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Biomedical subjects

H Wada

Publications and source records attributed to H Wada.

At least 883 records · Page 49Linked to original sources
PubMed1988

Plasma levels and renal clearance of two isomers of dopamine sulfate in patients with essential hypertension.

Two isomers of dopamine sulfate, dopamine 3-O-sulfate(3-O-S) and dopamine 4-O-sulfate(4-O-S), in the plasma and urine of patients with essential hypertension and normotensive controls were measured by HPLC-fluorometry. The plasma level of 3-O-S was significantly higher in patients with essential hypertension than in normotensive controls (20.9 +/- 2.2 pmol/ml and 16.3 +/- 1.4 pmol/ml respectively, p less than 0.05) and the plasma levels of 4-O-S were slightly increased in hypertensive patients. The plasma level of 3-O-S was correlated with the serum level of creatinine in both normotensives and hypertensives. In hypertensives, the plasma level of 3-O-S was also correlated with that of noradrenaline. However the creatinine clearances were similar in the two groups, the urinary clearance of 3-O-S was slightly lower in patients with essential hypertension than in normotensive controls. These data indicate that the plasma level of 3-O-S is elevated in essential hypertension because of the abnormality in dopaminergic metabolism and renal disturbance in its excretion.

Creatinine↗
PubMed1988

Parietal cephalocele: clinical importance of its atretic form and associated malformations.

In this study of atretic cephaloceles, the authors have considered the pedunculated or sessile type of cephalocele and also small nonpedunculated scalp defects developing in the vertex midline. Parietal cephaloceles were found in 15 infants (10 boys and five girls), and accounted for 37.5% of all cephaloceles. They consisted of four encephaloceles, six meningoceles, and five atretic cephaloceles. The clinical and morphological characteristics of parietal cephaloceles were investigated and compared with those arising at other locations. Parietal cephaloceles carried a much less favorable prognosis than those in the occipital region, regardless of the type of cephalocele; they were associated with cerebral malformations more frequently and were more severe than occipital cephaloceles. Grave congenital anomalies were found in 87% of patients with parietal cephalocele, and only two patients (neither of whom had any other malformation) attained normal development. Brain malformations were closely related to the site from which the cephalocele issued, and dorsal cyst malformation was found in eight patients with parietal cephalocele. Two types of atretic cephaloceles were found, each in a different location. The first type was an alopecic lesion occurring in the parietal midline; all five patients with this type had dorsal cyst malformations and none developed normally. The second type was a nodular lesion developing at the occipital midline, not associated with cerebral anomalies; all five patients with this type showed normal development. The pathogenesis of atretic cephaloceles and their associated intracranial malformations are discussed.

Alopecia↗
PubMed1988

[Effectiveness of preoperative transcatheter arterial embolization for improved survival rates in patients with hepatocellular carcinomas (sandwich therapy using ethiodized oil, cisplatin and gelatin sponge].

The effect of hepatic transcatheter arterial embolization (TAE) therapy was evaluated in 153 patients with hepatocellular carcinomas who underwent radical hepatectomy. They were divided into 3 groups. Group A (n = 56) received preoperative TAE using ethiodized oil, cisplatin and gelatin sponge (sandwich therapy). Group B (n = 29) received preoperative TAE using adriamycin + gelatin sponge, ethiodized oil + adriamycin + gelatin sponge or adriamycin + degradable starch microsphere. Group C (n = 68) did not receive TAE preoperatively. The 3-year disease-free survival rates in Group A, B, and C were 56%, 34% and 32%, respectively. The rate was significantly higher in Group A than Group C (p less than 0.05). The 1-year disease-free survival rates after partial hepatectomy were 89% in Group A (n = 22), 53% in Group B (n = 15) and 67% in Group C (n = 22). The 3-year survival rate of these patients in Group A was significantly higher (95%), compared to Group C (70%) (p less than 0.05). Preoperative TAE using ethiodized oil, cisplatin and gelatin sponge (sandwich therapy) was considered a useful therapy for improvement of disease-free survival rates or survival rates after hepatectomy in patients with hepatocellular carcinomas.

Aged↗
PubMed1988

[Recurrence of AVM after disappearing on postoperative angiography--report of two cases].

We reported two cases of recurrent arteriovenous malformation (AVM), which had been operated on before and these AVMs disappeared on postoperative angiography. The first case was a 13-year-old boy who had suffered from intracerebral hematoma at the age of nine years. The first angiography showed AVM located in the left central region, fed by peripheral branches of the anterior and middle cerebral arteries. Sixteen days after the onset, removal of the AVM was carried out. Postoperative course was uneventful and angiography showed that the AVM had disappeared. However, 4 years later, follow-up digital subtraction angiography showed that the AVM had reappeared in the operated region. Extirpation of the recurrent AVM was repeated. The second case was a 28-year-old woman who had presented intracerebral hematoma at the age of 23 years. Angiography revealed AVM located in the right posterotemporal region, fed by a temporal branch of the middle cerebral artery. Removal of the AVM was carried out one month after the onset. Postoperative neurological status was good and angiography showed no residual AVM. Five years later, enhanced CT scan demonstrated a linear enhanced area in the operated region. This led us to suspect recurrence of the AVM. Conventional angiography presented reappearance of the AVM, and reoperation was performed. Reported cases of AVM, which recurred after disappearing on postoperative angiography, were very rare. Small abnormal vascular channels located in the surrounding area of the main nidus may be left after the initial operation, and they may have grown to nidus some years later.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1988

[Stromal sarcoma of the breast following augmentation mammoplasty--a case report].

A case of a stromal sarcoma of the breast that developed after augmentation mammoplasty is presented. A 55-year-old woman, who had received mammoplasty twenty years earlier, was referred to our hospital due to a mass in her left breast. A diagnosis of myxoid sarcoma was determined by an incisional biopsy and a radical mastectomy was performed. A pathological specimen, however, revealed the mass to be a stromal sarcoma because of its metaplastic heterogeneous elements, such as bone, cartilage, and muscle. We also present previous cases, and discuss the matter of diagnosis and therapy.

Antineoplastic Combined Chemotherapy Protocols↗