated with Saralasin were primarily free from dialysis. Six recipients showed acute renal failure. Two donor kidneys never resumed their function and no reports could be obtained on two organs. In the control-group with no pre-treatment, acute renal failure appeared significantly more often (67.3%). Thus only 32.7% of the recipients needed no further dialysis. This difference is statistically significant.

Acute Kidney Injury↗
PubMed1986

[Preventive use of antibiotics in kidney transplantation].

Antibiotic prophylaxis in kidney transplantation is controversial. In a prospective controlled study, 34 cadaveric kidney transplant recipients were investigated. Antibiotic prophylaxis was given in a random order to 16 patients whereas 18 without prophylaxis served as controlls. In 4 of 20 investigated clinical parameters statistically significant differences were found between both groups: the controlls happened to have better initial conditions; perioperative and postoperative better initial conditions; perioperative and postoperative infections were less frequent in the prophylaxis group and more antibiotics postoperatively were needed in the controlls. These findings indicate that antibiotic prophylaxis has a beneficial effect in kidney transplantation.

Bacteriological Techniques↗
PubMed1986

[Local fibrinolytic therapy in thrombotic complications of peritoneovenous shunt].

Since 1981 in the University Hospital of Freiburg 41 patients with ascites have been treated by installation of a peritoneo-venous shunt system. In 9 patients thrombotic complications occurred. Two patients had to undergo a second surgical treatment. Seven patients have been treated by local fibrinolysis. In 6 patients local fibrinolytic therapy was partly or completely successful, in one patient local fibrinolysis was of no therapeutic effect.

Adult↗
PubMed1985

[Peritoneovenous shunt in ascites therapy. Complications and their treatment].

Complications occurred in 29 of 37 patients after ascites retransfusion (n = 16) or introduction of a peritoneovenous shunt (n = 21). Blood clotting disturbances, that could either be successfully treated with drugs or which led to interruption of the reinfusion, appeared in 38%. Estimation of plasminogen proved to be of reliable prognostic value thus enabling prophylactic measures to be taken. Post-operatively 14 patients had transient fever not requiring specific treatment. Local fibrinolysis or shunt revision was successful in three patients with shunt thromboses. According to our experience most complications can be avoided by prophylactic and therapeutic measures.

Adult↗
PubMed1985

[Incidence and clinical relevance of cytomegalovirus diseases using cyclosporine compared to conventional immunosuppression].

Since transplanted patients have been treated with cyclosporin A after kidney transplantation, the whole immunosuppression has changed. Combined with the specific T-cell suppression, steroids were administered in much lower concentrations. ALG and ATG combined with cyclosporin were avoided because of the immunoproliferative syndrome. Changing in immunosuppression reduced the incidence of CMV-infections from 4.3% to 3.1% in our center. Beside the apparent infection, severe illness was significantly reduced. Under conventional immunosuppression, in 1.7% a loss of transplantate could be observed. This was not the case under cyclosporin A. Since half a year the immunosuppression has changed and triple drug usage was common in high responder patients. It seems that CMV-infections will become more relevant than in former days. Important for us is the recognition of risk groups at the point of transplantation. In these patients a passive vaccination with CMV-hyperimmunoglobulin should be performed.

Adrenal Cortex Hormones↗
PubMed1985

Thromboxane B2 and beta 2-microglobulin as early indicators of renal allograft rejection.

In a prospective study the diagnostic value of urinary thromboxane B2 (TXB2) and beta 2-microglobulin (beta MG) in renal allograft rejection was studied in 34 patients after transplantation. Twenty-four episodes of rejection were diagnosed by clinical symptoms. The clinical diagnosis of rejection was confirmed by an increase of urinary TXB2 in 21 (88%) cases. The augmented renal excretion of TXB2 proceded the clinical signs of rejection for 2.0 +/- 0.75 days. The symptoms in the remaining three (12%) cases of supposed allograft rejection without increased urinary TXB2 were caused by non-immunological events (urinary tract infection, acute tubular necrosis). No elevated TXB2 excretion was observed during urinary tract infection, sepsis, and acute tubular necrosis whereas urinary beta MG increased during these events as during transplant rejection. Urinary TXB2 was found to be an early, specific, and sensitive marker of renal allograft rejection with greater reliability than beta MG excretion or clinical signs of rejection.

Adolescent↗
PubMed1984

[Treatment of renal artery stenosis following kidney transplantation].

Stenoses of the renal artery occurred in 4.6% of 415 transplanted kidneys between 1969 and 1983. Most of them were caused by traumatic intima-lesions and were localised postanastomotically. The best therapeutic procedure seems to be the transperitoneal approach with widening venous patch plasty or venous bypass. The percutaneous transluminal catheter dilatation may be successful in suitable cases.

Angioplasty, Balloon↗