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Biomedical subjects

H W Goedde

Publications and source records attributed to H W Goedde.

At least 217 records · Page 12Linked to original sources
PubMed1975

The serum immunoglobulin levels in Down's syndrome and other diseases associated with mental disorder.

The serum levels of IgA, IgM, IgG and IgD were determined in patients with Down's syndrome (69 cases), Oligophrenia (101 cases) and Morbus Wilson (18 cases). In sera from Down's syndrome patients a significant increase in the levels of IgA, IgG and IgD were found. IgM levels were identical to those of healthy controls. The immunoglobulin levels in both the oligophrenia and Wilson's disease patients were not different from those of controls.

Down Syndrome↗
PubMed1975

[A spectrophotometric method for the determination of serum cholinesterase variants with succinyl choline as substrate (author's transl)].

A simple and rapid method for the estimation of the hydrolysis of succinyl choline by serum cholinesterase variants is described. Succinyl choline, as substrate for the enzyme assay, has many advantages over other substrates (acetyl choline, benzoyl choline and butyryl choline) which have no clinical application. Choline, the hydrolytic product of succinyl choline, is oxidized to betaine aldehyde by choline oxidase (EC 1.1.99.1), a rat liver mitochondrial preparation; this is coupled to the reduction of cytochrome c which is measured at 550 nm. Fifty normal sera (UU), 17 heterozygous (UA) and 8 atypical (AA) were tested with this method, and on the basis of resistance to dibucaine (Cinchocain; Kalow, W. & Genest, K. (1957) Canad. J. Biochem. Physiol. 35, 339-346) inhibition, three distinct groups could be established using succinyl choline as substrate. These results are comparable with the standard optical method of Kalow & Genest (cf. above) using benzoyl choline as substrate.

Anesthesia↗