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Biomedical subjects

H Van Poppel

Publications and source records attributed to H Van Poppel.

At least 19 recordsLinked to original sources
PubMed1992

Trisomy 7 and trisomy 10 characterize subpopulations of tumor-infiltrating lymphocytes in kidney tumors and in the surrounding kidney tissue.

We performed conventional cytogenetic analysis and fluorescence in situ hybridization in short-term cultures of normal and neoplastic kidney tissues. Cell populations carrying an extra chromosome 7 or an extra chromosome 10 as the only chromosome change could be identified in kidney tumors, mostly renal cell carcinomas, and in the surrounding kidney tissue, but not in nonneoplastic kidneys. To identify the type of cells displaying these aneuploidies, we performed in situ hybridization (ISH) with probes specific for the centromeric region of chromosomes 7 and 10 on frozen kidney tissue sections. Trisomy 7 and trisomy 10 were restricted to infiltrating inflammatory cells in the tumor as well as in the surrounding tissue. Trisomy 7 and trisomy 10 were also found in subpopulations of peripheral blood T cells of cancer patients and of normal individuals, as well as in the thymus of five normal fetuses (21-29 weeks), but not in noninvaded reactive lymph node sections of patients without malignancy. When lymphocytes were enriched from kidney tumors and surrounding tissue by either Ficoll/Hypaque density gradient or immunomagnetic selection with anti-CD3, anti-CD4, or anti-CD8 monoclonal antibodies, it was confirmed that they contained a high percentage of trisomy 7 and trisomy 10 cells. Further proof for T-lymphocyte origin of the trisomy 7 and trisomy 10 cells was obtained by simultaneous staining of lymphocytes isolated from tumor tissue with anti-CD3, anti-CD4, and anti-CD8 monoclonal antibodies and ISH. We conclude that trisomy 7 and trisomy 10, found in renal carcinomas and surrounding kidney tissue, characterize subpopulations of tumor-infiltrating lymphocytes. The biologic significance of this phenomenon is unknown and requires further investigation.

Chromosomes, Human, Pair 10↗
PubMed1992

Treatment of lower urinary tract dysfunction in patients with multiple sclerosis. Committee of the European Study Group of SUDIMS (Sexual and Urological Disorders in Multiple Sclerosis)

Bladder symptoms in patients with multiple sclerosis (MS) are common and usually arise as a result of spinal lesions which interrupt the neural pathways connecting the pontine micturition centre to the sacral spinal cord. Thus these symptoms are particularly likely to occur in those with lower limb neurological deficits. Fortunately bladder dysfunction in MS is rarely associated with serious upper tract disease so that the problem is usually one of symptomatic management. Lower urinary tract symptoms may be both "irritative" or "obstructive" in nature and can be explained in terms of underlying detrusor hyperreflexia and incomplete bladder emptying. Treatment is aimed at minimising both these effects. Oral anticholinergic medication can be effective in reducing detrusor hyperreflexia and intermittent catheterisation is used to reduce abnormally high post micturition residual volumes. With this simple treatment, often used in combination, many less severely affected patients with MS can gain considerable improvement in controlling urinary continence.

Administration, Oral↗
PubMed1992

A pseudotumoral edema of the urinary bladder secondary to an intramural impacted ureteral lithiasis.

A case of pseudotumor of the urinary bladder secondary to intramural lithiasis is reported. Computer tomography, cystoscopy of the mass and cytology suggested a malignant tumor. A transurethral biopsy from the tumor was therefore performed, but it showed tissue covered with normal transitional cell epithelium but no signs of malignancy. Pseudotumoral edema of the bladder is easily mistaken for a malignant neoplasm (1, 2, 3).

Aged↗
PubMed1992

Radical prostatectomy for localized prostate cancer.

A retrospective analysis of 70 patients, undergoing a radical prostatectomy in 1989 and 1990 is reported. The value of computed tomography (CT) scanning in preoperative lymph node staging should be reconsidered. Evaluation of the resection margins is of utmost importance as is the distinction between capsular invasion, penetration and transgression. The etiology of local failure and its treatment are discussed.

Adenocarcinoma↗
PubMed1992

Neo-adjuvant hormonotherapy does not facilitate radical prostatectomy.

Sixty-eight patients who underwent radical prostatectomy without or after neo-adjuvant hormonotherapy for B2 or C stage prostate cancer were evaluated as concerned to the ease of the surgical procedure. Although it is difficult to assess this parameter, we experienced more difficulties and blood loss was higher in patients who had preoperative hormonal deprivation. Ongoing randomized trials could demonstrate an oncological benefit of neo-adjuvant hormonotherapy before radical prostatectomy. This eventual benefit will have to be balanced against an increased surgical difficulty.

Aged↗
PubMed1991

Review of modern trends in the treatment of chronic bacterial prostatitis (C.B.P.).

Careful, lower urinary tract localization studies have to be used to classify patients in the chronic bacterial prostatitis group and others. Considerable progress has been made in understanding the pathophysiology and developing rational approaches for treatment of patients with chronic bacterial prostatitis. Ciprofloxacin is a new quinolone carboxylic acid derivate with marked activity against both gram-negative and gram-positive bacteria. A critical analysis of the most recent achievements in the area of chronic bacterial prostatitis is presented.

Animals↗
PubMed1991

The percutaneous operative gastrostomy for gastric decompression in major urological surgery.

When postoperative gastric decompression is necessary a percutaneous gastrostomy tube is an alternative to nasogastric intubation. The percutaneous insertion of a suprapubic bladder catheter is an easy procedure without notable complications that increases the comfort of the patient in the immediate postoperative period. We advocate its use in all major urological abdominal operations.

Aged↗
PubMed1991

Is there a place for conservative surgery in the treatment of renal carcinoma?

Since 1981, 31 patients have undergone conservative surgery for malignant renal tumours and have been followed up for at least 2 years. The techniques included enucleation or resection (wedge resection or partial nephrectomy). In 10 patients the indications for kidney-sparing surgery were absolute, while in the remainder the conservative surgical approach was a deliberate choice. The tumours varied in diameter from 1.3 to 12 cm and no metastases were detected on pre-operative screening. One patient died post-operatively from myocardial infarction. In the remaining 30 there were no local recurrences. Two patients died from skeletal metastases (1 with bilateral malignancy) and 2 underwent surgery in the post-operative period for haemorrhagic complications. The efficacy of conservative surgery in the local control of renal cancer is an argument in favour of its wider use.

Adenocarcinoma↗
PubMed1991

Experience with the intraprostatic spiral.

Thirty-six patients have been followed up after insertion of an indwelling intraurethral device for prostatic obstruction. Follow-up exceeded 1 year in some cases. The main problem was dislocation of the spiral not only in the early stages but also after several months. Endoscopic assessment of the obstruction seems important during the pre-operative investigations. The ideal indication is prostatic obstruction in patients who are unsuitable for surgery and who need relief of acute retention for a limited time only. In selected patients the prostatic spiral has a place in the treatment of obstructive prostatism.

Catheters, Indwelling↗
PubMed1991

Balloon dilation of the prostate. Critical evaluation.

We describe the results of prostatic balloon dilation in 7 patients with a follow-up of 9 months. Symptom scores dramatically fell in 5 patients (success rate 71%), which is confirmed by a significant improvement in peak flow in 4 of them. Two patients failed to improve and needed a subsequent intervention which revealed a stage A2 prostatic carcinoma in one. During subsequent open prostatectomy, a condition analogous to dilation with the Deisting dilator was seen. We conclude that the indications and results obtained with the balloon dilator are similar to those with the Deisting dilator.

Aged↗
PubMed1991

[Transuretero-pyelostomy for ureteral necrosis following a Mainz continent umbilical urinary diversion].

A female patient, undergoing a radical cystectomy and a continent urinary diversion in the umbilicus (after multiple gynecological interventions and 40 Gy radiotherapy) presented a stenosis of the left ureter. After 6 months a uretero-pyelostomy (left-right) was performed mediating a bilateral lumbotomy. This approach has prevented a nephrectomy or a laparotomy which could compromise the continence mechanism of the pouch.

Female↗
PubMed1991

[Radical prostatectomy for localized prostatic cancer].

A retrospective study of 70 patients who underwent a radical prostatectomy in 1989 and 1990 was done. The significance of CT-scan in preoperative lymph node assessment should be reconsidered. The correct examination of the resection margins is very important: the pathologist should clearly distinguish between capsular invasion and capsular penetration or transgression. The etiology of local failure and its treatment are discussed.

Humans↗