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Biomedical subjects

H Tsurushima

Publications and source records attributed to H Tsurushima.

34 records · Page 2Linked to original sources
PubMed1996

[FLAIR images of cerebral and brain stem infarction].

FLAIR (fluid-attenuated inversion recovery) images are MR images obtained with an inversion recovery sequence having a long inversion time (TI) and a long echo time (TE). We examined 47 cases (56 graphics) of lacunar infarction (LI), 28 cases (32 graphics) of cortical infarction (CI) and 16 cases (23 graphics) of stem infarction (SI) with a FLAIR sequence having a repetitive time (TR) of 6500 msec, a TI of 1700 msec and a TE of 110 msec, and compared these graphics with T2-weighted images by spin-echo sequence (TR 2500 msec, TE 90 msec). LI and CI were better demonstrated with FLAIR images than with conventional T2-weighted images. FLAIR images were very useful in detecting lesions adjacent to the lateral ventricles and the cerebral sulci in particular, because the cerebrospinal fluid signals in the lateral ventricles and the cerebral sulci were low-intensity, with brain tissue appearing as high-intensity areas. In a number of old infarctions, FLAIR images revealed cystic structures, constructed out of internal low-intensity areas and peripheral high-intensity areas. These structural changes suggested that FLAIR images can provide information on pathological changes.

Aged↗
PubMed1995

Multiple arteriovenous malformations of spinal cord and brain in a child.

A case of concurrent intracranial and spinal cord arteriovenous malformations (AVMs) is described. A 3-year-old girl presented with paraparesis, bladder-bowel disturbances and bilateral dysesthesia of the lower extremities due to a spinal hematoma, resulting from a spinal AVM. Magnetic resonance imaging revealed a hematoma and abnormal vessels in the spinal cord. The AVM was embolized with polyvinyl alcohol particles and silk sutures and was surgically removed. Later, this girl presented with disturbance of consciousness due to an intraventricular hemorrhage, resulting from a cerebral AVM. The cerebral AVM was surgically resected. The coexistence of bleeding cerebral and spinal AVMs is very rare.

Angiography, Digital Subtraction↗
PubMed1995

[Low incidence of point mutation of N-ras oncogene in human gliomas].

We examined the incidence of point mutations in codon 12 and 61 of N-ras gene in human gliomas using PCR with mismatched primers. This method detects point mutations. PCR with mismatched primers induced restriction sites in normal DNA but not in mutational DNA. Genomic DNAs were extracted from paraffin-embedded tissues and were amplified with nested PCR. Among 17 cases, point mutation has not been able to be found so far, when examined in codon 12 of N-ras gene and among 10 cases in codon 61 of N-ras gene. It can thus be said that point mutational activation of N-ras oncogene is an uncommon event in human gliomas.

Base Sequence↗
PubMed1995

Nuclear characterization and G2M ploidy in human brain tumors using semiautomated image analysis.

We used image analysis to study nuclear morphometry and DNA content in relation to time to tumor progression in a series of 88 patients with brain tumors. Clinical follow-up was obtained for 73 patients. The patients with diploid tumors had a longer time to tumor progression than those with triploid, tetraploid, or hypertetraploid tumors. Mean SG2M-DNA indices (DIs) increased significantly with a increase in mean DIs in all tumors. The mean DIs appeared to be dependent on the number of SG2M phase cells. We conclude that tumors with hypertetraploid in G2M ploidy are highly malignant. Those tumor cells have a large nuclear size, much deformity in nuclear shape, and great proliferative potential. The G2M-tetraploid tumors showed a shorter time to tumor progression when the number of SG2M fractions was large. In contrast, the G2M-hypotetraploid tumors showed a longer time to tumor progression in comparison with other tetraploid and hypertetraploid tumors, but the difference was not significant.

Aneuploidy↗
PubMed1993

Expression of tenascin and BDNF during the migration and differentiation of grafted Purkinje and granule cells in the adult rat cerebellum.

It is believed that 'cell-adhesion molecules' and neurotrophic factors play important roles in the host-graft interactions during the reconstruction of injured brain by neural transplantation. In this study, we have examined the expression of such molecules and factors during the migration and differentiation of grafted Purkinje and granule cells in the adult rat cerebellum. Cerebellar primordium at the 14th gestational day (E14) was transplanted into adult rat cerebellum. Purkinje cells which had migrated from the grafted tissue into the host molecular layer were identified immunohistochemically with a specific marker, anti-spot 35 antibody, as well as by labeling them with bromodeoxyuridine (BrdU) during their final mitotic period. In the grafted site, transient expression of a neuron-glia cell adhesion molecule, tenascin, was detected immunohistochemically. This molecule was expressed transiently in the host tissue adjacent to the migratory Purkinje cells, as well as within the grafted tissue. Tenascin was not detected in intact host tissue apart from the grafted tissue. In the light of tenascin expression in the migratory process of Purkinje and granule cells during cerebellar development, the induction of this molecule in the host tissue might be involved in the migration of grafted Purkinje and granule cells. Furthermore, gene expression of brain-derived neurotrophic factor (BDNF) was found by in situ hybridization and the expression of NGF receptor was found immunohistochemically in the areas where grafted Purkinje and granule cells developed. These findings suggest the involvement of the neurotrophic factor in the growth and differentiation of the grafted cerebellar primordium.

Animals↗
PubMed1993

[Migration of donor Purkinje cells in the host adult rat cerebellum].

It is considered that cell adhesion molecules play important roles in the host-graft interaction during the reconstruction of the injured nervous system by neural transplantation. In this article, we report the expression of such molecules during the migration and differentiation of donor Purkinje cells in the adult rat cerebellum. Cerebellar primordium at the 14th day of gestation was transplanted into the adult rat cerebellum. Purkinje cells which had migrated from the grafted tissue into the host molecular layer were identified immunohistochemically with anti-spot 35 antibody, a specific marker for Purkinje cells in the cerebellum, as well as by labeling them with bromodeoxyuridine at their final mitotic period. In the grafted site, transient expression of a neuron-glia cell adhesion molecule, tenascin, was detected immunohistochemically. This molecule was expressed in the host tissue adjacent to the migratory Purkinje cells as well as within the donor immature tissue. Tenascin was not detected in the host tissue far distant from the grafted tissue. In considering the expression of tenascin in the migratory process of Purkinje cells during cerebellar development, this molecule induced in the host tissue may be involved in the migration of donor Purkinje cells.

Animals↗
PubMed1992

Morphometrical analysis of GFAP-positive cells in human astrocytomas.

The morphometrical characteristics of human astrocytoma were examined using the shape, size, and intercellular distances of glial fibrillary acidic protein-positive cells in samples from 21 patients with various astrocytomas and normal samples resected during operations on seven patients with other brain tumors. The results showed that astrocytoma cells were rounder than normal astrocytes with fewer processes. Low-grade astrocytomas were smaller than astrocytes or rapid regrowth astrocytomas. Morphological analysis of astrocytoma may be valuable for evaluating the potential migration to adjacent tissue.

Adult↗
PubMed1991

Normal brain damage after radiotherapy of brain tumours.

A total of 106 patients were examined for adverse effects to the brain from 60Co or proton radiotherapy. Radiation induced change (RIC) developed within the irradiated field 40-60 months after doses of 800-1000 neuNSD or 70 TDF and in 10-20 months after doses of more than 1700 neuNSD or 100 TDF. The incidence of RIC increased significantly with increasing age. Furthermore pathological changes like oedema and infarction in the brain tissue may be an important factor for the development of RIC in the central nervous system (CNS).

Adult↗
PubMed1991

[Posterior interosseous nerve paralysis caused by ganglion: a case report].

A 63-year-old man presented with a posterior interosseous nerve palsy secondary to a ganglion compressing the nerve against the arcade of Frohse. Decompression and neurolysis resulted in full functional recovery. While patients with the so-called classic "Saturday night palsy" or even patients with a radial nerve palsy secondary to a fractured humerus may be expected to recover completely without surgery, early surgery is the conservative approach in patients with a nerve palsy secondary to the mass. However it is difficult to diagnose the nerve palsy secondary to the small mass. The treatment for patients with a progressive nerve palsy of unknown origin must be given attention.

Fingers↗
PubMed1991

[A case of epidural hematoma due to dural metastasis].

A case of epidural hematoma due to dural metastasis is reported. A 62-year-old man was admitted to our hospital with generalized convulsion. A month prior, he underwent a tumor-removal operation for dural metastasis of lung cancer. CT scan on admission showed an epidural hematoma at the left frontal region. At operation, the epidural hematoma and dural invasion of neoplasm was found and removed. Pathological examination revealed dural metastasis of the poorly differentiated adenocarcinoma. According to the literature, intracranial metastasis of a bronchogenic carcinoma bleeds more often than that of other carcinomas. The particular vascular invasiveness of the neoplasm or a hemorrhagic diathesis is considered as the cause of the hemorrhage. In the present case the pathogenesis of the hemorrhage was thought to be the hypervascularity of the rapid growth tumor, fragility of the tumor vessels, and invasiveness of the tumor into the dural vessels. Adding to these, two other factors could play an important role in forming epidural hematoma; 1) the tumor existed mainly in the epidural surface and 2) dural adhesion of the cranial bone was not so tight.

Adenocarcinoma↗
PubMed1990

Magnetic resonance imaging of spinal cord injury without radiologic abnormality.

A 3-year-old girl with spinal cord injury without radiologic abnormality (SCIWORA) is reported. Magnetic resonance imaging (MRI) showed an abnormal intensity of the spinal cord at the level of C7 to Th1 in the acute stage and severe atrophic change in the chronic stage. This is the first report of SCIWORA with positive diagnostic imaging. The mechanism of SCIWORA is discussed based on the positive MRI findings.

Child, Preschool↗
PubMed1990

[Intraoperative evaluation of carotid endarterectomy with electromagnetic flowmetry and portable DSA].

In order to perform carotid endarterectomy more safely, we have evaluated, intraoperatively, the result of an operation with electromagnetic flowmeter and portable digital subtraction angiography (DSA). During surgery, flow of the exposed internal and common carotid artery was measured with an electromagnetic flowmeter, before and after endarterectomy. After the closure of the arteriotomy, portable DSA was carried out by injecting contrast medium from the common carotid artery. Our simple portable DSA system consists of a surgical X-ray television set, image processor (Sigma X) and still video-recorder. This system almost gives us a real-time presentation of a subtracted view of angiography. There were twenty patients including one patient with major stroke, 14 with minor stroke, three with transient ischemic attack, and two asymptomatic patients. Increase of the flow through the internal carotid artery was documented with an electromagnetic flow-meter in 13 of 20 patients following endarterectomy. Flow reduction was seen in two patients, one of whom was found to have an intimal flap from residual plaque visualized in the portable DSA. The plaque was removed by reopening the artery. Among twenty patients, intraoperative portable DSA showed an intimal flap in three patients and a step in four patients. Although the incidence of abnormal findings was high, degree of abnormality was not severe enough to reopen the artery except in one case. The purposes of carotid endarterectomy is two-fold. It is used for the removal of the plaques which can be a source of emboli, and also for the augmentation of flow in the narrowed segment of the artery.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1990

Suprasellar ectopic pituitary adenoma: case report and review of the literature.

The occurrence of a totally suprasellar ectopic pituitary adenoma in a 71-year-old man is described. The tumor was attached to the pituitary stalk, extending upward toward the third ventricle. No intrasellar lesion was observed. Histological examination revealed a pituitary adenoma with large numbers of eosinophilic cells with moderate nuclear polymorphism and rare mitosis. Immunohistochemical staining revealed that the tumor cells were strongly positive for anti-adrenocorticotropic hormone antibody. A review of five previously reported intracranial ectopic pituitary adenomas revealed that two were silent corticotropic tumors and two occurred with Cushing's syndrome.

Adenoma↗
PubMed1990

[Demonstration of a vascular lesion by intraoperative portable DSA in a case of intracerebral hematoma with impending herniation].

A nine year old boy with sudden onset of loss of consciousness was brought to the emergency room where he was in deep coma with bilateral decerebrated rigidity, and fixed dilated pupils. Computerized tomographic scan showed an intracerebral hematoma in the left temporal lobe associated with signs of uncal herniation. He was taken to the operating room immediately and craniotomy was started. After aspirating a small amount of hematoma through a burr hole, left carotid angiography was carried out by using a portable digital subtraction angiography (DSA) unit. The procedure took approximately ten minutes, and it showed arteriovenous malformation (AVM) supplied by a temporal branch of the middle cerebral artery. Using this angiogram as a guide, the intracerebral hematoma and the AVM were completely removed. The patient recovered well and returned to school after rehabilitation. This case illustrates a method of treatment for intracerebral hematoma with impending herniation. Although, in general, preoperative angiography is required before the operation of AVM, it could be argued that time spent for angiography may result in irreversible damage to the brain stem in the presence of uncal herniation. We chose to perform intraoperative portable DSA during evacuation of the hematoma instead of wasting time on preoperative angiography. With this method, we were not only able to remove the hematoma without delay, but were also able to extirpate the AVM safely. Whether or not our method can be used in general remains to be seen, and further experience is required.

Angiography, Digital Subtraction↗