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Biomedical subjects

H W Klemmer

Publications and source records attributed to H W Klemmer.

8 recordsLinked to original sources
PubMed1978

Five cases of intentional ingestion of 25 percent diazinon with treatment and recovery.

The use of atropine to block the effects of acetylcholine and pralidoxime chloride to restore cholinesterase in the blood, along with supportative therapy, intravenous fluids, and oxygen, prevented death in five cases of intentional ingestion of 25% diazinon. Treatment of such cases must be tailored to the condition of the patient, and all residual poison in the stomach must be removed as rapidly as possible with gastric lavage to prevent absorption of the poison.

Acetylcholine↗
PubMed1977

Human tissue distribution of cyclodiene pesticides-Hawaii 1964-1973.

Data have been presented covering symptoms of acute exposure to cyclodiene pesticides in adults and infants in Hawaii. Varying concentrations of heptachlor epoxide, dieldrin, DDT, DDE, and DDD were found in human autopsy material, with the highest levels of heptachlor epoxide in bone marrow and liver and those of dieldrin in kidney and gonad. Maximum concentration of dieldrin in human milk was 0.25 ppm on an extracted lipid basis; in fetal tissues, 1.46 ppm; and in maternal tissues, 2.04 ppm. There was correlation between dieldrin concentration in household dust and human blood serum. The general baseline levels of cyclodiene pesticides were lower in Hawaii than the rest of the United States.

Autopsy↗
PubMed1977

Association between renal function tests and pentachlorophenol exposure.

Data are presented and renal function tests and Pcp measurements on consecutive blood and urine samples collected from 18 workers at a wood treatment plant before, during, and after a 20-day vacation. Pcp concentrations in blood averaging 5.1 ppm before vacation fell to 2.2 ppm during vacation but with a temporary rise early in this nonexposure period, suggesting a body tissues store of Pcp which was mobilized in response to a negative Pcp balance. Urine Pcp concentrations showed similar but less marked variations. Creatinine clearance and phosphorus reabsorption values were depressed before vacation but showed significant improvement during vacation, suggesting that Pcp exposure reduced both glomerular filtration rate and tubular function, with recovery following a nonexposure period.

Chlorophenols↗