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Biomedical subjects

H W Chin

Publications and source records attributed to H W Chin.

43 records · Page 3Linked to original sources
PubMed1981

Reoperation for glioblastoma.

The results of a second operation for tumor removal in 24 adult patients with supratentorial glioblastoma multiforme or anaplastic astrocytoma were analyzed. The median survival time after reoperation was 14 weeks. Five of the 24 patients lived 6 months or longer after reoperation. Only three of these patients maintained a Karnofsky rating (KR) of at least 60 for 6 months or longer after reoperation. Preoperative neurological status (KR) is the most significant determinant of survival after reoperation (p = 0.02). When the KR is at least 60, median survival after reoperation is 22 weeks. When the KR prior to reoperation is less than 60, median survival is 9 weeks. Only one of 13 patients with a KR of less than 60 prior to reoperation survived longer than 6 months after the second operation. The interval between first and second operation is significantly related to survival (p = 0.03), but when adjustment is made for the KR the interoperative interval is no longer significantly related to survival after the second operation (p = 0.39). Age, sex, and location of tumor were not significantly related to duration of survival. This study suggests that reoperation is most likely to produce the best result when the KR is at least 60 and the interval between operations is longer than 6 months. Using these criteria, one-third of the patients could be expected to survive with a KR of at least 60 for 6 months. The study indicates that reoperation should not be carried out when the KR is less than 60.

Adult↗
PubMed1980

Oligodendrogliomas. I. A clinical study of cerebral oligodendrogliomas.

Fifty-four patients with oligodendroglioma presented in the past 15 years. In contrast to some widely taught concepts, oligodendrogliomas occured largely in the frontotemporal area of both cerebral hemispheres with two peaks of age incidence: one small peak in childhood, and the highest incidence in the middle-aged adult. Seizures, either major and/or minor, were the most common clinical manifestations (average 87%). Cerebral angiography and pneumography were the most reliable and useful diagnostic procedures, as well as the promising CAT scan. All 24 patients who underwent combined modalities of treatment with radical surgery and postoperative radiation therapy survived at least five years, and 2 out of 11 patients treated by surgery alone failed to survive the five-year follow-up period in addition to two recurrences. Postoperative radiation treatment is considered quite effective and indicated in most cases because complete removal of the tumor is not always possible.

Adolescent↗
PubMed1980

Breast cancer and axillary nodal status.

We reviewed 280 patients with breast cancer to evaluate the significance of auxillary nodal status in relation to the natural course of disease. Based on axillary node involvement, we classified our patients into three groups. With negative nodes (localized phase) 73% of patients survived more than 10 years; with one to three positive nodes (latent phase) 48% of patients survived 10 years; and with massive nodal metastases (generalized phase) 20% of patients survived 10 years.

Adult↗
PubMedDate not supplied

Survival response of malignant gliomas to radiotherapy with or without BCNU or methyl-CCNU chemotherapy at the University of Kentucky Medical Center.

A total of 115 patients were randomly assigned to one of six therapeutic groups within 3 weeks from craniotomy as part of the Brain Tumor Study Group protocols. In category A (surgery without radiotherapy) there was no significant difference in survival between supportive care only and chemotherapy (BCNU or methyl-CCNU) groups. More than one half of patients in this category died within 6 months of surgery. In category B the addition of 6000 rad of whole-brain radiation treatment to the surgery increased survival time significantly: the 6-month survival rate was two to three times that observed in category A. More than 50% of patients were alive at 1 year and at least 20% survived 2 years. The best survival rate in this study was obtained in patients who received methyl-CCNU with irradiation. The duration of survival was increased to nearly two times that of the radiotherapy group and to six times that of the surgery only group. Reasons for this are discussed.

Adolescent↗
PubMedDate not supplied

Radiotherapy alone for extradural compression by spinal myeloma.

Between 1976 and 1992, 18 patients with a histologically proven diagnosis of plasma cell myeloma (PCM) were treated for palliation of spinal extradural compression (EC) by radiotherapy alone. Eighty-five percent of the evaluable symptomatic individuals obtained significant pain relief. Ambulatory ability was retained or regained in 11 (65%) patients. The overall median period of survival was 11 months. Extended median survival was noted in post-treatment ambulatory patients (compared with nonambulatory patients) and in individuals whose primary presentation of PCM was EC (versus individuals who developed EC during the course of the disease). These results suggest that radiotherapy alone may be used in the palliative management of patients with EC by PCM.

Aged↗