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Biomedical subjects

H W Springorum

Publications and source records attributed to H W Springorum.

At least 19 recordsLinked to original sources

[Conservative therapy of activated gonarthrosis. Double-blind study of proglumetacine and piroxicam].

In a randomized double-blind clinical investigation, the efficacy and safety of proglumetacin 450 mg/day (150 mg in the morning, 300 mg in the evening) were compared to those of piroxicam 20 mg/day (placebo in the morning, 20 mg in the evening), in 50 patients with activated gonarthrosis. After decoding it was found that 25 patients had been treated with proglumetacin and 25 with piroxicam. Joint troubles, knee circumference, function tests were recorded at time 0 and after 3, 7, 14 and 21 days; on the same days an overall doctor's rating of efficacy was also given. The rating of efficacy was "good" in 70% of patients in the proglumetacin group compared to 60% for piroxicam. The efficacy of the two medicaments was not significantly different. The patients treated with proglumetacin did not report any adverse reactions. Conversely, 5 patients of the piroxicam group dropped out: 1 for epigastric pain, 1 for vomiting and epigastric pain, 1 for an increase of severity of knee pain, 1 for an allergic reaction, 1 for an exanthema. The difference in drop-out rate is statistically significant. A further patient complained of gastrointestinal upsets, but continued on the treatment. Hematology and laboratory parameters were not affected by the treatments. It is concluded that in activated gonarthrosis proglumetacin has an efficacy comparable to that of piroxicam, but is significantly safer for the patients.

Anti-Inflammatory Agents↗

Contribution to stress X-ray visualization of the fibular ligaments.

To determine the extension of a lesion of the fibular ligament with customary techniques is a highly subjective matter, since it underlies personal evaluation criteria. These criteria determine the indication for surgery. Socalled fixation devices are now made available, to avoid a wide margin of errors and to provide a means of attaining standardized and reproducable findings, which facilitate clinical diagnosis. We examined the Scheuba-fixation device in terms of its diagnostic value. In routine application in the clinic the device has proven to be useful, helping to decide on the proper treatment, especially in borderline cases.

Fibula↗

[The scintigraphic diagnosis of pseudo-arthroses following Harrington's spondylodesis (author's transl)].

The development of pseudo-arthroses is the most common complication following operative treatment of severe scoliosis. Early recognition of this event is important to prevent recurrence of the curvature. The diagnosis is not possible by radiological examination of the rigid spine. Routine reexploration implies a second operation, which is unnecessary in the majority of patients with stable fusion. In an attempt to develop a non-invasive method for the diagnosis of pseudo-arthroses, bone scintigrams were carried out in 29 patients with idiopathic scoliosis twelve months after a Harrington's spondylodesis. In 24 patients (82.8%) a definite conclusion could be drawn, either of stable fusion (65.5%) or pseudo-arthrosis formation (17.3%). No pseudo-arthroses were missed by scintigraphy. These results indicate that bone scintigraphy plays an important role in the post-operative care after Harrington's spondylodesis.

Adolescent↗

[Contorsionists and athlete at competitive sports events - acquired hypermobility (author's transl)].

The problems of hypermobility are getting more and more important. Whereas at high-performance competitive events extraordinary results are achieved in some disciplines by means of early and extremely intensive training aiming at improved flexibility, professional acrobats are not so much the center of attraction as they used to be. This article reports on the basis of examination of 16 competitive sportswomen on a national level, on extreme forms of mobility and on the clinical and radiological findings in "indiarubber" contorsionists and "Klischnigg" acrobats. It was possible to observe and follow up the progression of the extremely rare case of a spondylolysis the lumbar vertebrae L 31 and L 32 as well as concomitant olisthesis L 3/4 and L 5/S 1, over a period of 25 years.

Adolescent↗

[Hemorrhagic enteropathy].

Intestinal infarction in the absence of organic vascular occlusion received increasing attention in recent years. The clinical picture is discussed based on results in 9 cases, an attempt to suggest a possible pathophysiological mechanism is made. Prophylactic digitalisation especially in the elderly patient in the absence of severe heart failure and in cases with already low mesenteric perfusion may lead to a further vasoconstriction and to hemorrhagic enteropathy. Therapeutic possibilities are discussed.

Aged↗

[Conservative treatment of extensor tendon injuries].

Report on 35 cases of mallet finger treated conservatively: a circular plaster cast was modeled in hyperextension of the distal interphalangeal joint. The immobilisation of the whole finger form the tip to the proximal phalanx was maintained for six weeks. The reported results were good or excellent with the exception of two cases.

Casts, Surgical↗

[Verner-Morrison syndrome].

Based on one case the Verner-Morrison-syndrome is demonstrated and discussed in detail. Clinically profuse watery diarrhea and severe hypokalemia are predominant. The pathogenesis is not quite clear. Curative therapy consists in radical surgical removal of the endocrinologically active tumores or diffuse hyperplasia.

Achlorhydria↗

[The local effect of a silver chelate on standardized scald wounds of the rat].

In rat experiments a new silver chelate salt preparation is tested on scald wounds after standardized infection by Pseudomonas aeruginosa. 30% of the animals survive scalding and infection after treatment with the new cream. This percentage does not reach the gentamycin treated reference group (60%). After combining gentamycin and silver chelate salt in local therapy 75% of the animals survive. Combination of silver chelate salt and gentamycin seems to be a very successful local therapy of scald wounds.

Animals↗