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Biomedical subjects

H Vermeulen

Publications and source records attributed to H Vermeulen.

14 recordsLinked to original sources
PubMed1992

Effect of intravenous hypnotics on the actions of pipecuronium.

Seventy-five ASA Grades I-III patients (18-85 years, 45-90 kg) were randomized into five groups. All patients received N2O/O2 (2/1) and alfentanil: loading dose (LD) 0.015 mg kg-1 and maintenance dose (MD) 0.045 mg kg-1 h-1 (groups 1-4). Group 1 received propofol (LD 2 mg kg-1 and MD 6 mg kg-1 h-1); Group 2 etomidate (LD 0.3 mg kg-1 and MD 0.6 mg kg-1 h-1); Group 3 midazolam (LD 0.2 mg kg-1 and MD 0.120 mg kg-1 h-1); Group 4 methohexitone (LD 1.5 mg kg-1 and MD 4 mg kg-1 h-1); Group 5 dehydrobenzperidol 0.05-0.23 mg kg-1 and alfentanil (LD 0.100 mg kg-1 and MD 0.060 mg kg-1 h-1). The neuromuscular block induced by pipecuronium (50 micrograms kg-1) was evaluated. No statistically significant differences were found between the five groups as concerned degree of block (expressed as % twitch amplitude in response to the first of the TOF stimuli (Ta1) at intubation, T1 minimum and recovery to Ta1 = 20%, 25% and 75%. Slightly faster intubation was possible when midazolam was used in comparison with propofol, methohexitone or NLA and when etomidate was used in comparison with propofol. A wide range of individual values of maximal neuromuscular blocking activity was found.

Adult↗
PubMed1991

Possible inadvertent subdural block following attempted stellate ganglion blockade.

A case is reported of suspected inadvertent subdural block following attempted stellate ganglion blockade for relief of cervicobrachial pain in a patient suffering from reflex sympathetic dystrophy. Possible complications due to neuraxial spread of local anaesthetics while performing a cervicothoracic ganglion blockade are considered.

Adult↗
PubMed1991

Spinal cord stimulation in chronic pain: evaluation of results, complications, and technical considerations in sixty-nine patients.

Sixty-nine patients undergoing spinal cord stimulation (SCS) were studied for a period of up to 8 years. Indications, implantation techniques, and stimulation systems are presented in this article. Pain-suppressor effects of SCS are reviewed, assessing the clinical efficacy over time as well as complications with the stimulation device. Immediately following implantation, inadequate pain relief was noted in 20% of the patients. Decrease of the efficacy of pain alleviation occurs during the first 3 years after implantation. Most failures are noted in patients presenting with failed back surgery. This study also demonstrates that SCS systems should offer the capability of both monopolar and bipolar stimulation modes by the use of multipolar electrodes.

Chronic Disease↗
PubMed1988

Noncompartmental pharmacokinetic analysis of nondepolarising neuromuscular blocking agents.

Noncompartmental pharmacokinetic methods using the statistical moment theory can be very helpful in comparing the mean residence time of drugs in the body. These methods are based on the estimation of the area under the time versus plasma concentration curve after a single intravenous drug bolus, and can also be used to estimate clearance, effective half life and the apparent volume of distribution of the drug. In the group of nondepolarising neuromuscular blocking drugs, atracurium offers the advantage of having the smallest mean residence time.

Half-Life↗
PubMed1987

Intrathecal sufentanil as a supplement to subarachnoid anaesthesia with lignocaine.

The combination of low-dose sufentanil with lignocaine for subarachnoid anaesthesia was studied in a double-blind comparative trial in 40 urological patients. Patients were allocated randomly to two groups and received 5% heavy lignocaine 1.5 ml together with either 1.5 ml of sufentanil 5 micrograms ml-1, or physiological saline 1.5 ml. No statistically significant differences were observed between the two groups with respect to analgesia or anaesthesia. The only clear benefit of the addition of a low dose of sufentanil to lignocaine was the significantly longer period of postoperative analgesia. There was no significant difference in the number of patients requiring supplementary analgesics. Side-effects were similar in both groups.

Adjuvants, Anesthesia↗
PubMed1982

Physical work capacity and classroom attention of handicapped and non-handicapped children.

The relationship between Physical Work Capacity (PWC) and 'attention in the classroom' was examined using a differential design, with 15 handicapped (age range 94-167 months) and 20 non-handicapped children (age range 91-141 months). The PWC was measured with the aid of a bicycle ergometer and the childrens' attention by means of an observation instrument developed for the purpose. On both variables the non-handicapped children differed significantly from the handicapped children. A low, non-significant relationship was found between scores obtained from the observaton instrument and a teachers' questionnaire for classroom attentional behaviour. The correlation between PWC and 'attention in the classroom' within the two groups was found to be non-significant but different in sign. This suggested relationship betwen PWC and attention merits further study. Suggestions are made with respect to physical training programmes for handicapped children.

Attention↗