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Biomedical subjects

H Wehner

Publications and source records attributed to H Wehner.

At least 55 records · Page 3Linked to original sources
PubMed1976

The different forms of glomerulonephritis morphological and clinical aspects, analyzed in 2500 patients.

Comparative morphological and clinical studies of 2,500 patients suffering from glomerulonephritis, enabled us to divide the different forms of diffuse glomerulonephritis into 3 distinct groups and to separate these groups from the focal glomerulonephritides. The different forms of diffuse glomerulonephritis in group I are: 1. endocapillary (acute) glomeruloenphritis (of the post-streptococcal type), 2. mesangioproliferative glomerulonephritis, 3. mesangioproliferative glomerulonephritis with focal crescents, 4. mesangioproliferative glomerulonephritis with focal scarring, 5. minimal proliferating intercapillary glomerulonephritis without nephrotic syndrome. It is emphasised that these forms can transform into one another, that they seldom occur with nephrotic syndrome, and with varying frequency with hypertension. Group II consists of: 1. minimal proliferating intercapillary glomerulonephritis with nephrotic syndrome, 2. focal sclerosing glomerulonephritis, 3. perimembranous glomerulonephritis, 4. membranoproliferative glomerulonephritis, 5. lobular glomerulonephritis. It is stressed that these glomerulonephritis forms usually do not develop out of group I type glomerulonephritis forms, and that in this group a nephrotic syndrome is the most prominent clinical syndrome. In the third group are 1. mesangioproliferative glomerulonephritis with diffuse crescents, 2. necrotising glomerulonephritis. It is shown that this form of glomerulonephritis does not usually develop from either group I of II forms. The fourth group of focal glomerulonephritis is uncommon. This disease is characterized by a necrotising and proliferative inflammatory lesion found segmentally and focally in the glomeruli. Most of the other glomeruli appearing normal. It is emphasised that in the literature the diagnosis focal glomerulonephritis is made far too often. This is because glomeruli in which the inflammatory process in a few lobules is of varying prominence, are included in the focal glomerulonephritis group. The classification of the different forms of glomerulonephritis into 3 groups here described, is thought of as a basic classification. It is compared with Ellis' classification (1942), with which it has much in common.

Basement Membrane↗
PubMed1976

The influence of insulin and insulin antibodies on the glomerular structure.

Guinea pigs and rabbits were treated with heterologous insulin preparations of different purity for 3 months without Freund's adjuvant. The insulin binding capacity of the serum, as well as the light and electron microscopic structure of the glomeruli were studied and the glomerular structure was analyzed with quantitative methods. By a longer treatment with heterologous commercial insulin preparations a proliferation of mesangial cells and a thickening of the mesangium matrix were showed. Furthermore, hump-like basement membrane protuberances were found in the glomerular capillary wall. Their frequency increased when more insulin antibodies were formed. Rabbits treated with MC insulin showed no significant antibody formation and no significant changes in the glomerular structure. Otherwise, in animals treated with the impurities of the insulin preparations (a+b component) a marked increase in the basement membrane protuberances was demonstrable accompanied by a higher antibody titer. An increase in the mesangial cell density as well as an increase in the mesangial volume were also present. The results confirm the findings that a contaminating protein in crystalline insulin to be responsible for the antigenic properties.

Animals↗
PubMed1975

[Renal changes by treatment with azatioprine (author's transl)].

Results of three months' treatment of 10 glomerulonephritic, 10 normal guinea pigs and of 10 normal rats with imurek (20 mg/kg/day) were as follows: 1. The morphological picture of glomerulonephritis was demonstrable even three months after treatment with imurek. 2. Predominant glomerular changes were demonstrated in both of guinea pigs and rats after treatment with imurek. These changes consisted of mesangial activation, focal glomerular necrosis and deposits of an amorphous clumped material in the mesangium. 3. In some animals, streptococci and staphylococci could be cultivated from the blood of the vena renalis and from the renal surface. The results of the present study indicates that treatment of glomerulonephritis with immunosuppressiva is not always effective. It is probable that morphological deteriorations may be caused by a direct effect of the immunosuppressiva on the renal structure.

Animals↗
PubMed1975

Early glomerular changes in streptozotocin diabetes of the guinea pig.

This work was to study--using morphometric methods--whether glomerular alterations are demonstrable in the guinea pig kidney even in streptozotocin diabetes of only short duration. In 25, 50, 100 and 150-days diabetes was investigated the blood sugar, the glucose tolerance test, histological and morphometric studies. Storage of glycogen in the kidney was to be found in numerous treated animals whereby it was evident that the cells of the macula densa showed no storage. The morphometric studies performed under blind conditions have shown that with a duration of diabetes of 50 and 100 days the number of cells in the mesangium is increased and that an increase of the mesangial matrix is demonstrable. Hence the mesangium is in the foreground of the initial alterations in diabetes mellitus.

Animals↗
PubMed1975

Histometrical glomerular studies in minimal proliferative intercapillary glomerulonephritis (minimal changes without nephrotic syndrome) with different clinical symptomatology.

Histometrical glomerular studies were carried out in minimal proliferative intercapillary glomerulonephritis (minimal changes without nephrotic syndrome) with different clinical symptomatology. Results of morphometric examinations of renal corpuscles of 58 cases of minimal proliferative ntercapillary glomerulonephritis (MPI-GN) without nephrotic syndrome were compared with those of normal and mesangiosproliferative glomerulonephritis cases and showed that MPI-GN without nephrotic syndrome is accompanied by proliferation of the glomerular cells. The cell density in the glomeruli is increased by 47% compared with the norm. Different clinical symptoms (proteinuria, haematuria, haematuria and proteinuria) have no different morphometrical correlate. A differentiation of this disease from mesangio-proliferative glomerulonephritis seems justified.

Diagnosis, Differential↗