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Biomedical subjects

H W Pinotti

Publications and source records attributed to H W Pinotti.

At least 199 records · Page 11Linked to original sources
PubMedDate not supplied

Regeneration of esophageal epithelium in the presence of gastroesophageal reflux.

The esophageal mucosa in twelve dogs was excised from the distal third of the esophagus together with a surgical procedure to provoke gastroesophageal reflux. A longitudinal segment containing all the layers of the wall of the esophagogastric junction was removed intraoperatively in all dogs. It was determined that in this segment, the transition of the columnar and squamous epithelia and the apex of the inferior sphincter of the esophagus, which is perfectly individualized in the dog except for few variations, were at the same level. During the postoperative period, the dogs were randomly divided into two groups according to the time of sacrifice. Group I was killed after 30 days and Group II after 60. Serial sections of the autopsy specimen were taken at the level of the esophagogastric junction, in order to determine the way in which the esophageal epithelium regenerates in the presence of gastroesophageal reflux. The apex of the inferior sphincter of the esophagus was used as a fixed parameter of the esophagogastric transition, even in the absence of its epithelial lining. Postoperatively the dogs presented varying lengths of the inferior third of the esophagus relined with columnar epithelium. The epithelium originates either from the gastric epithelium itself, or from the ducts of the submucosal glands of the esophagus. The histologic aspect of the regenerated columnar epithelium varied from simple columnar epithelium to a well-differentiated epithelium resembling gastric mucosa. These studies reinforce the concept that columnar epithelium lining the terminal esophagus may be acquired due to reepithelization in an acid medium, of a previously injured esophageal epithelium.

Animals↗
PubMedDate not supplied

Histopathology of the common bile duct in choledocholithiasis.

The histology of the common bile duct was studied in 45 patients with choledocholithiasis and/or papillitis and compared with a control group of ten cadavers without hepatic or biliary disease. Choledochitis was diagnosed in 44. Only one patient presented a histologically normal duct. The inflammatory process was characterized by proliferation of connective tissue and loss of elastic fibers, cellular infiltration of lymphocytes and polymorphonuclear leukocytes, and atrophic dilatation or hyperplasic glandular changes. Choledochitis was divided in two types: chronic and acute-chronic, and according to the intensity of the inflammatory process was also classified in slight, moderate or severe. No correlation was found between choledocholithiasis and/or papillitis and type and intensity of choledochitis.

Adult↗
PubMedDate not supplied

Suture of the diaphragmatic esophageal hiatus (an experimental study).

Eighty rabbits were submitted to different procedures on the esophageal hiatus of the diaphragm. The authors concluded that section of the peritoneal lining, removal of the perimysium of the crura of the medial diaphragmatic limb and abrasion of its borders, do not cause local adhesions. On the other hand, the approximation of these muscular structures with interrupted nylon sutures, determines the formation of the scar uniting them. The resistance of the scar varies in different animals but the average values recorded, showed the efficiency of the suture used.

Animals↗
PubMedDate not supplied

Endoscopic treatment of benign postanastomotic annular stricture of the cervical esophagus.

Although most patients presenting with a fibrotic stricture at an esophagocolic or esophagogastric anastomosis respond well to the classical dilation therapy, a number of them do not and are therefore considered to have a condition refractory to the classical method. In these cases, we performed fiberesophagoscopic section and segmentation of the stenosing ring itself, which did not exceed one cm in length, using appropriate equipment such as an electric endoscopic scalpel. Widening of the strictured segment was completed with successive dilations using a Maloney type bougie. Dysphagia disappeared after the endoscopic procedure in 21 (84%) of the 25 patients with stricture of the cervical anastomosis, after esophagocoloplasty or esophagogastroplasty, without any serious complications.

Adolescent↗
PubMedDate not supplied

Esophagogastric anastomosis with valvuloplasty: an experimental study.

Twenty dogs divided into two equal groups were studied by the authors in order to evaluate the functional activity and the occurrence of reflux and esophagitis after esophagogastrectomy followed by a simple esophagogastric anastomosis (group A) and associated with an anti-reflux valve mechanism (group B). The functional activity was studied by manometry at the esophagogastric junction and the occurrence of esophagitis by histologic examination of the esophagus after 25 days of histamine gastric acid stimulation. In group A, no high pressure zone between the gastric and esophageal tracings were verified. Reflux and esophagitis which, occurred in all animals, was severe in 70%. In group B, manometry demonstrated that esophagogastropexy creates a high pressure zone. At deglutition this zone showed positive deflections, corresponding to the propagation of the peristaltic wave in the segment of esophagus, encircled by the stomach. Esophagitis, which was detected in 30%, was less severe than that observed in group A.

Animals↗
PubMedDate not supplied

[Internal biliary fistula: study of 13 cases and review of the literature].

Between 1986 and 1994 13 patients with spontaneous internal biliary fístula were operated at the Hospital das Clínicas of the University of São Paulo. Ten were patients women and three were men. Their mean age was 55.2 years (range 30 to 87 years). The etiology was cholelithiasis in all cases and the most frequent type of fístula was cholecystoduodenal. There was no mortality. A review of literature of this condition and a discussion about the diagnosis, treatment and etiopathogenesis are presented.

Adult↗
PubMedDate not supplied

[Hepatic venous system and its application in the so-called split-liver transplantation technic].

Sixty fresh adult livers were obtained from cadavers together with celiac trunk, head of the pancreas and superior mesenteric artery. The right portal vein, left portal vein and their respective branches were dissected as well as the hepatic veins. There was only one right hepatic vein in 59 cases. The median hepatic vein was present in 53 (88.3%) cases and the left hepatic vein only in 46(76.3%). In 59(98.3%) cases, there were right and left portal vein but in one (1.6%) case no portal bifurcation has been found. The median portal vein has been found only in 9(15.2%) cases.

Adolescent↗