Urinary excretion of dextran: diagnostic test of renal allograft rejection.
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Biomedical subjects
Publications and source records attributed to H Weinberg.
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A simple method for achieving satisfactory regional anaesthesia for a wide range of hand surgery is presented. It entails separate attention to the two aims of regional anaesthesia, namely analgesia of the tourniquet and of the operative site. This study of 149 patients indicated that (a) subcutaneous ring anaesthesia produced excellent tourniquet analgesia, both in the forearm as well as the upper arm; (b) a tourniquet applied to the forearm provided excellent regional ischaemia in 98% of our cases, contrary to what has been previously accepted. The advantages of this method are its safety and simplicity even for the relatively untrained surgeon. It also obviates the need for brachial plexus blocks, intravenous regional or general anaesthesia with all their drawbacks.
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Reimplantation was attempted in 24 of 30 amputated fingers in 16 patients; 17 attempts were successful. The indications for surgery, the operative technique postoperative complications and results are discussed. It should be stressed that revival of the amputated digits does not necessarily mean functional success, and a careful evaluation of the results is needed. Organization of the reimplantation service is very important for achieving better results in this branch of surgery.
The lateral distribution of the CNV was investigated during conditions that required normal male and female subjects to vocalize simple English words in a CNV paradigm. In addition to a non-verbal or comparison condition (Tone-Clicks/Button Press), two word conditions presented stimulus words in either S1 or S2 positions (Word-Tone/Speak; Tone-Word/Speak) and a third condition required a one-word association to the stimulus words (Word-Tone/Speak Association). Monopolar scalp activity was collected from sites that included a location approximating Broca's speech area on the left hemisphere, a homologous comparison site on the right hemisphere, frontal sites (F3, F4) and the vertex (Cz). Although several subjects showed some asymmetrical activity in some of the word conditions, amplitude measures based on CNV averages indicated no consistent lateralization effects over the left hemisphere prior to word vocalizaiton. Negative pretrial shifting was suspected in those conditions in which words appeared as S1 signals.
A new method is presented for arthrodesis of small joints in the hand. In this method Kirschner wires are inserted dorsoventrally through the phalanges on either side of the joint, and the external ends bent into hooks. Longitudinal compression is achieved by connecting these hooks with rubber bands. This technique gives a solid and painless immobilization in a proper position, and the latter can be corrected easily when necessary. We arthrodesed 46 joints in 39 patients by this method in 1975 and 1976. The fusion time was 4 to 6 weeks, and the method produced a good bony arthrodesis in 42 of the 46 fingers.
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We describe a new technique to treat the mallet finger deformity. The method is both simple and efficient, and it does not require follow-up for splint or dressing adjustment. All of our 15 cases regained function without complications.
In rabbits, an experimental model of fat embolism was produced that simulates the course of events in the clinical situation. Small doses of fat-cell suspension (0.075 ml/kg of body weight), prepared by collagenase treatment of homologous adipose tissue, were injected intravenously. Concomitantly, hypovolemia was produced in two animal groups by either withdrawing 20 percent of the estimated blood volume or by application of a hind-limb ischemic tourniquet for 90 minutes. The presence of pathoanatomic characteristics typical of fat embolism was evaluated by recording lung/body weights, macroscopic appearance, and semiquantitative microscopic estimation in the lungs of edema, hemorrhage, atelectasis, intravascular coagulation, and leukocytic thrombi. Mean indices of lung/body weight were higher in all animals receiving injections of fat-cell suspension, as compared to controls. The score for microscopic generalized pulmonary damage was significantly higher in rabbits exposed to both fat-cell injections and hypovolemia than in controls or after fat-cell injections alone. It is concluded that hypovolemia enhances the development of fat embolism in rabbits subjected to small doses of fat-cell suspension.
The purpose of this study was to assess the possible role of hypovolemia as a factor in the production of impaired pulmonary function in pulmonary fat embolizaiton. Iv vivo static lung compliance was measured by inflating the lungs with known volumes of air and recording the transpulmonary pressure, monitoring intraesophageal pressure as an index of intrapleural pressure. Arterial blood was drawn from the central artery of the ear. Embolization was produced by the intravenous injection of homologous fat cells either as the sole experimental procedure or in conjunction with hypovolemic shock. Two types of shock were studied. In one, 20 percent of the blood volume was removed, producing hypovolemia associated with hemodilution, and in the other a tourniquet was applied to induce hypovolemia and hemoconcentration. The results indicate that embolization is associated with significantly greater impairment of pulmonary function if it develops on a background of shock than if it occurs in an otherwise healthy animal. These pathophysiologic findings parallel the results of a morphologic study.
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Two new techniques were used to study the distribution of the CNV recorded from the scalp of humans. One technique was for the suppression of eye movements and the elimination of them fron the average data. The other technique was for the recognition of differences in the form of CNVs recorded from different sites. The latter technique utilized an average vertex CNV as a template pattern against which CNVs from the vertex, left and right frontal, central and parietal sites were matched. The results showed that the frontal CNV was different in form from the vertex, central and parietal Cnvs and that the vertex, central and parietal CnvS were similar in form. An analysis of the amplitudes of CNVs showed that the frontal CNVs were significantly smaller than the CNVs from all other sites, that the vertex CNV was significantly larger than the parietal or central CNVs and that the central CNV was significantly larger than the parietal CNV. There were no differences in amplitude between hemispheres within Condition A responding with the right hand) or Condition B (responding with the left hand) or between Conditions A and B. The results are discussed with respect to their possible theoretical implications.
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