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Biomedical subjects

H Uematsu

Publications and source records attributed to H Uematsu.

At least 73 records · Page 4Linked to original sources
PubMed1988

Ramified pelves and their blood supply of the horseshoe kidney in 2 Japanese.

Gross anatomy of the horseshoe kidney in 2 Japanese patients clarified that the long renal pelvis consists of 4 funnel-shaped tubes (Pelvis renalis ramificata) in the hilus opening in the ventral direction, and that the 4th tube can drain half of the isthmus. The renal artery, on the other hand, divided into 2 dorsal and ventral branches around the long pelvis in the hilus, the latter of which gave rise to the branches to the first and second tubes, but the former the branch to the third. Another artery arose from the lower portion of the abdominal aorta to supply the 4th tube in the half of the isthmus. This method of blood supply was principally in good accordance with that described by Graves (1971) except for a branch from the inferior mesenteric artery to the isthmus. These pelvic ramification and pattern of blood distribution were summarized in Fig. 9.

Aged↗
PubMed1987

Non-linear pharmacokinetics of aprindine hydrochloride in oral administration.

The pharmacokinetics of oral aprindine hydrochloride (in the following briefly called aprindine; Aspenon) were studied in 38 patients with ventricular premature contractions following single or multiple administration. Oral administration of aprindine in a single dose of 100-150 mg resulted in a mean maximal plasma concentration of 0.77 microgram/ml and a mean elimination half-life of 26.5 h. With multiple oral administration in 10 mg and 20 mg doses at intervals of 8 h, plasma concentration reached a steady state in 1-2 weeks with either dosage rate. Stable plasma concentrations were maintained with little diurnal or day-to-day fluctuation. The mean steady-state minimal plasma concentration with a 10 mg dosage was 0.28 microgram/ml. With a 20 mg dosage, however, this was more than tripled to 0.89 microgram/ml. The elimination process after the final administration of the drug was slower than with single dosage, and deviated from the first-order kinetics to produce a convex curve on a semilogarithmic graph paper. From these results it was apparent that aprindine shows non-linear pharmacokinetic behavior within the therapeutic dosage range.

Administration, Oral↗