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Biomedical subjects

H Tschabitscher

Publications and source records attributed to H Tschabitscher.

At least 19 recordsLinked to original sources
PubMed1986

[Gamma globulin therapy in multiple sclerosis. Theoretical considerations and initial clinical experiences with 7S immunoglobulins in MS therapy].

The number of reports about successful therapeutical application of 7S-immunoglobulins in various auto-immune diseases such as ITP or autoimmune neutropenia or in myasthenia gravis has increased in recent years. Multiple Sclerosis (MS) is an inflammatory demyelinating disease, in which antibodies directed against various components of the myelin sheath play an important pathogenetic part. Increased antibody dependent cytotoxicity has been reported in MS, and myelinotoxic antibodies and a myelination inhibiting factor have been found in acute cases. Lately several authors have tested 7S-immunoglobulins in the treatment of MS. It is still too early for final judgement of the therapeutical efficacy, however, patients suffering from the progressive form of MS with exacerbations showed rather fast improvement of their latest neurological deficits, when treated shortly after a fresh bout. Mechanisms of action which should be taken into consideration include reduced antibody dependent cytotoxicity by surface receptor blocking reduction of the number of circulating myelinotoxic antibodies caused by a negative feed back mechanism, and removal of a neuroelectric inhibiting factor caused by antibodies.

Autoantibodies↗
PubMed1985

[Apolipoproteins A and B in cerebrovascular diseases].

The present study has proved unequivocally the value of determining apolipoproteins A and B and the APO-L A/B quotient for establishing the risk for cerebrovascular disease. The determination of apolipoproteins should be preferred to the determination of HDL, LDL and VLDL, which has been practised so far. While only 30% of a group of 88 patients suffering from cerebrovascular disease had serum cholesterol levels of more than 250 mg/dl and approx. 57% showed HDL values below 40 mg/dl, a reduced APO-L A/B relation (less than 1.75) was demonstrated in 74%. A reduced APO-L A/B quotient was also observed in more than 70% of 62 CVD patients whose cholesterol level was within the range of normal. Determination of apolipoproteins may, therefore, be regarded as further progress in risk factor diagnostic of arteriosclerotic disease.

Adult↗
PubMed1981

[Changes in serum lipoproteins in cerebrovascular disease (author's transl)].

The determination of serum cholesterol, triglycerides and lipoprotein cholesterol (VLDL, LDL and HDL) in 96 patients suffering from cerebral vascular disease showed that some parameters were significantly different from those recorded in a control population of corresponding age HDL values below 40 mg/dl were found in 50% of cases. Pathological LDH/HDL and VLDL/HDL ratios were found in 30.9% and 37.7%, respectively, of patients with cerebrovascular disease, whose serum cholesterol level was below 250 mg/dl and triglyceride level was 175 mg/dl. Only 56% of all patients had elevated serum cholesterol and/triglyceride and triglyceride alone does not detect the risk. The difference in the VLDL/HDL ratio in patients with cerebrovascular disease and that of the control population is highly significant. The HDL values and the VLDL/HDL ratio differ significantly, also. On average, the HDL levels in women are higher than those in men, but the decrease faster with increasing age. In both sexes a decrease in HDL level occurs between the age of 40 and 80. Low HDL levels and unfavourable LDL/HDL and VLDL/HDL quotients are important risk indicators for cerebrovascular disease.

Cerebrovascular Disorders↗
PubMed1981

Noninvasive rCBF determination by 133XE-inhalation with the gamma camera and functional imaging of wash-in and wash-out. A new combined approach for rCBE measurements in patients with cerebrovascular disease.

In 47 patients with cerebrovascular disease (CVD) a noninvasive determination of global and regional cerebral blood flow (CBF) was performed with the gamma camera. A new approach was developed for region definition and for evaluation of the "start-fit-time' as the point of minimal contamination of the recorded data by extracerebral scatter and recirculation using the region of interest (ROI)-technique in the camera field of view. In comparison with the results of probe measurement of end-tidal exhalation air no significant differences were seen and values obtained were well in the range reported by other authors. Initial slope (IS), gray matter flow (F1) and CBF-15 were used as quantitative parameters and were able to distinguish significantly (P less than 0.01) between normals, patients with mild CVD, and severe CVD. Intraexamination variation coefficient (VC) was 5%, interexamination VC was 8%. Functional, parametric images of wash-in for easier ROI-definition and judgement of isotope supply and of wash-out were generated by a computer analysis and were found to be sensitive indicators for arterial blood supply and wash-out values city. Thus it was possible to recalculate regional flow values in focal areas exactly corresponding to abnormalities seen on the functional images. So the regional information of functional images can be combined with the quantitative data in selectable areas. By tis noninvasive, easily performed method focal neurological deficits can be evaluated with high accuracy with conventional nucleus medicine equipment.

Cerebrovascular Circulation↗
PubMed1980

[Clinical course and CSF lactate in encephalomalacia (author's transl)].

LCS level of lactate and clinical status correlate well during the initial stage of encephalomalacia (2nd-4th day) and during a period of 12 to 14 days after infarction LCS level of lactate may, therefore, be regarded as important parameter for short-term prognosis of encephalomalcia. The use of a semiquantitative clinical score also permits predictions as to the extent of remission to be expected. The reliability of this model of prognosis is limited by the comparatively small number of patients so far examined, the assumption of a linear relation between clinical alterations and changes in LCS lactate, as well as by the difficulty of determining LCS lactate in most severe cases at the specific time requested by the examination programme.

Aged↗
PubMed1980

[Management and relapse prophylaxis of cerebral transitory ischemic attack (TIA) (author's transl)].

The paper gives a definition of the clinical concept of TIA, pointing out that the difference between TIA and ischemic brain infarction is not a qualitative but a quantitative one. Anatomy, physiology and metabolism of the brain will be discussed and clinical symptoms of TIA in the supply areas of the carotid and the vertebro-basilar arteries will be presented. Pathogenetic factors of TIA mentioned are: cardiac embolism, intravascular microembolism within the framework of cerebrovascular arteriosclerosis and alterations of blood composition, intracerebral steal mechanism, especially in cases of decreased systemic blood pressure and collateral circulation in stenotic or thrombotic vascular diseases. The paper stresses the importance of early diagnosis of TIA in view of the fact that approx. 30% of TIAs are not only followed by recurrent episodes but also develop into brain infarction. Clarification of the pathogenesis by appropriate examinations and causal therapy are therefore of particular importance. The significance of anticoagulant therapy, platelet aggregation inhibitors and cardiac therapy will be stressed and possible surgical management, especially the surgical bypass, will be presented. The curative and preventive effect of these forms of treatment will be evaluated.

Humans↗
PubMed1978

[Lactacidosis of the cerebrospinal fluid in apoplexy as indicator of prognosis (author's transl)].

Blood and CSF gases, as well as the level of lactate and pyruvate in blood and CSF were determined in 43 cases. of severe stroke with softening of the brain. It transpired that the CSF lactate level is the best prognostic indicator of survival. CSF values above 2,5 mMol/1 in apoplexy imply a very unfavourable prognosis. The CSF lactate level is also a very useful prognostic indicator in patients suffering from diabetes and/or uraemic metabolic disorders. As the determination of CSF lactate presents no tecnical difficulties and furnishes valuable prognostic information it would merit inclusion as a routine procedure in relevant cases.

Acidosis↗