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Biomedical subjects

H Weill

Publications and source records attributed to H Weill.

132 records · Page 8Linked to original sources
PubMedDate not supplied

Pulmonary function in sandblasters' silicosis.

Lung function was examined in 55 patients with sandblasters' silicosis. In this type of silicosis, patients with simple nodular disease had normal function. Restrictive and obstructive impairment was present in patients with large opacities, and was more marked in patients with radiographic evidence of contraction or cavitation. In the last group, striking average annual declines in ventilatory function occurred. Compared to patients with classical silicosis, these patients were younger and had intense, short exposures to free crystalline silica. The pattern of functional abnormalities suggested that restriction of lung volumes is a fundamental abnormality in this form of silicosis.

Adult↗
PubMedDate not supplied

Disaster at Bhopal: the accident, early findings and respiratory health outlook in those injured.

In December, 1984, in Bhopal, India, a massive leak of methyl isocyanate (MIC) resulted from operational and equipment malfunctions in a pesticide plant. Many thousands of residents of the city, most in proximity to the plant, suffered sublethal and lethal respiratory injuries, the expected consequences of high-level exposure to this type of potent irritant chemical vapour. Animal toxicologic information was limited prior to the accident, but has since confirmed that the lung is the major target of these lethal injuries, invariably with pulmonary oedema. Early concerns regarding acute cyanide intoxication were not supported by subsequent scientific inquiry. Superficial corneal erosions did not result in permanent eye injury. The primary medical (and, presumably, legal) issue which is unresolved, and perhaps unresolvable, is the incidence and determinants of long-term respiratory injury in the survivors. Available evidence, which is limited, suggests that chronic damage, when present, is, or resembles, fibrosing bronchiolitis obliterans, the expected consequence when permanent injury results from acute, high-level irritant gas exposure. Definition of the follow-up population is uncertain, and exposure information is lacking. Dose-response relationships are not likely to emerge from follow-up studies.

Accidents, Occupational↗