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Biomedical subjects

H Turndorf

Publications and source records attributed to H Turndorf.

At least 199 records · Page 11Linked to original sources
PubMed1963

The value of the preoperative visit by an anesthetist. A study of doctor-patient rapport.

The psychologic effect of the preoperative visit by an anesthetist has been compared with the effect of pentabarbital for preanesthetic medication. Patients receiving pentobarbital 1 hour before an operation became drowsy but it could not be shown that they became calm. Patients who had received a visit by an anesthetist before operation (informing them about the events which were to occur on the day of the operation and about the anesthetic to be administered) were not drowsy but were more likely to be calm on the day of the operation. The importance of the preoperative visit probably explains, in part, the difficulties previous investigators have had in showing sedative effects from barbiturates and narcotics before operation. The tremendous emotional significance to a patient of illness or an operation may explain why physicians are able to exert such influence upon their patients.

Anesthesiology↗
PubMedDate not supplied

Pavlovian fear conditioning in mice anesthetized with halothane.

Pavlovian fear conditioning was employed to investigate learning during general anesthesia. Mice were given three CS-UCS presentations while anesthetized with halothane. The CS was a 10-s tone and the UCS a 0.4-mA shock delivered intramuscularly to the hindlimbs via needle electrodes. Anesthetized control groups received either CS only, UCS only, or CS followed by a 3-min delayed UCS. Strength of fear conditioning was assessed by measuring duration of suppression of drinking induced by tone presentation in a test session conducted 24 h after training. Results showed that mice trained under anesthesia exhibited a significant amount of conditioned suppression relative to the anesthetized control groups. These results show that Pavlovian fear conditioning can occur under halothane anesthesia.

Acoustic Stimulation↗
PubMedDate not supplied

Anesthetic care of a patient with an intracranial hemorrhage after thrombolytic therapy.

Thrombolytic therapy is being used with increasing frequency to treat acute myocardial infarction (MI). It is important for both the general and cardiac anesthesiologist to understand the effects of thrombolysis on hemostasis and myocardial function, since these patients can present for emergent surgery in the cardiac or general operating theater. The authors report a case of a patient who developed an intracranial hemorrhage following thrombolytic therapy that required emergency surgical intervention.

Anesthesia, Intravenous↗
PubMedDate not supplied

Comparison of cardiotropic drug effects on haemodynamic and myocardial energetics in patients with heart failure: a computer simulation.

The purpose of our study is to compare haemodynamic responses and the ischaemic potential of commonly used inotropes (dopamine, dobutamine and milrinone) using a computer model of the cardiovascular system. Cardiotropic drugs interact with the model by changing ventricular elastance and resistance of the individual circulation. All three drugs increase cardiac index in a dose-dependent manner. Dopamine at medium and high infusion rates increases heart rate, systemic vascular resistance and arterial blood pressure. The associated increase in coronary blood flow, however, is not sufficient to account for increased oxygen demand. Both dobutamine and milrinone decrease vascular resistance and increase coronary blood flow. The more pronounced increase in heart rate associated with dobutamine, however, results in a higher ischaemic potential for this drug. Our simulation demonstrates that although all the drugs studied improve cardiac function in simulated patients with heart failure, milrinone accomplishes this at a lower energy cost. The computer simulation developed can be used to assess the complex effect of cardiotropic drugs and possibly suggest optimal drug therapy in specific clinical situations.

Cardiotonic Agents↗
PubMedDate not supplied

Faulty anesthesia circuits: a source of environmental pollution in the operating room.

Commonly used disposable anesthesia circuits were studied for leak and gas spillage. Trace anesthetic gas concentrations produced by these circuits in the anesthesiologist's breathing zone were analyzed by a Hewlett-Packard Gas Chromatograph. These measurements demonstrated ambient halothane (3.29 +/- 0.1 ppm) and N2O (333.5 +/- 2.31 ppm) concentrations well above target levels, when swivel-type disposable anesthesia circuits were used, despite the presence of standard gas-scavenging devices and appropriate operating room fresh air exchange rates. Lower ambient concentration levels (0.38 +/- 0.03 ppm halothane and 31.3 +/- 1.49 ppm N2O) were measured when Y-type disposable anesthesia circuits were used.

Air↗
PubMedDate not supplied

Rebreathing characteristics of the Bain anesthesia circuit.

The humidity output and CO2 elimination of the Bain circuit were tested on a simulated adult patient. The moisture content of inspired gases was found to be adequate when the circuit was used with a minute volume of 8.4 L/min and a fresh gas inflow of 4.9 L/min (65 percent relative humidity at room temperature at the onset of experimentation, rising to 100 percent after 80 minutes). However, the mean inspired CO2 concentration increased from 0.8 percent to 5.5 percent when the fresh gas inflow was decreased from 8 L/min to 3.5 L/min. It is recommended, therefore, that the circuit should not be used for long periods of time without measuring arterial CO2 tension or in situations where intentional hypocarbia is desired.

Adult↗
PubMedDate not supplied

Intermittent exposure to 40 percent oxygen prolongs rat survival in 100 percent oxygen.

Prior intermittent exposure to 40 percent O2 protected rats against fatal O2 toxicity. Protection was not absolute, however, for the death of most rats in 100 percent O2 was not prevented but delayed considerably. Furthermore, those rats which did survive exposure to 100 percent O2 for long periods by virtue of prior-adaptation to increased O2 concentrations had pathologic changes in the lungs typical of chronic O2 toxicity. The very early demise of some rats indicated that 1 of 12 animals is hypersenstiive to high concentrations of inspired O2.

Adaptation, Physiological↗