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Biomedical subjects

H W Bonekat

Publications and source records attributed to H W Bonekat.

20 records · Page 2Linked to original sources

Diagnosis of obstructive sleep apnea.

The diagnosis of obstructive sleep apnea is frequently made by taking a meticulous history coupled with a high index of suspicion. Snoring and hypersomnolence are clinical features common to individuals with sleep apnea. Since snoring is said to be a "disease of listeners," it is not uncommon that bed partners reported an increased incidence of depression and marital displeasure. It is for this reason that the spouse or bed partner should be interviewed, since the patient may not be aware of any sleeping problems. Physicians should also be alert to complaints of excessive daytime somnolence, because studies have shown that patients with obstructive sleep apnea are at increased risk for automobile crashes. It has been estimated that approx 58,000 motor vehicle accidents involving people with sleep apnea will occur in the US each yr. By proper diagnosis and treatment, the physician is in a unique position to prevent at least some of the automobile accidents that result from falling asleep while driving. Polysomnography is the only definitive way to obtain a diagnosis of sleep apnea. This allows the physician not only to diagnosis the disorder, but also helps in the evaluation of the severity of the syndrome and selection of therapy. An ENT evaluation is also important in ruling out anatomic disorders that can cause upper airway obstruction. Certain factors, such as alcohol and sedative ingestion, may aggravate the condition in a person predisposed to sleep apnea, and subtle changes, such as unexplained hypertension, polycythemia, and cor pulmonale, should lead one to investigate the possibility of sleep apnea as the etiology.

Disorders of Excessive Somnolence↗

Age and fitness effects on EEG, ERPs, visual sensitivity, and cognition.

Measures of EEG, event-related potentials (ERPs), visual sensitivity, and cognition were obtained from 30 young (20-31 years) and 30 older (50-62 years) healthy men. Age groups were evenly divided between subjects with low and high fitness levels documented by VO2max during a maximal exercise test. Age comparisons revealed that, compared to young adults, the older men had reduced visual sensitivity, delayed ERP latencies, greater homogeneity of EEG activity across recording sites, more positive visual-evoked potential (VEP) amplitude-intensity (A/I) slope, and poorer performance on a battery of neurocognitive tests. The EEG and VEP A/I slope findings are believed to reflect weakened central inhibition for the older men. In general, the measures that differentiated groups on the basis of age were also sensitive to differences in aerobic fitness. Compared to low fit men, the physically active men had shorter ERP latencies, stronger central inhibition, better neurocognitive performance, and better visual sensitivity. We speculate the performance superiority of the physically active men was, at least in part, the result of more oxygen being available for cerebral metabolism.

Adult↗