Three cases are reported of cholestatic hepatitis occurring during treatment with rifampicin for staphylococcal septicemia (2) and tuberculosis (1). There was no previous history of hepatic affection. The administration of rifampicin caused cholestasis alone. No immunoallergic phenomenon has been shown.

Aged↗

PubMedDate not supplied

[Systemic complications of beta-blocking eyedrops. Apropos of 6 cases].

Six cases of systemic reactions to topical treatment with beta-blocking eyedrops are reported, bradycardia and faintness due to an overdosage of ophthalmic timolol; decompensated heart failure one month after the prescription of carteolol eyedrops: bronchospasm after two weeks of treatment with metipranolol eyedrops; crippling Raynaud's phenomenon of otherwise unknown origin, which had begun with timolol eyedrops, continued with carteolol eyedrops and regressed after discontinuation of ophthalmic beta-blockers; aggravation of an anaphylactoid shock in a patient treated with ophthalmic timolol, and myocardial infarction possibly due to the abrupt withdrawal of timolol eyedrops. It cannot be overstressed that the rules governing the prescription of oral beta-blockers also apply to ophthalmic preparations of these drugs: respect of contra-indications, strict adherence to the dosage recommended, gradual drug withdrawal and regular supervision. Only controlled studies and long-term follow-up will be able to demonstrate differences in safety between the five beta-blockers commercialized as eyedrops in this country.

Adrenergic beta-Antagonists↗

PubMedDate not supplied

[Polycythemia secondary to hepatic hemangioma. Demonstration of tumoral erythropoietin secretion].

We report the case of a 37-year old man with polycythemia related to hepatic tumor with elevated serum erythropoietin concentrations. Left hepatic lobectomy was performed 20 months after admission. Microscopic examination revealed a typical hemangioma. Erythropoietin in tumoral extract was elevated. Two months later, the hematocrit and the serum erythropoietin level were within normal range. To our know-ledge, this is the first report in literature.

Adult↗

PubMedDate not supplied

[Desensitization in HIV seropositive patients with cotrimoxazole hypersensitivity. A series of 18 cases].

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Adult↗