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Biomedical subjects

H White

Publications and source records attributed to H White.

At least 163 records · Page 9Linked to original sources
PubMed1985

The omentum in malignant diseases.

The technique and applications of omentoplasty are reviewed from the point of view of the surgical oncologist, with particular emphasis on the use of the omentum in gastrointestinal anastomoses, covering peritoneal defects or radical intra-abdominal operations for neoplastic disease, urological complications, breast cancer, abdominal and chest wall resections, the prevention of arterial graft erosions, and the treatment of lymphoedema and chemotherapeutic burns. Complications are discussed as well as future prospects.

Abdomen↗
PubMed1985

Strain differences in susceptibility to murine respiratory mycoplasmosis in C57BL/6 and C3H/HeN mice.

Not only is murine respiratory mycoplasmosis, due to Mycoplasma pulmonis, a complication of biomedical research, it provides excellent animal models to study the development of a naturally occurring respiratory disease induced by an infectious agent. The understanding of pathogenic mechanisms of disease can be greatly facilitated by studying genetic differences in susceptibility. Five strains of mice with various H-2K haplotypes were examined for their susceptibility to murine respiratory mycoplasmosis; of these, C57BL/6 and C3H/HeN mice were chosen for additional study. There were no significant differences in the incidence of infection in either the upper or lower respiratory tract or in the severity of upper respiratory tract lesions in the two strains as determined at 14 days postinfection. In striking contrast, the C57BL/6 mice were significantly more resistant to the development of gross and microscopic lung lesions and to death due to pneumonia as shown by an almost 100-fold difference in the 50% lethal dose, 50% gross pneumonia dose, and 50% microscopic lesion dose. The most apparent differences in lung lesions between the two strains were in the severity of acute lesions of the bronchial epithelium, the amount of mixed inflammatory response in the alveoli, and the amount of lymphoid infiltrates. All were significantly more severe in C3H/HeN mice. In addition, more C3H/HeN mice developed antibody responses to M. pulmonis. The amount of antibody correlated with lesion severity in both strains.

Animals↗
PubMed1984

The molecular structures and interactions of bovine and human gamma-crystallins.

Knowledge of the three-dimensional structure of bovine gamma II-crystallin has provided the basis for building molecular models using computer graphics of two human gamma-crystallins, the sequences of which have recently been determined. The tertiary structures of these gamma-crystallins are predicted to be highly conserved. They have extensive networks of interacting charges on their surfaces, which may contribute to their thermodynamic stability and partially define the degree of water retention in the lens. The human crystallins appear to be more hydrophobic than the bovine molecule. All have arrangements of cysteine thiols which may be important as electron sinks and reserve redox potential in the normal lens but which may contribute to protein aggregation in cataract.

Amino Acid Sequence↗
PubMed1984

Multiple assessment of coping strategies used by volunteer blood donors: implications for preparatory training.

The coping strategies used by volunteer blood donors were assessed in two studies. A general trait measure and a specific process measure of coping were administered in both studies. A state measure of coping was added in the second study. The relationships among these measures and their relationships with anxiety measures and demographic variables [e.g., sex and prior donation frequency] were examined. Moderate correspondence was found among the coping indices, but the process measure was most predictive of anxiety ratings. An avoidant coping strategy appeared to be most effective in terms of managing the stress of blood donation. Implications of the results for the conceptualization and assessment of coping are noted, and suggestions are made regarding factors which may affect the preparation of patients for stressful medical or dental treatment.

Adult↗
PubMed1984

Treatment of patients with metastatic osteogenic sarcoma: a report from the Children's Cancer Study Group.

Fifty-three patients with metastatic osteogenic sarcoma were treated with vincristine, high-dose methotrexate with citrovorum factor rescue, and cisplatin. Metastases were surgically removed in most patients, either prior to chemotherapy or following initial response to therapy. Among 29 previously treated patients, responses to initial chemotherapy included two complete remissions, six partial remissions, and eight patients with stable disease. Twenty-three patients were disease-free, six for greater than 12 months. Toxicity was moderate, but usually reversible. There were two toxic deaths and one unexplained death 48 hours following a dose of cisplatin.

Adolescent↗
PubMed1983

Aminoglutethimide for the treatment of advanced postmenopausal breast cancer.

Two hundred and thirteen unselected postmenopausal women with advanced breast cancer were treated with aminoglutethimide and hydrocortisone. There were 6 complete responses (CR), 47 partial responses (PR), 25 stable disease (SD) and 3 mixed response. Overall objective response rate was 28%, and with SD 41%. Median duration of objective response was 14 months. Years after menopause, age and tumour-free interval did not affect response rates. Main side-effects were drowsiness and lethargy (33%), rash (23%) and nausea (15%). Eleven patients (5%) stopped treatment because of toxicity. Median survival from start of treatment was 28 months and was the same for CRs, PRs and SD, compared with 10 months for progressive disease (P less than 0.001). Median survival from first metastasis was 43 months for PR/CR, 40 months for SD (not significantly different) and 22 months for progressive disease (P less than 0.001). Aminoglutethimide is an effective endocrine therapy in advanced postmenopausal breast cancer, particularly for bone deposits. Disease stabilization is associated with symptomatic and survival benefit similar to CR/PR.

Adult↗
PubMed1983

Semantic congruity and expectancy in symbolic judgments.

These experiments assess the degree to which the semantic-congruity effect in comparative judgment can be explained by such expectancy effects as priming, perceptual "set," or strategies used in the task. The first experiment mixed a lexical-decision task with the comparative-judgment task and showed that neither automatic semantic priming nor deliberate preparation can account for the congruity effect. Experiments 2-4 assessed expectancy effects in a different way by presenting the instructions for comparative judgment either before or after the pair to be judged. These experiments included, among other things, a number of safeguards against artifacts in this paradigm. In these three experiments the congruity effect was obtained with both orders of stimuli and instructions, contrary to the prediction of an expectancy hypothesis. The results indicate that when stimuli are not degraded. The semantic-congruity effect depends largely on the relation between the stimuli and the instructions and only to a small degree, if at all, on expectancy.

Cues↗
PubMed1983

Experimental infectious bovine rhinotracheitis: comparison of four antigen detection methods.

The duration of detectable viral antigen in nasal secretions was studied by four methods in calves experimentally infected with infectious bovine rhinotracheitis. Virus isolation in cell culture was the most sensitive and was successful for up to 11 days after inoculation. Three direct rapid antigen detection systems (immunofluorescence, immunoperoxidase and enzyme-linked immunosorbent assay [ELISA]) were all successful during the pyrexic phase, but less useful in the later stages of the disease. Virus isolation and ELISA remained positive in strongly positive samples stored for a week at room temperature.

Animals↗