Peutz-Jeghers syndrome and bilateral breast carcinoma.
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Biomedical subjects
Publications and source records attributed to H Trau.
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Computer analyses to identify correlations between thickness of primary superficial spreading malignant melanoma and eighteen variables previously reported to be related to prognosis were performed on a series of malignant melanomas. The variables that showed statistically significant (less than or equal to 0.05) direct relationships to thickness were level (Clark), elevation of lesion, age of patient, least and greatest diameters of lesion, history of bleeding, ulceration, clinical and histologic stage, anatomic location, pedunculation, and satellitosis. The variables that did not correlate with thickness were clinical diagnosis of regional lymphadenopathy, in-transit metastasis, duration of lesion, sex, history of a previous malignant melanoma, and history of a pre-existing lesion at the site of the development of melanoma. Multiple regression analysis of the factors that showed statistically significant correlation with thickness of the primary lesion revealed a subset of six dominant variables that were most predictive of thickness, namely, level, elevation, largest diameter of lesion, ulceration, histologic stage, and age of the patient.
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The wife of a 75-year-old man with zoster began to suffer from this disease some 24 days after is appeared in her husband. Although zoster is generally regarded to be an endogenously noncommunicable disease, the case reported herein suggests that the infection was exogenously communicated. The literature pointing up that zoster may possibly be acquired exogenously, particularly in immunosuppressed patients, is extensively reviewed.
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Clear cell acanthoma is usually a solitary benign epidermal tumor. Multiple lesions are rarely encountered, and only 11 such cases could be found in the literature. In all cases, the lesions were limited to the lower extremities. A few of the patients have had ichthyosis and/or varicose veins. We describe a 12th patient who, in addition to leg lesions, had lesions on the trunk and associated dry skin.
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