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Biomedical subjects

H W Rotthauwe

Publications and source records attributed to H W Rotthauwe.

72 records · Page 4Linked to original sources
PubMedDate not supplied

[Acute-phase proteins and beta 2 microglobulin in the follow-up of Crohn disease and ulcerative colitis].

The concentrations of orosomucoid, CRP, prealbumin and beta-2-microglobulin were measured in 109 serum samples taken from 19 children with M. Crohn and in 62 samples from 7 children with colitis ulcerosa. The levels were correlated with an activity index calculated on the basis of clinical observations and routine laboratory tests. The orosomucoid and CRP levels rose significantly with increasing severity of both diseases, while neither prealbumin nor beta-2-microglobulin revealed a sufficiently close correlation with the clinical activity. The measurement of CRP and orosomucoid, which is simple to carry out (radial immunodiffusion), enables a fairly exact estimate of the severity of inflammation. Both acute-phase-proteins proved to be of valuable assistance not only in difficult decisions regarding therapy but also for follow-up examinations in randomized studies.

Adolescent↗
PubMedDate not supplied

Hepatitis C contributes to liver disease in children and adolescents with hemophilia.

Non-A non-B (NANB) hepatitis plays a major role in liver disease in hemophiliacs. HCV is known to be the predominant cause for blood-borne NANB hepatitis. A cross-sectional study for anti-HCV and anti-HIV-1 antibodies in sera, presence of HBsAg in sera and liver function tests was conducted in 116 male patients with hemophilia (mean age: 14.6 years) in order to study the impact of hepatitis C as well as the significance of concurrent hepatitis B and HIV infection on the liver disease in hemophilic children and adolescents. 56.9% of the patients tested seropositive for anti-HCV; the mean age of the anti-HCV positive group was higher than that of the anti-HCV seronegative group (15.9 versus 11.9 years). Seropositivity to anti-HCV was more often associated with abnormal liver function than it was found in the seronegative group (37.9% versus 17%). Eight of nine patients positive for anti-HCV and HBsAg showed abnormal liver function tests. 68.9% of the anti-HIV-1 positive patients were also anti-HCV positive compared to 44.8% of the anti-HIV-1 negative patients. The liver function tests revealed an abnormal result in 47% of the anti-HIV-1 positive patients compared to 20.7% in the anti-HIV-1 negative group. In conclusion, a high seroprevalence for anti-HCV is detected in young patients with hemophilia which is associated with liver disease in a considerable number of patients when assessed by liver function tests. The coinfection of HCV and HBV seems to increase the risk of liver as also does concurrent HIV-1 infection, which is assumed to contribute to liver disease in a yet unexplained way.

Adolescent↗