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Sixty-three patients with nongonococcal urethritis were enrolled in an open, comparative study and assigned to 14 days of treatment with tosufloxacin 150 mg orally three times daily or doxycycline 100 mg orally twice daily. Chlamydia trachomatis was detected in 27 (42.9%) of the 63 patients: 13 (43.3%) of the 30 tosufloxacin-treated patients and 14 (42.4%) of the 33 doxycycline-treated patients. The clinical response between the two treatment groups was compared 7, 14, and 21 days after initiation of therapy. Clinical response to tosufloxacin was as good as that seen with doxycycline at the three follow-up visits. All C trachomatis-positive patients at baseline tested negative in both treatment groups at the three follow-up visits. Adverse reactions were observed in two patients treated with doxycycline. Although the number of study patients was small and the follow-up period short, these results indicate that tosufloxacin and doxycycline are equally effective in the treatment of nongonococcal urethritis.

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