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H W Goedde

Publications and source records attributed to H W Goedde.

312 records · Page 18Linked to original sources
PubMedDate not supplied

Effect of acute ethanol drinking on alcohol metabolism in subjects with different ADH and ALDH genotypes.

The effect of different amounts of orally ingested ethanol on plasma alcohol dehydrogenase (ADH) and erythrocyte aldehyde dehydrogenase (ALDH), as well as on the blood ethanol and acetaldehyde levels, was examined in healthy nonalcoholic subjects. The genotypes at ADH2 and ALDH2 locus were identified in enzymatically amplified blood DNA by hybridization with allele-specific oligonucleotides. While the Japanese subject was found to be genotypically heterozygous for both ADH2 and ALDH2, the Caucasian subjects were genotypically homozygous normal for these alleles. A faster ethanol elimination associated with a higher blood acetaldehyde level was observed in the Japanese subject as compared to Caucasian subjects. However, no significant change in ADH and ALDH enzyme activities was detected as the result of acute ethanol intake.

Acetaldehyde↗
PubMedDate not supplied

Distribution of eight blood-group systems and ABH secretion in Mongolian, Korean, and Zhuang nationalities in China.

Among different blood-group systems investigated here, the distribution of the ABO system varies most of all, followed by MNSs and P. Although there are differences in ABH secretion in the different populations, no striking regularity has been found. No significant difference has been found in the distribution of the blood-group systems Rhesus, Diego, Duffy, Kell and Kidd in these Chinese populations: the Rh (-) rate is less than 1%, the frequency of Dia is about 0.04, the frequency of Fya is rather high, the frequency of K extremely low and Jka is about 0.4. In the three nationalities under study, Mongolians are characterized by a high frequency of IB, M higher than 0.5 and a relatively high frequency of P1. Koreans are characterized by a high frequency of IA, slightly more M than N and rather high CDE in the Rh system. The peculiarities of the Zhuangs are a rather high frequency of IO and M and the lowest frequency of P1.

ABO Blood-Group System↗
PubMedDate not supplied

Genetic studies in Atacameño Indians: serum protein and red cell-enzyme polymorphisms.

Phenotype and gene frequencies among Atacameño Indians are presented for nine serum protein polymorphisms (Hp, Gc with subtypes, Tf with subtypes, Amy, C3, Bf, PLG) and nine red-cell-enzyme polymorphisms (AcP, PGM1 with subtypes, AK, ADA, 6-PGD, GPT, EsD, GLO). Four systems--Tf, Amy, AK, ADA were found to be monomorphic. In the PGM1 subtypes an extremely high frequency of PGM1a3 could be observed. In two samples a new Gc mutant was identified and classified as Gc1A26. In the EsD system an unusual phenotype was detected in one sample.

Adult↗