Biomedical subjects

H Warnke

Publications and source records attributed to H Warnke.

At least 55 records · Page 3Linked to original sources

PubMed1978

[Coronary heart disease; surgical aspects (author's transl)].

Aspects of indication, of the surgical technique as well as long-term results are discussed on the basis of own experiences in 279 coronary artery operations. Patients suffering from unstable angina pectoris should be operated on as soon as possible. In cases with stable angina pectoris due to a triple vessel disease the long-term results are better with surgery than without.

Angina Pectoris↗

PubMed1978

[Electronmicroscopic changes in the myocardium of children with cyanotic heart diseases].

In 7 children with Fallot's tetralogy ultrastructural quantitative and qualitative investigations on the heart muscle were carried out. Bizarre nuclei and slightly increased volume of mitochondrial part indicated hypertrophy. The amount of mitochondria was 35.07 per cent. The content of glycogen is relatively high. The lipofuscin bodies, mainly originating from mitochondria, amount to 1.43 per cent. No essential damage is observed. From the ultrastructural findings can be concluded that surgery may be done without suspicion as to cardiac cell morphology.

Cell Nucleus↗

PubMed1978

[Experimental studies on surgical therapy of acute infarct].

The authors examined the effects of reperfusion after temporary ischemia in 50 dogs. The morphologic alterations were documented by methods of electron microscopy, fluorescence microscopy, and histochemistry. Lactate and activity of glycogen phosphorylase were assessed. According to the results, the optimal ischemia interval is 30 to 60 minutes for rational application of reperfusion, while it is just possible after 120 minutes. After a 4-hours-period of ischemia reperfusion increase morphologic damage of myocardium and impairment of myocardial metabolism. Prolonged reperfusion of 7 days resulted in a reduced extent of infarction compared with controls. In non-ischemic myocardium the morphologic and metabolic alterations were less expressed. The effects of "no-reflow"-phenomenon and conclusions for clinical practice are discussed.

Animals↗

PubMed1978

[Reperfusion of the myocardium after acute ischemic lesion].

In a complex experimental study on 52 dogs the myocardium was examined after ischemia and reperfusion of various duration. Morphologic, metabolic, and functional findings proved that a short-term reperfusion after coronary occlusion for more than 2 hours has disadvantageous effects on the regression of ischemic lesions. During the early period (up to 3 days) this is caused by the "no-reflow" phenomenon. Combined qualitative and quantitative findings are required for correct appraisal of the ultrastructural alterations after reperfusion. In acute coronary occlusion, early revascularization after passing the crucial initial phase is advantageous, because the extent of myocardia necrosis is decreased by the prolonged reperfusion, thus leaving a larger myocardiac reserve in case of re-infarction. Clinical conclusions are drawn.

Animals↗

PubMed1976