Rights-responsibilities and health care.
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Biomedical subjects
Publications and source records attributed to H W Allen.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
A new method for the analysis of ritalinic acid, the major metabolite of methylphenidate in urine, is described. The procedure involves solid-phase extraction of ritalinic acid from urine using C-18 reverse phase columns. The ritalinic acid is methylated to form methylphenidate which, together with an internal standard, is then extracted into chloroform and analyzed by gas chromatography using a flame ionization detector. This procedure gives essentially quantitative recovery of ritalinic acid from 10 mL urine and is linear in the range of 0 to 10 micrograms/mL. A positive analysis for ritalinic acid is confirmed by thin-layer chromatography. Detection sensitivities of greater than or equal to 1 micrograms/mL urine were observed for both procedures.
Pyogenic sacroiliitis is an uncommon infection often diagnosed late because of poor localization of symptoms and inadequate physical examination. We describe a 12-year-old girl whose osteomyelitis and pyogenic sacroiliitis was initially misdiagnosed and discuss examination, investigation and management of the condition. This case highlights the importance of thorough physical examination and the consideration of septic arthritis in an unusual joint.