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Biomedical subjects

H White

Publications and source records attributed to H White.

At least 199 records · Page 11Linked to original sources
PubMed1978

LeVeen shunts.

Explore the source record for details and available documents.

Ascites↗
PubMed1978

Empyema as a complication of retropharyngeal and neck abscesses in children.

Empyema developing from retropharyngeal abscess is a rare complication. Two infants with clinical symptomatology and inital chest radiographic findings of pleural fluid which suggested the possibility of retrophoryngeal abscess are described. A child with submandibular and cervical abscesses is also reported; pleural fluid and mediastinal abscess developed less than 24 hours after admission. Pathological processes in the neck can spread into the chest or conversely, either by direct continuity or by dissection through the fascial planes enveloping the cervical compartments. The middle or visceral space which is in direct continuity with the mediastinum is generally the area in which cervicothoracic disease inter-relates.

Abscess↗
PubMed1978

Plastic bowing, torus and greenstick supracondylar fractures of the humerus: radiographic clues to obscure fractures of the elbow in children.

The anterior humeral line is a valuable aid in the search for supracondylar fractures in children. When it is abnormal other signs of fracture should be carefully sought. The AHL was normal in only 5.8% of the cases reviewed (4 of 68 cases). There was other evidence of fracture in each case. Comparison of the AHLs on both sides is helpful when the AHL is normal since it may disclose subtle displacement of the line on the affected side. In children younger than 2 1/2 years the AHL may pass through the anterior third of the capitellum due to the small size of the ossification center; in these patients comparison with the opposite side may also be helpful.

Child↗
PubMed1978

Mediastinitis from odontogenic and deep cervical infection. Anatomic pathways of propagation.

Potentially lethal consequences can quickly occur once the mediastinum is subjected to the ravages of an anaerobic infection. Mediastinitis from odontogenic or deep cervical infections is extremely rare in the era of antibiotic drugs. We have recently encountered five such cases, with a rapid spread of the inflammatory process into the mediastinum resulting in a number of local and systemic complications. All were caused by anaerobic bacteria. Awareness of such complications and early roentgenographic diagnosis lead to prompt surgical drainage, proper antibiotic therapy, and survival after a stormy clinical course. The anatomic pathways between the various fascial planes of the neck and mediastinum will be described.

Adolescent↗
PubMed1977

Clinical and radiographic considerations of sacrococcygeal teratomas: an analysis of 26 new cases and review of the literature.

Teratomas develop most frequently in the sacrococcygeum and are often diagnosed by simple observation. Most sacrococcygeal teratomas are benign, and evident in the newborn. Females are affected four times more often than males, but affected males are more likely to have malignant tumors. Benign teratomas are generally noninvasive, cystic, and contain calcifications. Surgery is the primary, usually curative treatment, although malignant tumors can be treated effectively only by early diagnosis and removal. Twenty-six cases of sacrococcygeal teratoma were reviewed.

Adult↗
PubMed1977

Injuries of the medial epicondylar ossification center of the humerus.

The complex nature of the ossification centers makes elbow injuries in a child or adolescent difficult to evaluate. The medial epicondylar ossification center is involved in a significant proportion. Injuries vary from simple avulsions to wide displacement with entrapment in the elbow. When entrapment occurs, it may be mistaken for the trochlear ossification center and the true nature of the injury overlooked. Radiographic findings are presented. The anteroposterior view was found to be diagnostic in minimal or marked avulsions of the medial epicondyle because of the characteristic inferior displacement. The anteroposterior view may not always be diagnostic in cases of entrapment of the medial epicondyle; the lateral view is usually diagnostic. In elbow dislocation, the presence and position of the medial epicondyle must be ascertained. Comparison and oblique views are often of value.

Adolescent↗
PubMed1977

Abdominal wound dehiscence. A 10-year survey from a district general hospital.

The incidence of abdominal wound dehiscence at a district general hospital was found to be about 1.5%. Analysis of a group of 123 patients with dehiscence in 3 separate years during a 10-year period confirmed that disruption most commonly occurs during the second postoperative week. The suture material used for primary closure appeared to have no influence on subsequent dehiscence. After resuture the recorded incidence of incisional herniation was 19% and the mortality was 24%. Patients who survived resuture remained in hospital for a prolonged period.

Abdomen↗
PubMed1976

Mechanism and specificity of succinyl-CoA:3-ketoacid coenzyme A transferase.

(a) The reactivity of substituted acetates as substrates for CoA transferase increases sharply with increasing basicity and exhibits a slope of 1.0 in a plot of either log kappacat or log (kappacat/Km) against pKa (betanuc = 1.0). This result shows that the catalyzed reaction, which involves both carboxylate activation and leaving group transfer, does not proceed through a fully concerted reaction mechanism in the rate-determining step. The result is consistent with a stepwise reaction mechanism that proceeds through an anhydride intermediate. (b) Equilibrium constants for thiol ester formation, either bound to the enzyme or free in solution, show the same dependence on the basicity of carboxylate ions (betaeq = 1.0) and are independent of acidity when expressed in terms of the carboxylic acid. Thus, the polar environment around substituents on the acyl group is the same for carboxylic acids, thiol esters, and oxygen esters. (c) The interaction of the terminal CH3CO group of acetoacetate with the active site causes a 200,000-fold increase in kappacat/Km, corresponding to a decrease in delta G++ OF 7.2 kcal/mol compared with an unsubstituted acid of the same pK. The binding energy of the coenzyme A moiety of the substrate is utilized to interact with the active site and cause a 10(4) to 10(6)-fold increase in kappacat, corresponding to a decrease in delta G++ of 6 to 9 kcal/mol, compared with fragments of the coenzyme A moiety added separatly or together. (d) The exchange of labeled coenzyme A into acyl-CoA substrates was found to be greater than or equal to 10(5) slower than substrate turnover.

Binding Sites↗
PubMed1976

Utilization of the inactivation rate of coenzyme A transferase by thiol reagents to determine properties of the enzyme-CoA intermediate.

The rate of inactivation of succinyl-CoA:3-ketoacid coenzyme A transferase by thiol reagents is increased 3 to 100 times by very low concentrations of acyl-CoA substrates. The same maximum inactivation rate is found with acetoacetyl-CoA and succinyl-CoA. The enhanced rate of inactivation is caused by the stoichiometric formation of the enzyme-CoA intermediate and an accompanying conformation change of the enzyme. The inactivation rate provides a simple assay for the amount of enzyme present as the enzyme-CoA intermediate, using only catalytic concentrations of enzyme. This technique has been utilized to measure (a) a rate constant for hydrolysis of the enzyme-CoA intermediate of 0.10 min-1 at pH 8.1; (b) a stoichiometry of two active sites per enzyme molecule; and (c) the equilibrium constants for formation of the enzyme-CoA intermediate from dilute solutions of substrates (and hence for the overall reaction) by determining the ratio of [enzyme-CoA]/[enzyme] in the presence of a series of substrate "buffers" at different ratios of [RCOO-]/[RCOSCoA]. As the total concentration of acyl-CoA and carbosylate substrates is increased, the inactivation rate is decreased. This indicates that the Michaelis complexes are protected against inactivation.

Binding Sites↗
PubMed1976

Acanthosis nigricans and wart-like lesions associated with metastatic carcinoma of the stomach.

A 63-year-old white man developed malignant acanthosis nigricans one year after a hemigastrectomy for adenocarcinoma of the stomach. Multiple "wart-like" lesions involving the dorsa of the hands, arms and trunk were also present. The malignant acanthosis nigricans in the patient appears to have paralledled the course of the metastatic gastric adenocarcinoma. Discrete verrucous lesions can occur in malignant acanthosis nigricans which histopathologically may show either squamous or basal cell hyperplasia.

Acanthosis Nigricans↗
PubMed1975

Recurrent granular corneal dystrophy.

Four full-thickness corneal buttons and tissue from one lamellar keratoplasty, derived from four patients with granular corneal dystrophy recurring in previously transplanted corneas, were studied by light and transmission electron microscopy. Fibrous tissue without vascularization was present between the epithelium and Bowman's membrane and contained deposits characteristic of granular dystrophy in both light and electron microscopy. The recurrence of dystrophy in the normal donor cornea is the result of infiltration of the grafted cornea by host invasion. The donor stroma is spared.

Adolescent↗