Ethanol-1-C14 and acetate-1-C14 incorporation into lipid fractions in the mouse.
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Biomedical subjects
Publications and source records attributed to H W NEWMAN.
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Cultures on anaerobic medium were made of the spinal fluids of 27 patients with multiple sclerosis and 13 controls after the method described recently by Ichelson. Where Ichelson found organisms resembling spirochetes in 78 per cent of patients with multiple sclerosis, we found some form of what appeared to be a living micro-organism in 18.5 per cent. The control fluids were all sterile. The work requires confirmation and amplification.
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In light of the considerable divergence of opinion among various investigators regarding the incidence of electroencephalographic abnormality in patients with convulsive disorders, the author made a study of his own records of 430 patients with a diagnosis of epilepsy. In 122 the seizures were symptomatic, in the remainder idiopathic, and the overall incidence of electroencephalographic abnormality was little different in the two groups. In the whole series 64.9 per cent showed abnormal tracings, while in those under 16 years of age the incidence was 71.8 per cent. The highest incidence was in patients in whom seizures had begun when they were between 10 and 15 years of age and in those with a duration of seizures from 5 to 10 years. Of patients with clinical petit mal, 76 per cent had abnormal records, but only 34.6 showed petit mal complexes. Lateralized or focal abnormality was three times as frequent in the symptomatic as in the idiopathic group.
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Epidemiologic surveys of multiple sclerosis were conducted in 1949 in San Francisco, Winnipeg, Boston, New Orleans, and Denver. Reports of cases for 1939 through 1948 were obtained from record offices, hospitals and clinics, and private physicians. The basis for the observations was the group of "probable" cases among residents. In San Francisco these probable cases in residents numbered 415; however, in only 146 of these was the onset between 1939 and 1948. Of the 143 patients who were white, 51 were male and 92 female. The average annual incidence based on these figures was 2.1 per 100,000-1.5 for males and 2.6 for females.Prevalence, based on probable cases in residents on January 1, 1949, was 29.7 cases per 100,000 population-21.2 for males and 38.1 for females. Mortality was 0.7 per 100,000 population-0.9 for females and 0.6 for males. In comparison of the findings for San Francisco with those of other cities, both the incidence and the severity of the disease appear to decrease from north to south.
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