Metastasising gliomas in young subjects.
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Biomedical subjects
Publications and source records attributed to H Urich.
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The occurrence of malignant gliomas in a pair of identical twins is reported. One, in the posterior fossa, presented in the third year of life, the other, in the left cerebral hemisphere, in the eighth. Both ran a rapidly progressive course and died within a few months of the onset of symptoms. The histological structure of the gliomas was similar and both tumours consisted of astrocytic and oligodendroglial parts. Review of the literature revealed only two pairs of histologically proven gliomas occurring in identical twins. The number of cases reported is too small for any valid conclusions on possible genetic mechanisms.
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A man aged 59 years developed a rapidly progressive muscular weakness which within a few weeks involved almost the entire musculature. A carcinoma of the stomach was discovered at necropsy. The skeletal muscles showed widespread necrosis with minimal inflammatory reaction. The findings are compared with those in a woman of 51 with Hashimoto's thyroiditis who developed a slowly progressive weakness of her trunk muscles which after some months began to involve the limbs. Post-mortem examination revealed typical polymyositis with massive inflammatory infiltration and limited necrosis of muscle. We conclude that these two types of muscle disease are morphologically, and probably pathogenetically, different.
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