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Biomedical subjects

H Weber

Publications and source records attributed to H Weber.

At least 505 records · Page 28Linked to original sources
PubMed1980

Fontan procedure and surgical modification in tricuspid atresia.

Nineteen patients with tricuspid atresia and reduced lung perfusion (valvular-and/or subvalvular pulmonary stenosis, transposition of the great arteries and/or single atrium) were operated in the period 1975--1979. The surgical procedures employed varied according to the additional cardiac defects. The age of the patients was between 2 and 18 years. Eleven children received a contuit with a Hancock valve, 8 children a valveless conduit. In 9 patients it was possible to connect the conduit to the right ventricle using the pumping action of the right ventricle with an anatomically intact pulmonary valve. Six patients died (4 early deaths, 2 late deaths, early mortality rate 21%). In this study, the postoperative courses, which were complicated in several cases, are related to the hemodynamical findings. Thirteen children were examined between 1 and 38 months following the operation. Cardiac catheterization was performed in 10 patients. Of the 13, 10 had fully saturated arterial blood. A remnant atrial defect was demonstrated in one child, and 2 displayed intrapulmonary shunts attendant to Glenn anastomoses which had been in place for 10 to 12 years. Among the patients the right atrial pressure ranged from 10 to 20 mmHg with a mean value of 14.5 +/- 0.9 mmHg. An increase in size of the right ventricle was demonstrated angiographically in the case of 2 patients who had valve-bearing conduits to the right ventricle.

Adolescent↗
PubMed1980

[Pre-eclampsia and placental hormones (author's transl)].

Human placental lactogen (HPL) and beta 1-SP-1, a placental glycoprotein specific for pregnancy, were determined in 177 pregnant women with pre-eclampsia of varying severity. The serum levels of both hormones decrease during pregnancy in concordance to the severity of pre-eclampsia. In women with severe pre-eclampsia more than 50% showed extreme decreases of the serum concentrations of both hormones. Because of the simple methodology of the test, rapid availability of the results and a lower cost, the determination of the beta-1-SP-1 is perferable to the determination of HPL.

Female↗
PubMed1980

[Electrophoretically applied opaque layers].

The objective of this investigation was to find out what the composition of an electrophoretically applied opaque layer looks like. Metal samples were coated manually and electrophoretically with opaque. Density measurements as well as lightmicrographs taken from these specimen showed that the opacifying agents of dental opaques play a very important role within the electrophoretical technique. A study of new application procedures showed that not all opaque porcelains can be processed electrophoretically.

Densitometry↗
PubMed1980

The in vitro uptake of 14C-praziquantel by cestodes, trematodes, and a nematode.

14C-praziquantel was rapidly taken up by Schistosoma mansoni, Fasciola hepatica, Hymenolepis nana, and isolated strobilocerci of Taenia taeniaeformis. Schistosoma mansoni lost praziquantel rapidly to drug-free medium. Chromatography of extracts prepared after incubation of S. mansoni and H. nana yielded no indication that praziquantel was metabolized. Autoradiography revealed a uniform distribution of praziquantel throughout the tissues of S. mansoni and H. nana. Uptake was considerably slower in the nematode Heterakis spumosa and apparently via the oral route.

Animals↗
PubMed1980

[Reconstruction of underdeveloped right ventricle and tricuspid hypoplasia (author's transl)].

Total correction of underdeveloped right ventricle related to tricuspid hypoplasia has been performed in 6 patients at the department of thoracic and cardiovascular surgery University Göttingen. In 5 patients reconstruction of a four-chamber-four-valved heart could be accomplished. 1 patient with a poor result after Fontan's operation, performed one year previously, showed a significant growth in size of the hypoplastic right ventricle in the postoperative angiogram, but died 14 hours after reoperation. Prior to corrective surgery, 4 patients required 1 or 2 palliative procedures: 3 Glenn- and 2 Blalock-Taussig operations and a pulmonary valvulotomy in 1 patient. A Hancock-valved conduit was inserted between the right atrium and the hypoplastic right ventricle as an inlet of this chamber after closure of the ASD and VSD in 4 patients. The conduits are bypassing the hypoplastic tricuspid valve orifices closed during corrective surgery. In the remainder 2 patients with moderate tricuspid and right ventricle hypoplasia, closure of the ASD was performed only. Anomalous muscle bundles and fibrous tissue inside the right ventricular cavity were resected surgically, safely. 4 to 12 months after corrective surgery the 5 survivors were investigated by cardiac catheterization. In the 3 patients operated with a valved conduit there was a moderate growth in size of the hypoplastic right ventricle, the right atrial pressure was elevated and ranged from p = 14 to 16 mm Hg. There was a slight right atrial-right ventricular gradient of 4 mm Hg across the valved conduit. The 2 patients with closure of the ASD and VSD only had a nearly normal-sized right ventricle and a right atrial pressure of p = 10 mm Hg or less at the postoperative right ventricle and a right atrial pressure of p = 10 mm Hg or less at the postoperative investigation. All of them were acyanotic and had an improved or normal exercise tolerance. We concluded that reconstruction of an underdeveloped right ventricle in well-selected cases will yield more physiological benefits than do current surgical procedures, in which a conduit is interposed between the right atrium and the main pulmonary artery.

Adolescent↗
PubMed1980

[Diagnosis and treatment of arrhythmias after Mustard-Brom operation for transposition of the great arteries (author's transl)].

Arrhythmias after Mustard's operation for transposition of the great arteries were studied in 96 patients operated upon between June 1965 and July 1979. All patients had sinus rhythm consistently before the operation. Surgical modifications aimed at preserving the sinoatrial (S-A) node have reduced but not avoided arrhythmias. During the follow-up period in 54 patients (56.25%) different arrhythmias were observed. Sick-sinus syndrome was detected as the most frequent rhythm disturbance. The highest incidence of arrhythmias was in the first 6 weeks after the operation. However, life-threatening arrhythmias and sudden death occurred even years after Mustard's operation. Overall, there were 31 deaths (32.3%) in which severe arrhythmias were involved. In 6 patients sudden death occurred 4 weeks to 3 years postoperatively, attributable to rhythm disturbances. In one patient who died from sick-sinus syndrome, the histologic features of the S-A nodal area were examined. The S-A node was replaced by dense connective tissue. In another patient who had recently undergone Mustard's operation, S-A nodal tissue was identified, but fresh hemorrhage was seen in and about the node. Different antiarrhythmic drugs were employed in the treatment of arrhythmias observed after Mustard's operation. In 34 patients (36.4%) temporary pacing was necessary. In case of failure of antiarrhythmic drugs, permanent pacing is the therapy of choice.

Anti-Arrhythmia Agents↗
PubMed1980

[The oxygen saturation of blood in the venae cavae, right-heart chambers, and pulmonary artery, comparison of formulae to estimate mixed venous blood in healthy infants and children (author's transl)].

For the localization and quantification of arterio-venous shunts of the heart and great vessels, accurate definition of the degree of oxygen saturation of venous blood in the venae cavae, right heart and pulmonary artery is essential. Hitherto only a few investigations in a small number of healthy subjects were published. Extensive investigations to define normal mixed venous blood in infants and children are unknown. This presentation is an analysis of the data on oxygen saturation of venous blood in 305 healthy children or patients with insignificant cardiac defects. Shunt lesions were excluded. A comparison of several formulae used to estimate the oxygen saturation of mixed venous blood from caval samples has been made. The sources of error in the estimation of mixed venous blood and the implications for the calculation of the shunt-volume are investigated in 122 patients without cardiac defects. The mean oxygen saturation from the right ventricle most nearly approached the mean oxygen saturation of the pulmonary artery whereas high inferior vena cava saturations correlated poorly with mixed venous blood. Superior vena cava, the mean oxygen saturation of the right atrium and the formula 3 x SVC + HIVC divided by 4 = MVB (where SVC is superior vena cava, HIVC is high inferior vena cava MVB is and mixed venous blood) gave a satisfactory regression and have nearly the same value for prediction of mixed venous blood.

Adolescent↗