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Biomedical subjects

H Ullrich

Publications and source records attributed to H Ullrich.

At least 55 records · Page 3Linked to original sources
PubMed1982

Quantitative investigation on the urinary excretion and metabolism of 3,4-dimethoxyphenylethylamine in schizophrenics and normal individuals.

A quantitative method for the detection of DMPEA in urine was developed. It is based on the fluorometric determination of DMPEA in the form of its phosphopyridoxyl derivate. The limit of detection is 2 microgram DMPEA per 1 g creatinine. The DMPEA content was measured in urine from healthy persons, from schizophrenics, and from psychiatric patients without schizophrenia hospitalized with the schizophrenics. From each person five to ten 24-hr urine samples were investigated. DMPEA could be found neither in schizophrenics nor in controls or healthy persons. Finally, the urinary excretion of parenterally applied 14C-DMPEA was determined in three healthy volunteers and in three rats. In man about 25% of the label was excreted as DMPEA. The main metabolite in urine was homoveratric acid. Both compounds were excreted as conjugates.

Biotransformation↗
PubMed1980

[Experimental coronary atherosclerosis and ischemic heart disease (author's transl)].

Experimental coronary atherosclerosis was produced by application of 2 g cholesterol per day per animal to 20 rabbits for different periods (12, 16 and 20 weeks); 5 animals were used as controls. Histological sections of the basal part of the left heart ventricle were investigated morphometrically. The frequency of the atheromatosis, their distribution, and the extension of the average narrowing of the vessels were determined separately for subepicardial and intramural coronary arteries. Contrasting to the subepicardial arteries, the intramural coronary arteries showed severe lesions of the vessel wall with narrowing and obturating processes. Thereby, a time-dependent progression of the frequency and severity of atheromatosis was noted. The narrowing of the lumen as regards to the subepicardial coronary arteries did not differ significantly from controls. The intramural coronary arteries, on the other hand, showed a progressive and of the lumen at all periods of investigation significant narrowing.

Animals↗