[Intra-abdominal radiocolloid administration: indications, complications, results].
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Brachytherapy↗
Biomedical subjects
H Vahrson
Publications and source records attributed to H Vahrson.
[Primary cancer of Bartholin's gland].
Carcinoma of Bartholin's gland is an extremely rare tumour representing approximately between 1% and 7% of the cases of cancer of the vulva. The aetiology of the tumour, which can be subdivided by means of light microscopy into squamous cell carcinoma, adenocarcinoma, adenoid cystic carcinoma and adenoacanthoma, remains unknown. Surgical and radiotherapeutic treatment is possible also in combination. If primary operative therapy is chosen, inguinal lymphadenectomy is required as usually suggested in all cases of cancer of the vulva; the metastatic involvement of the inguinal lymph nodes is regarded as the main prognostic determinant: if only one inguinal node has microscopic metastases, a five-year survival rate between 60% and 70% can be achieved in a selected operative group of patients. If more than four positive groin nodes are histologically diagnosed the survival rate - according to current results, not subdivided into different alternatives of therapy - is below 20%.
Adenocarcinoma↗
[Hysterography with afterloading-applicator in place. A simple method for improving the treatment planning of uterine cancer].
Anatomical configurations often are an obstacle to a convenient dose-distribution in intracavitary afterloading irradiation. Multiple applicators (splay applicators, twin applicators) cannot be introduced in all cases because of the necessary cervix dilatation. In several cases can be demonstrated, that a defined intracavitary irradiation is possible only by hysterographic control of the intrauterine position of the applicator. By this control generally a mono-applicator is sufficient, which can be placed according the anatomy of the uterine cavity in each session. For this purpose a simple hysterographic method with applicator in position is demonstrated, which requires only few additional effort during intracavitary irradiation.
Aged↗
Cyclophosphamide-induced immune thrombocytopenia in a patient with ovarian carcinoma successfully treated with intravenous gamma globulin.
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Cyclophosphamide↗
[After care of ovarian carcinoma from gynecologic viewpoint].
A co-operation between the different institutions and doctors and the tumor centre is indispensable for an adequate follow-up of the ovarial carcinoma. Besides diagnosis and therapy of side effects of the treatment as well as early diagnosis of recurrences, a psychical and social care is particularly necessary. The follow-up treatment aims at a full social rehabilitation of probably cured patients and, in case of incurable patients, at a relief of pain until death. The determination of t-RNA as a reliable tumor marker and the examinations necessary for routine controls (minimal and maximal programme) are indicated.
Aftercare↗
[Recent trends in the therapy of vaginal carcinoma].
The presented paper gives a historic review of the change from the contact therapy to the percutaneous irradiation. The dominating role of radiotherapy compared to surgery is pointed out. With the help of therapeutic planning in Giessen an aimed pendulum irradiation, a high-volume percutaneous irradiation, a modern high-intensity afterloading system (Buchler), and an interstitial therapy are reported. Recently published important cure rates are shown in a table. The 5-year survival rate of 78 patients in Giessen from 1957-1975 was 42.3%. The discussion concentrates on the tolerance dose of the vagina according to the different dose rates and fractionations.
Brachytherapy↗
Time-dependent changes of plasma ribonuclease activity in female Wistar rats under combination therapy of ovarian carcinoma.
Determinations of plasma ribonuclease were recommended in 1977 by Sheid et al. for laboratory diagnosis of ovarian carcinoma. We investigated the turnover of transfer ribonucleic acid (tRNA) as the substrate of the enzyme in healthy female inbred rats under the multistep-massive dose therapy of ovarian carcinoma usual at the Department of Gynecology, University of Giessen. Whereas mitopodozide, percutaneous irradiation of the abdomen and teniposide did not have any detectable influence on the enzyme activity, the enzyme was strongly suppressed by the other therapy steps: minima of tRNA turnover were observed on the 2nd day with adriamycine, on the 4th day with methotrexate and methotrexate/folinic acid, on the 6th day with cyclophosphamide and fractionated percutaneous irradiation with cyclophosphamide medication in the intervening periods. According to the results, a plasma ribonuclease determination to check the result of therapy should only be performed at an interval of 2 weeks after each therapy step.
Animals↗
alpha-Fetoprotein, carcinoembryonic antigen, human chorionic gonadotropin and its beta subunit in metastatic choriocarcinoma: short-term follow-up and determinations of resistance during chemotherapy.
Serum levels of alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), human chorionic gonadotropin (hCG) and its beta subunit (beta-hCG) were measured during the therapy of a choriocarcinoma with lung metastases. All AFP determinations were in the normal range. The CEA levels showed a correlation with the radiologically confirmed development of lung metastases. A rise of hCG during the first 2--6 days to 177.3--407.5% of the initial level and a descent to 17.9--33.7% of the initial level at the 10th day of therapy were typical behavioral patterns associated with tumor sensitivity. The onset of tumor resistance against the chemotherapeutic preparation used was evident within 10 days after therapy. A small rise, a slight fall below the initial value, and then a rapid increase to above the initial level were typical parameters. With established tumor resistance there was an autonomous unremitting increase of hCG activity. Short-term follow-up to hCG in intervals of 2 days at least for over a period of 10 days are deemed advisable for early detection of resistance toward the particular chemotherapeutic preparation used.
Adult↗
[Effect of colloidal 198Au on cell cultures of human tumors (author's transl)].
The authors observed the effect of colloidal 198Au on the morphology of cells in 19 cell cultures of human tumors. Partly, there were typical modifications. The reactions of the individual cells were different and the radiosensibility and dependence on the dose seemed to vary with different concentrations of the radiogold. The importance of this study with regard to clinical problems is discussed.
Cells, Cultured↗
[The behavior of tumor cells of female genital carcinomas in vitro under irradiation with different activities of radiogold (author's transl)].
A method is reported which permits an assessment of the effect of radiation, especially with 198Au, upon primary cultures. Thus, a statement of the individual radiation sensitivity of a tumor can be made, which is not possible with conventional methods. The tumors investigated by us exhibited a dependence of their cells in vitro upon the activity of the radiogold, and different tumors revealed a different radiosensitivity to the same dose.
Cells, Cultured↗
[Alterations of the plasma ribonuclease activity in female wistar rats under the conditions of combined therapy of the ovary carcinoma (author's transl)].
The authors have analysed the influence exercised by the combined therapy of the ovary carcinoma on the plasma ribonuclease activity in Wistar rats. The medicaments "Proresid", "VM-26", and "Methotrexat" together with a percutaneous irradiation of the abdomen did not alterate perceptibly the enzyme activity during the experiment, but there was a considerable reduction of the enzyme activity after an application of "Endoxan", "Adriblastin" and "Methotrexat" with subsequent administration of "Leukovorin". The most violent ribonuclease suppression, however, was obtained by an intraperitoneal instillation of radiogold and a fractioned percutaneous irradiation of the abdomen with intercalated administration of "Endoxan".
Animals↗
[Determination of the plasma ribonuclease activity as a diagnostic aid in the diagnosis of ovarian cancer. Results of a double blind study (author's transl)].
The determination of the plasmaribonucleases was reported by Sheid and co-workers in 1977 for the diagnosis of carcinoma of the ovary. The authors investigated the accuracy of this test with a modified method in a double blind study encompassing healthy controls. Blood samples from 62 patients with ovarian cancer were tested. The results were accurate in 56 cases. In 6 cases the test results were doubtful. The difference in the ribonuclease activity was significant between patients with ovarian cancer and healthy patients or patients in remission from ovarian cancer. The results were not dependant upon the FIGO staging of the disease. Our results encourage the recommendation to use this test as a diagnostic aid in carcinoma of the ovary.
Clinical Enzyme Tests↗
[The toxicity of massive dosis of VM26 (4-demethyl-epipodophyllotoxin-beta-D-thenylidene glucoside). A contribution to the therapy of advanced ovarian cancer (author's transl)].
19 patients with advanced ovarian cancer (FIGO-stages IIb-IV) were treated by ultra-high doses of VM26 partly according to positive oncobiograms during Multiple-drug-stoss-therapy. The toxic reactions and the cytostatic effect were investigated. The range of 57,9% remissions and the moderate toxicity suggest a specific application of VM26 in advanced ovarian cancer.
Aged↗
[Sensitivity testing of cytostatic agents for gynecologic tumors based on cytologic and autoradiographic evaluations (proceedings)].
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Antineoplastic Agents↗
Antibacterial activity of amniotic fluid against Staphylococcus aureus, Candida albicans and Brucella abortus.
Sixty amniotic fluid samples from sixty patients between 14--42 weeks gestation were studied for antibacterial activity against Staphylococcus aureus, Brucella abortus and antifungal activity against Candida albicans. Both antibacterial and antifungal activity of the amniotic fluid were observed. When antimicrobial activity was correlated with gestational age, it was found to increase with the period of gestation. Maximum antimicrobial activity of the amniotic fluid was found to be present in the samples obtained between 36--42 weeks of gestation. All samples before 20 weeks gestation showed week antibacterial activity against Staphylococcus aureus, but comparatively strong reaction against Candida albicans and Brucella abortus.
Amniocentesis↗
[Combined therapy of ovarian cancer (author's transl].
Following the introduction of massive triple drug therapy with high doses of Endoxan, Proresid and Methotrexat instead of the earlier long-term Endoxan treatment in addition of surgery, percutaneous irradiation and intraperitoneal radio-gold, 3 year survival of advanced stages IIb-IV of ovarian carcinoma rose from 19.6% to 42.6%. The 3 year survival of all malignant ovarian tumors (primary or secondary) rose from 38.3% to 51.0%. Further development led to targeted multiple drug therapy (ultrahigh Endoxan, Proresid/VM26, Methotrexat and Adriblastin) according to oncobiogram. The main side-effects, their control and experience with combined chemotherapy and irradiation are described.
Cyclophosphamide↗
[Preliminary report on the treatment of ovarian cancer with adriamycin following full conventional treatment (author's transl)].
In 22 cases with advanced ovarian cancer, chemotherapy with Adriamycin was employed. All patients had previous operation, triple drug pulsechemotherapy, intraperitoneal radioactive gold instillations and external radiation. A remission was achieved in 36.4% of the patients. The side effects and complication of treatment with Adriamycin are reported and discussed.
Adolescent↗
[The diagnosis and removal of obscure intrauterine devices (author's transl)].
When the thread of an intrauterine device cannot be seen in the cervical canal a diagnostic procedure to insure continued contraceptive effectiveness is mandatory. Hysteroscopy is the method of choice for localization of an intrauterine device even during pregnancy. Hysteroscopic removal is possible even during pregnancy. With this method we removed 16 obscure intrauterine devices and 7 devices during pregnancy. The advantages and disadvantages of other diagnostic and therapeutic methods are discussed.
Adult↗