Search PubMed⌕ Search

Biomedical subjects

H W Peel

Publications and source records attributed to H W Peel.

9 recordsLinked to original sources
PubMed1986

Digoxin concentrations in postmortem human tissues.

An extraction procedure is described that allows the application of a commercially available enzyme-multiplied immunoassay technique to the measurement of digoxin in whole blood, liver, and kidney. The concentrations of digoxin were measured in tissues obtained at autopsy from five patients who had been taking therapeutic doses of digoxin prior to death. Blood concentrations at autopsy were found to be higher than the therapeutic range, perhaps due to postmortem redistribution. Liver concentrations of digoxin showed a positive correlation with blood concentrations; this was not found for kidney concentrations of the drug.

Cadaver↗
PubMed1984

Detection of drugs in saliva of impaired drivers.

This study examined the feasibility of detecting drugs using saliva samples obtained from impaired drivers. Screening procedures on 1- to 2-mL samples were for cannabinoids, volatiles, benzodiazepines, and other acidic/neutral/basic drugs. Methodology consisted of enzyme multiple immunoassay technique (EMIT) and temperature programmed gas chromatography with confirmation by gas chromatography/mass spectrometry (GC/MS). Fifty-six samples were obtained from drivers arrested for suspicion of impaired driving. Other than alcohol, the major drugs detected were cannabinoids and diazepam. Cocaine was found in one case.

Automobile Driving↗
PubMedDate not supplied

Toxicological analysis of benzodiazepine-type compounds in post-mortem blood by gas chromatography.

Analytical methodology has been reviewed and investigated to present a rapid method for a qualitative screening and quantitation of a number of benzodiazepine compounds and metabolites. The procedure requires only one millilitre of blood for analysis by gas chromatography (ec). An optional step is included in order to confirm the identity of the compounds by formation of the benzophenone product. Qualitative and quantitative data of the benzodiazepines and related compounds are included.

Adult↗
PubMedDate not supplied

Detection of cannabinoids in blood using EMIT.

A procedure for the detection of cannabinoids in blood (1 mL) using enzyme multiplied immunoassay technique (EMIT) is described. The sensitivity of the method, determined using 11-nor-delta 8-THC-9-carboxylic acid is better than 20 ng/mL. Estimates of precision and a study of storage effects show the method is applicable to blood samples normally encountered in toxicology casework. The method should be useful in screening and selecting blood samples for more specific confirmational procedures.

Cannabinoids↗
PubMedDate not supplied

Monitoring saliva concentrations of methaqualone, codeine, secobarbital, diphenhydramine and diazepam after single oral doses.

A preliminary investigation was undertaken to determine the feasibility of monitoring saliva levels of drugs for forensic purposes. Single oral doses of the title compounds were administered to healthy volunteers. Plasma and saliva levels were measured and ratios calculated for all drugs except diazepam. Saliva/plasma ratios for methaqualone, diphenhydramine and secobarbital were all less than one and reasonably consistent between collection times and subjects. The saliva/plasma ratios for codeine were more variable, but always greater than one. Although more detailed investigation is necessary, saliva may be a useful medium for forensic monitoring of drug ingestion.

Administration, Oral↗