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H Wajcman

Publications and source records attributed to H Wajcman.

207 records · Page 12Linked to original sources
PubMedDate not supplied

[Good practices for the study of hemoglobin].

Hemoglobinopathies have become a significant national health problem in France. The biologists have a pivotal role in the genetic diagnoses. Although sickle cell disease (SCD) is the most frequent abnormality found: not less than 200 new cases are observed each year at birth, many other globin gene variations are found in the various ethnic groups. Since 1995 a neonatal sickle cell screening program has been established for at risk newborns. This programme is supported by the "Association française de dépistage et prévention des handicaps de l'enfant" (AFDPHE). The characterization of hemoglobin genetic variations requires a comprehensive set of laboratory techniques for which we specify here main clinical and technical recommendations.

Blood Chemical Analysis↗
PubMedDate not supplied

[Hemoglobinopathies in West-African immigrant workers in France (author's transl)].

In this paper are brought the results obtained in two Parisian hospitals during a survey of abnormal hemoglobins in 540 immigrant workers coming from Africa, mostly from Mali, Mauritania and Senegal. All the subjects investigated were male and between 20 and 40 years old. The studies were performed following internationally standardized technics. The most frequent abnormalities were: Hb S found in 16.3%, Hb C (6.6%), alpha-thalassemia trait (3.1%) and beta-thalassemia trait (3.1%). Some rare abnormalities were also found: delta-chain variants, hereditary persistance of foetal hemoglobin, Hb Hope and Hb Grady. This work emphasizes the high frequency of the different hemoglobin disorders in this population. The easy diagnostic of electrophoretically detectable variants is compared to the more complex situation of thalassemia leading probably to an under estimation of the percentage.

Adult↗
PubMedDate not supplied

[Measure of glycosylated hemoglobin A1c: its value in the control of juvenile insulin-dependent diabetes (author's transl)].

HbA1c percentage was determined in 82 insulin-dependent juvenile diabetic patients. The concentration of HbA1c reflects the level of chronic hyperglycaemia during the preceding 4 to 8 weeks and appears to correlate closely with the commonly used methods for monitoring diabetic control. HbA1c measurement provides a reliable and objective test for periodic assessment of insulin-dependent juvenile diabetes. It may serve as a valuable tool for determining the level of metabolic control in each patient and measuring the effectiveness of various therapeutic regimens.

Adolescent↗