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Biomedical subjects

H Wacha

Publications and source records attributed to H Wacha.

At least 37 records · Page 2Linked to original sources
PubMed1983

[Accidental finding: the small, differentiated thyroid carcinoma. Report of 46 thyroid carcinomas of up to 15 mm diameter].

Review of 190 cases of thyroid carcinoma between 1974 and 1981 showed an increasing rate of small papillary carcinoma. The study included 46 tumors which did not exceed 15 mm in diameter. Most of these lesions (3/4) were discovered incidentally at thyroid operations of various types. In spite of the early stage of carcinoma 6 tumors were already associated with cervical nodal metastasis, cases showed multiple lesions within the thyroid gland, homolateral and bilateral. With respect to these cases total thyroidectomy and subsequent radium therapy are generally suggested.

Adolescent↗
PubMed1981

[Is surgical treatment of small cell bronchial carcinoma still indicated?].

Based on own results, general negation of operation in small cell carcinoma of the lung does not appear warranted. Surgical treatment is indicated when a non-metastasizing tumour is present. Small cell bronchial carcinoma operated in tumour stage I has a clearly better prognosis than a carcinoma of the same stage treated by chemo- or radiotherapy. A certain response of these carcinomas to cytostatic or radiotherapy has not been established. Should tumour metastases be demonstrable, i.e. lymph node metastases in the mediastinum or distant metastases, as is the case in the majority of these rapidly metastasizing carcinomas, chemo- or radiotherapy has been shown to be superior to operative treatment.

Aged↗
PubMed1981

[Drug therapy in surgical biliary diseases. A microbiological and animal experiment study].

In this study type and occurrence of microorganisms in gallbladder and choledochal bile are compared to results of other authors. The value of antibiotic therapy in acute cystic duct obstruction in a clinical study and in animal experiments are discussed. Efficacy of different antibiotic substances (mezlocillin, cefazolin, cefotaxim, rolitetracyclin and aminoglycosides) are measured by means of the reduction in colony count in T-tube bile. Antibiotic effect was least when tetracyclines and aminoglycosides were given. Beta-lactam antibiotics caused marked reduction and even elimination of bacteria in choledochal bile. Antibiotic therapy for the treatment of bacterial infection of the bile is reasonable only after decompression of the biliary tract in the presence of obstructive jaundice. In case of cystic duct obstruction antibiotic therapy is uncertain.

Acute Disease↗
PubMed1981

[Lung resections in bronchial carcinoma of patients older than 70 years (author's transl)].

In a retrospective study (1969--1979) of 530 resections performed because of bronchial carcinoma, there were 70 patients older than 70 years (13.2%). Two-thirds of their resections were carried out on T 1--2 N0M0 and one-third on T 1--2-N1M0. For 22 central and 48 peripheral carcinomas, 25 pneumonectomies, 40 lobectomies, and 5 bilobectomies were performed. The mortality was 14.2% (lung embolism, pneumonia, apoplexia, and one insufficiency of the bronchial resection stump). Postoperative complications were atelectasis (28.5%), pneumonia (4%), lung embolism (6%), and two pleura empyemas. Of the patients operated on from 1976 to 1978, 40% (T1N0M0) and 30% (T2N0M0) and 30% (T2N0M0) are alive after 2.5 years.

Adenocarcinoma↗
PubMed1980

[Value of sputum cytology in preoperative diagnosis of bronchial carcinoma].

Of 492 in patients with primary lung cancer, pathological proof of diagnosis after thoracotomy was obtained by sputum cytology in 53,87%. Better results were obtained in patients over the age of 70 years and even in peripheral lung tumors. The results were analyzed according to tumor size, localization and malignant cell type. The prognosis of patients with positive and negative cytological specimens are compared.

Adult↗
PubMed1980

[Peritonitis after perforation of the gallbladder].

The high risk of peritonitis following a perforation of the gall bladder is discussed in a short review of the literature. In 15 years 9084 operations of the bile ducts were performed at Nord-West-Hospital, Franfurt/M., among these were 36 cases of free gall bladder perforation. Our experiences with abdominal drainage only, without perfusion of the abdomen following cholecystectomy and revision of the bile ducts with simultaneous systemic appliance of antibiotics are reported.

Adult↗
PubMed1979

[Pathogen elimination after surgical interventions on common bile duct (author's transl)].

Of 130 bile samples from the choledochus, 64% were positive for bacteria. Different antibiotics were administered according to the susceptibility tests. Colony counts were monitored daily. Beta-lactam antibiotics lead to a more rapid pathogen clearance than the tetracyclines. Antibiotic therapy is discussed especially in older patients and in patients with recurrent interventions on common bile duct. Bile cultures were positive in most of these patients.

Adult↗
PubMed1979

[What position does primary scar carcinoma of the lung take in surgical treatment of lung cancer? (author's transl)].

The results of surgical treatment of 295 resected peripheral carcinomas of the lung were analysed by tumor staging and histology. 89 cases of scar cancer of the lung have been compared to 206 peripheral cancers. The overall 5-year survival rate was far less in the peripheral lung cancer group (24%). Best prognosis had patients with tumors without lymph node metastasis or adenocarcinoma in the scar (39--45%). These tumors tend to be slowly progressive and metastasize late. When early characteristic signs can be seen on x-ray examination, lung scars should be followed carefully.

Adenocarcinoma↗
PubMed1978

[Prognosis of thyroid carcinoma (author's transl)].

Out of more than 5200 struma resections 2.2% were treated because of thyroid carcinoma. Over a 12 year' period records of 117 patients were analysed. Treatment consisted in radical thyroidectomy, radioactive iodine or radiation therapy and hormone-substitution. Differentiated carcinomas were observed more frequently, primarily extended disease decreased. The mean 5 year survival rate of differentiated tumours was 90%. Changing patterns in thyroid carcinoma, consequent postoperative care and modern radiotherapy after radical thyroidectomy without routine neck-dissection had a favourable effect on these results.

Adult↗
PubMed1978

[Antibiotic concentrations of the gallbladder following cystic duct stenosis. Clinical studies and animal experiments].

Serum and bile kinetics are measured after experimental cystic duct ligation in 24 rabbits and after acute stone obstruction in 24 clinical cases. Tissue, bile, and serum levels are compared. The results clearly demonstrate that pharmacologic data alone do not give sufficient indications for antibiotic therapy in biliary tract infection. Expected pathologic bacteria and their actual resistance are considered to be of great importance in the indication of antibiotic therapy.

Ampicillin↗
PubMed1977

[Pancoast's tumor. Symptoms, diagnosis and therapy].

Pancoast-tumor is a rare form of malignant tumor in the superior pulmonary sulcus. In our clinic out of 910 operated bronchial carcinomas 18 were Pancoast-tumors. The clinical findings with tumor of the apical lobe of the lung, shoulder-arm pain, Horner syndrome, rib destruction as well as neurological findings are discussed. The proper treatment consists of radical resection of the affected lobe, cranial thoracic wall and affected nerve tissue. The prognosis depends on the extension and lymph node metastases. Only early diagnosis, radical tumor-resection and postoperative radiation can improve prognosis and survival time.

Humans↗
PubMed1977

[Chemodectoma in the carotid triangle region].

The only treatment of the extensive and infiltrative carotid body tumors is radical resection. Exact preoperative diagnosis in unknown tumors of the neck avoid hazardous complications during operative resection. This report contains diagnosis and definition of these rare tumors. Various operative procedures of tumor-resection are discussed. Carotid angiographies and operative photographs from three cases demonstrate the extent and close relation of the carotid artery.

Aged↗
PubMed1976

[Current resistence situation in a surgical and urological department].

Spectrum and sensitivity of bacteria were studied at the Surgical (534 positive wound smears) and the Urological Clinics (7879 urine specimens). Krankenhaus Nordwest, Frankfurt/M., during the period of 1969-1971 and in 1973. The most common organisms identified in wound smears were E. coli, followed by Staph. areus, Aerobacter and Proteus species. E. coli were also predominant in urine, but followed by Enterococci, Proteus and Pseudomonas. E. coli, Proteus species and especially Pseudomonas increased in number whereas Enterococci decreased. There was no pronounced increase in resistance to 9 current antibiotics as well as to chemotherapeutics during the observation period which was particularly striking in the case of Ampicillin used on a large scale. The results of our study support the presently employed therapeutic method using bactericidal antibiotics of the penicillin group in strict indications.

Anti-Bacterial Agents↗