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Biomedical subjects

H Valensise

Publications and source records attributed to H Valensise.

At least 73 records · Page 4Linked to original sources
PubMed1988

Effect of general anesthesia on syncytiotrophoblast plasma membranes from human placenta.

This investigation shows that a general anesthetic produces similar effects in vivo and in vitro. Anesthesia with a barbituric drug, Thiopental, induces an increase in membrane fluidity and a decrease in the activity of acetylcholinesterase in syncytiotrophoblast plasma membranes (SPM) obtained from placentas after caesarean section. The same effects can be reproduced in vitro after anesthetic addition to the isolated plasma membranes. Morphological and freeze-fracturing studies also suggest that membrane protein components are affected by anesthetics.

Acetylcholinesterase↗
PubMedDate not supplied

The fetal behavioural states: an ultrasonic study.

In order to accurately detect the fetal behavioural state, we simultaneously measured fetal heart rate and multiple fetal activities in 27 healthy pregnant women at 38 to 40 weeks of gestation. We ultrasonically identified gross body movements, breathing movements and micturition. Analysis of fetal heart rate allowed us to distinguish two different patterns of fetal behaviour: active and quiet phases. The frequency distribution of the analysed fetal events was significantly different in these two phases. These data suggest that a complete biophysical profile of the fetus is effective in differentiating behavioural states and may improve the predictive accuracy of fetal heart rate analysis alone.

Adult↗
PubMedDate not supplied

The development of fetal behavioural states: a longitudinal study.

In order to evaluate the development of fetal behavioural states a longitudinal study was performed on 35 healthy fetuses during the last trimester of pregnancy. Fetal heart rate (FHR), gross fetal body movements (FM), fetal eye movements (FEM), fetal breathing movements (FBM) and micturition were simultaneously studied at two-week intervals from 28 weeks gestation onwards. Well-defined fetal behavioural states were observed only after 36 weeks gestation. Between 28 and 36 weeks the quiet-activity cycle of FHR was always detected and some fetal biophysical activities seemed to become related around this cycle.

Eye Movements↗
PubMedDate not supplied

Modifications of ultradian and circadian rhythms of fetal heart rate after fetal-maternal adrenal gland suppression: a double blind study.

In order to verify whether fetal and maternal adrenal gland suppression induces effects on fetal behaviour, triamcinolone was administered to five healthy pregnant women at 35 weeks of gestation. Five patients of the same gestational age were used as control. Fetal heart rate (FHR) and fetal movements were recorded continuously over 2-h interval by means of cardiotocography. After 3 weeks (38 weeks of gestation) the recordings were repeated without drug administration. Cortisol, adrenocorticotropin hormone, 17 beta-estradiol and unconjugated estriol were measured at the same time every 2 h in maternal peripheral plasma. At 35 weeks we found a loss of circadian rhythms of the hormones investigated and modifications of ultradian and circadian patterns of FHR in the treated group with respect to the control. No differences in hormonal and biophysical parameters were found between the two groups after the end of treatment (38 weeks). These data suggest that the inhibition of fetal and maternal adrenal glands could cause modifications of FHR patterns.

Activity Cycles↗
PubMedDate not supplied

[Transvaginal echography in the evaluation of the grade of myometrial invasion in locally advanced endometrial carcinoma].

Neoplastic myometrial invasion is an important prognostic factor in local advanced endometrial carcinoma, conditioning therapeutic choice. In 34 patients with stage I and II endometrial carcinoma, the depth of myometrial invasion was evaluated by transvaginal sonography (TVS). In comparison with pathological findings, TVS showed an overall accuracy of 82.3% with a sensitivity of 82.6% and a specificity of 81.8%. The principal error was related to the underestimation of the lesion: negative predictive value of 49.2% vs positive predictive value of 90.4%. In conclusion, TVS is an accurate imaging method for staging of local advanced endometrial carcinoma.

Adult↗
PubMedDate not supplied

Fetal behavioural states and hypertensive pregnancy.

Delay in fetal maturation in diabetic and accelerated fetal maturation in hypertensive pregnancies have been reported in the past. The spontaneous activity of fetal nervous system during pregnancy was followed longitudinally in a group of 29 normal pregnancies from 28 x th to 40 x th week of gestation by means of fetal behavioural states determination. 1 F state (quiet sleep) progressively increases from median values of 5.0% to values of 22.5-25% at term of pregnancy. This state represents the positive activity of inhibitory centers has been related to a positive evolutionary process of brain maturation according to preceding experiences conducted on experimental models and preterm babies followed with EEG and direct observation in the early neonatal period. The method of behavioural states determination has been applied to a group of 33 gestational diabetes (GDM) pregnant women followed longitudinally, and a clear reduction of development of 1 F state has been evidentiated, with significant differences (p less than 0.001) at 35-36 weeks of gestation versus the control group. The normal values are reached in concomitance with L/S value of maturity. In 30 pregnant women affected by gestational hypertension (GH) different result are obtained: 1 F state seems to develop earlier, and is increased (p less than 0.001) around 30-32 weeks versus the control group if a fetal growth reduction is present. The value of 1 F behavioural state in the evaluation of fetal condition of pathological pregnancies is discussed.

Blood Pressure↗
PubMedDate not supplied

[Telephone transmission of the cardiotocographic recording from the office to the obstetrical clinic].

The authors describe their experience in telephonic transmission of cardiographic recordings. With a Corometrics 116 and 410 unit installed in a remote facility, 61 CTG recordings were tele transmitted and received by a Toshiba personal computer. The comparison between original and transmitted CTG record was excellent and a very low percentage of signal loss during transmission (3.2%). The advantages of telephone transmission of CTG in peripheral areas are stressed.

Cardiotocography↗
PubMedDate not supplied

[Computerized cardiotocographic assessment with the "8000 System". I. Construction of normal curves].

The construction of referral curves for the computerized ctg parameters may increase the clinical efficacy of the examinations in tracings of unfavourable interpretation. With the help of "System 8000" software, the longitudinal variation of computerized parameters fetal movements/hour, fetal movements in high and low variability, accelerations, length of high and low variability periods, mean range and value of short variability have been analyzed in a group of 12 low risk patients followed biweekly from the 24-26th week of gestation through term. While accelerations, minutes of low and high variability showed an absence of significative variation during pregnancy (F = 1.78; F = 9.3, F = 4.5 P = n.s.), significant (p less than 0.001) variation showed the other parameters. Number of movements/h and movements in high variability had an increase from 24-26 weeks to 32-34 weeks and a progressive further decrease till term; movements in low variability disappear after 32-34 weeks of gestation; mean range and short variability increase until 34 weeks and remained stable till end. Therefore the results obtained are in use for the high risk fetuses that perform a computerized ctg registration: nevertheless, the longitudinal evaluation reveals the maturation of fetal central nervous control on heart rate and fetal movements after the 34-36th weeks of gestation as a shown from behavioural states evaluation.

Analysis of Variance↗
PubMedDate not supplied

[Tumor markers in the early diagnosis of recurrence in gynecologic neoplasms: combined determination of CA-125, CA 15-3, CA 72.4, SCC, 90 K].

In 156 patients with gynecologic neoplasia the sieric levels of tumor markers (CA 125, CA 15-3, CA 72.4, SCC and 90 K) before the primary treatment and during the follow-up have been evaluated. In the patients with ovarian cancer elevated levels of CA 125 (80%), CA 72.4 (62%), 90 K (49%) and CA 15-3 (16.6) were found. The integrated evaluation of CA 125 and 90 K sieric levels was positive in the 86% of cases. The evaluation of CA 125 in combination with 90 K seems to facilitate the earlier detection of ovarian cancer recurrences. Elevated levels of SCC (89%) were found in the patients with cervical cancer. In the patients with endometrial or vulvar cancer the evaluation of these tumor markers was not significant.

Antigens, Neoplasm↗
PubMedDate not supplied

[Intracellular potassium in normal and pathological pregnancy. I. Regulation of transport and concentration].

Potassium is the most represented intracellular cation. Its concentration is regulated by active and passive mechanisms: cellular capacity, diffusion, channels and active transport. The relationships among Potassium and other cell cations may be involved in the pregnancy adaptation, and in the pathogenesis of some diseases, among which hypertension and diabetes.

Body Fluids↗