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Biomedical subjects

H Tsur

Publications and source records attributed to H Tsur.

At least 73 records · Page 4Linked to original sources

Urethral stricture following indwelling catheter in hypospadias repair.

We report 2 patients who were operated on for hypospadias in whom severe dysuria developed several weeks after the removal of a Foley catheter, which had been in place for two and eight days, respectively. Distal urethral narrowing was diagnosed by endoscopy and by micturating cystourethrography. Since we believe the urethral stricture was caused by the indwelling catheter, we now use cystotomy for urinary diversion in all patients operated on for hypospadias.

Catheterization↗

Epithelioid sarcoma of the hand.

A case of epithelioid sarcoma in a young man is described. At 16 years of age the patient had two skin ulcers removed from his hand, which were diagnosed as synovial sarcoma. At 21 years he underwent wide excision of the same area, including part of the thenar muscle, and a diagnosis was made of palmar fibromatosis with no confirmation of malignancy. Histological examination of biopsied growths three years later at age 24 showed the typical picture of epithelioid sarcoma. Following further excisions of local recurrences and removal of half the distal part of the forearm, the patient agreed to below-elbow amputation at age 27. He died within the year. The case presents the typical features of epithelioid sarcoma: apparently benign presentation on the hand in a yound man, a histological picture resembling other diseases resulting in misdiagnosis early in the disease, and local recurrences and metastasis. The misleading clinical and histological pictures of this insidious disease are discussed.

Adolescent↗

Thermoregulatory responses of patients with extensive healed burns.

Two groups (A, n = 4; B, n = 6) of young male subjects with deep second- and third-degree healed burns (burned area: 48.6 +/- 3.6 and 23.7 +/- 3.1% of the total skin surface area in groups A and B, respectively) and a group of healthy subjects (C, n = 10) underwent a 3-h exposure to 40 degrees C, 50% rh, stepping on a bench 32 cm high, at a rate of 12 steps/min (Vo2 = 1.05 +/- 0.06 l X min-1). Rectal temperature (Tre), mean skin temperature (Tsk), and heart rate (HR) of group A were significantly higher than those of groups B and C; i.e., at the end of the 1st h Tre was 38.7, 37.9, and 37.7 degrees C; Tsk was 37.3, 36.4, and 37.0 degrees C; HR was 151, 105, and 110 beats X min-1 in groups A, B and C respectively. Maximal evaporative cooling capacity (Emax) was 4.9 +/- 0.1, 7.2 +/- 0.5, and 10.2 +/- 0.4 W X kg-1 in groups A, B and C, respectively, while the required evaporation capacity for thermoequilibrium (Ereq) was similar in all groups (6.7 +/- 0.1, 6.8 +/- 0.1, and 6.6 +/- 0.1 W X kg-1). Total sweat rate (msw) was 594 +/- 13, 602 +/- 29, and 485 +/- 34 g X h-1 in groups A, B and C, respectively, msw normalized to healthy skin area (msw/AH) was 671 +/- 75, 449 +/- 29, and 280 +/- 16 g X h-1 X m-2 in groups A, B and C, respectively. Sweating sensitivity normalized to healthy skin area (msw/AH X delta Tre) was similar in all three groups. It is suggested that the similarity between groups B and C can be explained by the compensatory sweating from the healthy skin of group B, which was sufficient because Emax greater than Ereq. In group A, Emax less than Ereq; therefore thermoequilibrium could not be maintained despite high compensatory sweat rate from the healthy skin. The similarity in msw/AH X delta Tre supports the assumption that elevation in Tre is the main drive of sweat regulation and that sweat rate is a function of delta Tre and healthy skin surface area.

Adult↗

Heat tolerance in patients with extensive healed burns.

Some thermoregulatory parameters of 10 subjects with healed burns were studied. The subjects, 4 of whom had healed burns of over 40 percent (group A) and 6 with burns smaller than 30 percent (group B) were assigned in a climatic chamber to 3 hours bench stepping (30 cm height) under 40 degrees C and 50 percent relative humidity. Rectal temperature, weighted skin temperature, heat storage, and heart rate were all found to be significantly higher in group A than in group B or group C (control group of normal subjects). No significant difference was observed between groups B and C. A highly significant linear correlation (r = 0.89) was found between the sweat rate and percentage of burned area. In addition, 3 subjects of group A terminated the study after less than 90 minutes. Two subjects in group B terminated the study after 120 and 135 minutes, while all subjects of group C finished the entire 3 hour work. The study indicates that subjects with burns of over 40 percent could be classified as heat intolerant due to a pronounced reduction in perspiration area.

Adult↗

Multiple linear spiradenomas.

A case of eccrine spiradenoma (ESA) is described in a 35-year-old man. During an 18-year period, the original number of tumors grew in size and fused into large groups. Surgical excision of all tumors was performed successfully. The unusual features of the case were a linear distribution and giant multifocal tumors. The histology of the tumors and their appearance at the beginning and 18 years later is described.

Adenoma, Sweat Gland↗

Impending Volkmann's contracture in a newborn.

A newborn presented with severe necrosis of the volar aspect of the forearm and impending Volkmann's contracture. This is the youngest such patient reported in the literature. We suspect prolonged intrauterine pressure from an amniotic band. Such bands are known to cause constricting rings, syndactyly, and congenital amputations. If our assumption is correct, this case is unique.

Amniotic Band Syndrome↗

Neovascularization of skin flaps: route and timing.

Axial flaps were elevated in a pig and rat model. Selective ligation of the vascular pedicles on days 1 to 7 following elevation of the flap demonstrated total necrosis of all flaps when the pedicles were ligated on the first, second, and third postoperative day in the pig, and up to 6 days inthe rat. Pedicle ligation beyond this time did not produce flap necorsis, indicating the establishment of adequate neovascularization for flap survival. Selective ligation of the artery or vein did not appear to be significant in the pig. In the rat flap, however, survival tended to occur sooner. Adequate neovascularization for flap survival was demonstrated as arising from both the wound edges and the bed, although vascular channels occurring from the bed appeared to be of greater importance. The relatively rapid rate of neovascularization that occurs for adequate flap survival suggests that if some way could be found to maintain flap viability during the first week, the feeding vessels need no longer remain patent and may be ligated or used for other purposes. This interesting observation has already allowed very early successful defatting of clinically transferred flaps.

Abdomen↗

The value of angiography prior to use of the latissimus dorsi myocutaneous flap.

In 5 patients studied, preoperative angiography showed the thoracodorsal artery to be patent in two--both of them then had successful transfers of latissimus dorsi myocutaneous flaps. Obliteration of this artery was apparent in 3 patients, precluding the operation. We suggest that selective preoperative angiography be performed in all patients in whom a latissimus dorsi myocutaneous flap transfer is being considered, as a patent thoracodorsal artery is essential to the success of this procedure.

Adult↗

Genetic studies in a family with inverted nipples (mammillae invertita).

A Jewish Sephardi family is reported in which 16 members are affected (15 females and 1 male) with inverted nipples. The one affected male and his brother also have gynecomastia. Under the assumption that this trait is transmitted as an autosomal dominant, linkage studies were done but were not revealing. Further family and investigative studies are needed in this disorder to understand better its pathogenesis and precise mode of genetic transmission.

Adult↗

Restoration of sensation to the hand by a free neurovascular flap from the first web space of the foot.

A neurovascular free flap from the first web space of the foot was used successfully in two patients for replacement of glabrous skin of the hand and fingers. The potential advantages of this flap are that (1) it may be used to replace large defects of glabrous skin, (2) it provides a rich vascular supply to the periphery of the hand, and (3) the sensation achieved approaches the normal for the intact glabrous skin of the hand.

Arteries↗